AiPD: Autoinhibited Protein Database

Gene name	RRN7 (YJL025W, J1273)
Protein name	RNA polymerase I-specific transcription initiation factor RRN7
Names
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YJL025W
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

18-121 (Predicted disordered autoinhibitory region) PR

18-121 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
5N5Y	EM	770 A	Q	1-514	PDB
5N5Z	EM	770 A	Q	1-514	PDB
5N60	EM	770 A	Q	1-514	PDB
5N61	EM	340 A	Q	1-514	PDB
5O7X	X-ray	320 A	B/E/H/K/N/Q	1-514	PDB
5OA1	EM	440 A	U	1-514	PDB
5W5Y	EM	380 A	P	1-514	PDB
5W64	EM	420 A	P	1-514	PDB
5W65	EM	430 A	P	1-514	PDB
5W66	EM	390 A	P	1-514	PDB
6RQH	EM	370 A	Q	1-514	PDB
6RQL	EM	290 A	Q	1-514	PDB
6RRD	EM	310 A	Q	1-514	PDB
6RUI	EM	270 A	Q	1-514	PDB
6RUO	EM	350 A	Q	1-514	PDB
6RWE	EM	300 A	Q	1-514	PDB
6TPS	EM	354 A	Q	1-514	PDB
AF-P40992-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s10-394109	50	G>S	No	SGRP
s10-394179	73	S>N	No	SGRP
s10-394212	84	Q>R	No	SGRP
s10-394255	98	H>Q	No	SGRP
s10-394319	120	I>V	No	SGRP
s10-394403	148	P>T	No	SGRP
s10-394566	202	S>L	No	SGRP
s10-394805	282	R>W	No	SGRP
s10-394925	322	R>G	No	SGRP
s10-395087	376	E>Q	No	SGRP
s10-395130	390	T>I	No	SGRP
s10-395139	393	L>S	No	SGRP
s10-395154	398	G>D	No	SGRP
s10-395167	402	M>I	No	SGRP
s10-395165	402	M>V	No	SGRP
s10-395204	415	K>E	No	SGRP
s10-395220	420	D>G	No	SGRP
s10-395254	431	D>E	No	SGRP
s10-395312	451	P>T	No	SGRP
s10-395322	454	E>A	No	SGRP
s10-395321	454	E>K	No	SGRP
s10-395324	455	S>R	No	SGRP
s10-395325	455	S>T	No	SGRP
s10-395390	477	G>S	No	SGRP

Type	Name	Position	InterPro Accession
domain	Transcription initiation factor Rrn7, Zinc-finger	5 - 37	IPR021752

		Description
EC Number
Subcellular Localization	Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RNA polymerase I core factor complex	A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p.
RNA polymerase transcription factor SL1 complex	A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48.

Name	Definition
metal ion binding	Binding to a metal ion.
RNA polymerase I core promoter sequence-specific DNA binding	Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE.
TBP-class protein binding	Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).

Name	Definition
nucleolar large rRNA transcription by RNA polymerase I	The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q1JQD6	TAF1B	TATA box-binding protein-associated factor RNA polymerase I subunit B	Bos taurus (Bovine)	PR
Q9VH20	TAF1B	TATA box-binding protein-associated factor RNA polymerase I subunit B	Drosophila melanogaster (Fruit fly)	PR
P97358	Taf1b	TATA box-binding protein-associated factor RNA polymerase I subunit B	Mus musculus (Mouse)	PR
D3ZYB7	Taf1b	TATA box-binding protein-associated factor RNA polymerase I subunit B	Rattus norvegicus (Rat)	PR
O01914	F23H11.2	TATA box-binding protein-associated factor RNA polymerase I subunit B	Caenorhabditis elegans	PR
Q5XVF0	MEE12	TATA box-binding protein-associated factor RNA polymerase I subunit B	Arabidopsis thaliana (Mouse-ear cress)	PR
F1R3W0	taf1b	TATA box-binding protein-associated factor RNA polymerase I subunit B	Danio rerio (Zebrafish) (Brachydanio rerio)	PR