AiPD: Autoinhibited Protein Database

Gene name	TAF1B
Protein name	TATA box-binding protein-associated factor RNA polymerase I subunit B
Names	RNA polymerase I-specific TBP-associated factor 63 kDa, TAFI63, TATA box-binding protein-associated factor 1B, TBP-associated factor 1B, Transcription initiation factor SL1/TIF-IB subunit B
Species	Bos taurus (Bovine)
KEGG Pathway	bta:511236
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

102-223 (Predicted disordered autoinhibitory region) PR

102-223 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q1JQD6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs464885490	9	F>V	No	EVA
rs456129357	13	C>F	No	EVA
rs437860293	24	T>A	No	EVA
rs467722105	26	E>G	No	EVA
rs467370031	133	T>R	No	EVA
rs798491190	134	V>I	No	EVA
rs472400265	135	L>*	No	EVA
rs441877098	136	E>D	No	EVA
rs474317481	166	S>C	No	EVA
rs462270169	178	I>S	No	EVA
rs440489996	179	I>T	No	EVA
rs438034692	197	V>G	No	EVA
rs455927150	202	R>P	No	EVA
rs434293504	203	K>E	No	EVA
rs466977491	210	M>I	No	EVA
rs445427090	231	T>S	No	EVA
rs436837558	248	H>Y	No	EVA
rs481618749	301	C>S	No	EVA
rs459398419	305	P>R	No	EVA
rs470575952	311	K>R	No	EVA
rs452041719	317	N>H	No	EVA
rs443499423	318	L>P	No	EVA
rs466063307	364	V>I	No	EVA
rs448907033	380	S>A	No	EVA
rs435644986	452	V>E	No	EVA
rs475158342	456	K>I	No	EVA
rs453385945	458	F>V	No	EVA
rs464584830	466	P>Q	No	EVA
rs437523669	469	E>K	No	EVA
rs470366513	501	Q>R	No	EVA
rs448747725	506	L>R	No	EVA
rs481618710	508	T>N	No	EVA
rs459336894	522	K>N	No	EVA
rs444092640	526	K>Q	No	EVA
rs461380299	527	H>N	No	EVA
rs443089801	531	Y>N	No	EVA
rs472982525	533	E>K	No	EVA
rs454346538	537	S>A	No	EVA
rs432522342	538	L>V	No	EVA
rs471824982	539	S>C	No	EVA
rs456048182	539	S>R	No	EVA
rs437687439	540	Y>S	No	EVA
rs467190462	545	N>S	No	EVA
rs448910366	546	L>I	No	EVA
rs724077562	553	I>V	No	EVA
rs466849055	556	S>C	No	EVA
rs466849055	556	S>F	No	EVA
rs445107839	557	F>Y	No	EVA
rs455284163	566	E>D	No	EVA
rs477967991	567	K>M	No	EVA
rs450197556	586	K>*	No	EVA
rs461341666	588	R>K	No	EVA
rs472591191	589	K>N	No	EVA
rs442765461	589	K>R	No	EVA
rs460819364	590	Y>*	No	EVA
rs471787881	591	Y>C	No	EVA
rs439107677	591	Y>G	No	EVA

Type	Name	Position	InterPro Accession
repeat	WD40 repeat	192 - 233	IPR001680-1
repeat	WD40 repeat	390 - 433	IPR001680-2
repeat	WD40 repeat	437 - 486	IPR001680-3

		Description
EC Number
Subcellular Localization	Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
RNA polymerase I core factor complex	A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p.
RNA polymerase transcription factor SL1 complex	A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48.

Name	Definition
metal ion binding	Binding to a metal ion.
RNA polymerase I core promoter sequence-specific DNA binding	Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE.

Name	Definition
nucleolar large rRNA transcription by RNA polymerase I	The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I.
RNA polymerase I preinitiation complex assembly	The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase I promoter.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P40992	RRN7	RNA polymerase I-specific transcription initiation factor RRN7	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q9VH20	TAF1B	TATA box-binding protein-associated factor RNA polymerase I subunit B	Drosophila melanogaster (Fruit fly)	PR
P97358	Taf1b	TATA box-binding protein-associated factor RNA polymerase I subunit B	Mus musculus (Mouse)	PR
D3ZYB7	Taf1b	TATA box-binding protein-associated factor RNA polymerase I subunit B	Rattus norvegicus (Rat)	PR
O01914	F23H11.2	TATA box-binding protein-associated factor RNA polymerase I subunit B	Caenorhabditis elegans	PR
Q5XVF0	MEE12	TATA box-binding protein-associated factor RNA polymerase I subunit B	Arabidopsis thaliana (Mouse-ear cress)	PR
F1R3W0	taf1b	TATA box-binding protein-associated factor RNA polymerase I subunit B	Danio rerio (Zebrafish) (Brachydanio rerio)	PR