AiPD: Autoinhibited Protein Database

Gene name	Taf1b
Protein name	TATA box-binding protein-associated factor RNA polymerase I subunit B
Names	RNA polymerase I-specific TBP-associated factor 68 kDa, TAFI68, TATA box-binding protein-associated factor 1B, TBP-associated factor 1B, Transcription initiation factor SL1/TIF-IB subunit B
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:21340
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

20-93 (Predicted disordered autoinhibitory region) PR

20-93 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P97358-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs49293875	2	D>N	No	EVA
rs3411306051	72	W>*	No	EVA
rs3389230764	73	D>H	No	EVA
rs3389232551	78	E>V	No	EVA
rs48896353	126	R>H	No	EVA
rs3389226164	138	S>N	No	EVA
rs3389235005	151	L>P	No	EVA
rs29126550	178	K>T	No	EVA
rs3389233678	179	G>*	No	EVA
rs256406507	199	R>Q	No	EVA
rs3389237557	244	I>M	No	EVA
rs3403036601	245	N>K	No	EVA
rs3389195507	249	L>H	No	EVA
rs3389234994	249	L>I	No	EVA
rs3389195507	249	L>P	No	EVA
rs3389244426	262	G>D	No	EVA
rs3389202996	314	N>I	No	EVA
rs3389226272	347	K>E	No	EVA
rs3389206981	354	V>A	No	EVA
rs3389203047	369	L>W	No	EVA
rs3413025476	381	L>P	No	EVA
rs3389232330	387	E>K	No	EVA
rs219940828	390	R>K	No	EVA
rs3389248307	413	R>G	No	EVA
rs3389166778	414	R>Q	No	EVA
rs3389206948	425	W>R	No	EVA
rs3389228045	475	F>I	No	EVA
rs3389220587	517	F>L	No	EVA
rs3389233636	524	H>Q	No	EVA

Type	Name	Position	InterPro Accession
domain	Transcription initiation factor Rrn7, Zinc-finger	9 - 37	IPR021752

		Description
EC Number
Subcellular Localization	Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
RNA polymerase I core factor complex	A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p.
RNA polymerase I transcription regulator complex	A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase I.
RNA polymerase transcription factor SL1 complex	A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48.

Name	Definition
metal ion binding	Binding to a metal ion.
RNA polymerase I core promoter sequence-specific DNA binding	Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE.

Name	Definition
nucleolar large rRNA transcription by RNA polymerase I	The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I.
RNA polymerase I preinitiation complex assembly	The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase I promoter.
transcription by RNA polymerase I	The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P40992	RRN7	RNA polymerase I-specific transcription initiation factor RRN7	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q1JQD6	TAF1B	TATA box-binding protein-associated factor RNA polymerase I subunit B	Bos taurus (Bovine)	PR
Q9VH20	TAF1B	TATA box-binding protein-associated factor RNA polymerase I subunit B	Drosophila melanogaster (Fruit fly)	PR
D3ZYB7	Taf1b	TATA box-binding protein-associated factor RNA polymerase I subunit B	Rattus norvegicus (Rat)	PR
O01914	F23H11.2	TATA box-binding protein-associated factor RNA polymerase I subunit B	Caenorhabditis elegans	PR
Q5XVF0	MEE12	TATA box-binding protein-associated factor RNA polymerase I subunit B	Arabidopsis thaliana (Mouse-ear cress)	PR
F1R3W0	taf1b	TATA box-binding protein-associated factor RNA polymerase I subunit B	Danio rerio (Zebrafish) (Brachydanio rerio)	PR