O01914

PR
Gene name
F23H11.2
Protein name
TATA box-binding protein-associated factor RNA polymerase I subunit B
Names
TATA box-binding protein-associated factor 1B, TBP-associated factor 1B
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_F23H11.2
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

16-121 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O01914

Entry ID Method Resolution Chain Position Source
AF-O01914-F1 Predicted AlphaFoldDB

No variants for O01914

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O01914

No associated diseases with O01914

No regional properties for O01914

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O01914

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
RNA polymerase I core factor complex A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p.
RNA polymerase transcription factor SL1 complex A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
RNA polymerase I core promoter sequence-specific DNA binding Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE.

2 GO annotations of biological process

Name Definition
nucleolar large rRNA transcription by RNA polymerase I The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I.
RNA polymerase I preinitiation complex assembly The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase I promoter.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P40992 RRN7 RNA polymerase I-specific transcription initiation factor RRN7 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q1JQD6 TAF1B TATA box-binding protein-associated factor RNA polymerase I subunit B Bos taurus (Bovine) PR
Q9VH20 TAF1B TATA box-binding protein-associated factor RNA polymerase I subunit B Drosophila melanogaster (Fruit fly) PR
P97358 Taf1b TATA box-binding protein-associated factor RNA polymerase I subunit B Mus musculus (Mouse) PR
D3ZYB7 Taf1b TATA box-binding protein-associated factor RNA polymerase I subunit B Rattus norvegicus (Rat) PR
Q5XVF0 MEE12 TATA box-binding protein-associated factor RNA polymerase I subunit B Arabidopsis thaliana (Mouse-ear cress) PR
F1R3W0 taf1b TATA box-binding protein-associated factor RNA polymerase I subunit B Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MHSAKNEKCN ACGGYRFSVN DGFKYCDRCG ALFENFEELE EEEGGLQQTV GQGKVKVRKN
70 80 90 100 110 120
DDQKRVRNNA APVNLPKAQV MREALEKRSD FLQQQAIKGE ELELPHDATP DYLYRLALRL
130 140 150 160 170 180
FSFTQILAKS GHILVHELNF ESRVQENILA TFQKYLAHCQ VAFCHSEQCG NDEHLRFVAV
190 200 210 220 230 240
MENLRYEQEE REEKQRKRMA KRGKGVNALS KSAAAWTLLT QGNITEHLDI ASDEDGDQDA
250 260 270 280 290 300
QGGQQLDDLT LETTQNPDES IRVNDTTMGF VRKVTTALSK EALRRASQLI LNLEMLVAIL
310 320 330 340 350 360
HSALMSSGYQ TILTSDVVRW IREDRFRISR RSIRLIRQSQ PERMKQGEVV KPTIVDYAEP
370 380 390 400 410 420
FLRFPLYEIM RTCTIFHQSL KLASSMAPQS FESMSARLVD NLNLPSDILS RMLILESIIP
430 440 450 460 470 480
CDVSPQLLKQ VDVDMGYNCG QLAAMSPNVY YSGFLTSFGR KERGTQDADF CDEVLLSPDA
490 500 510 520 530 540
KLIAYLLLTL RLTFQLDNAQ CALQDDQYFD VDSWIHQLEM RIKCWQGHNM SLVMRSSSHV
550 560 570 580 590 600
PEMVVDPPFG TNYLFHQEKG APQVSCRRRQ AGFQKCIPTE MSFNSTSTLP TVFDVRHMGL
610 620 630 640 650 660
LTERCQMEAL ISPVKFQRTV LGNEIERDPL TFENVDRQSK NTFFKHFSAF KTTESCDTFE
670 680 690 700 710 720
EYFPCAKNYL LFKRPDWIQN CTARQTHFNP VTGPIRFYLS NQSCDDLLGT AATSFSRRFQ
730 740 750 760 770 780
FLLDALSLII GEDKKAVYAA FVMLEMHLTS SERIQSIRDD LLTSSPITLK CQKFRNSTHH
790 800 810 820 830 840
IPRKYGVISE VPIDRIENLR YFRLSRQFFE HEEMPTTINM ELIDYRNQEI RDSVTETEVQ
850 860
RAQNRIMKLC YEFEQFFGIL AVKFW