Q9SU58

SS
Gene name
AHA4 (At3g47950, T17F15.180)
Protein name
ATPase 4, plasma membrane-type
Names
EC 7.1.2.1 , Proton pump 4
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G47950
EC number
7.1.2.1: Hydron translocation linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The plasma membrane H+-ATPase belongs to the superfamily of P-type ATPases. The H+-ATPase is responsible for the ATP-fuelled ejection of protons from the cell and is an important component in the generation of the trans-membrane H+ gradient in plant cells. The H+-ATPase AHA2 is controlled by an autoinhibitory C-terminal regulatory domain and activated by 14-3-3 proteins which bind to the part of the enzyme. In two regions of the C-terminus, alteration of the residues leads to increased pump activity. One region stretches from K863 to L885 and includes two residues (Q879 and R880) that are conserved between plant and fungal H+-ATPases. The other region, incorporating S904 to L919, is situated in an extension of the C-terminus unique to plant H+-ATPases.

Autoinhibitory domains (AIDs)

875-897 (Autoinhibitory domain I) SS

Target domain

317-545 (ATPase domain)

Relief mechanism

Partner binding

Assay

915-930 (Autoinhibitory domain II) SS

Target domain

317-545 (ATPase domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9SU58

Entry ID Method Resolution Chain Position Source
AF-Q9SU58-F1 Predicted AlphaFoldDB

78 variants for Q9SU58

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH06265032 5 V>M No 1000Genomes
tmp_3_17693034_A_T 7 D>V No 1000Genomes
tmp_3_17693045_G_A 11 V>I No 1000Genomes
ENSVATH00406810 25 V>L No 1000Genomes
tmp_3_17693167_T_C 27 I>T No 1000Genomes
tmp_3_17693176_T_C 30 V>A No 1000Genomes
ENSVATH12624764 43 T>S No 1000Genomes
tmp_3_17693217_C_G 44 Q>E No 1000Genomes
ENSVATH06265036 66 F>L No 1000Genomes
ENSVATH06265038 74 W>* No 1000Genomes
tmp_3_17693454_T_G 86 I>M No 1000Genomes
ENSVATH06265040 127 N>I No 1000Genomes
ENSVATH12624786 128 A>G No 1000Genomes
ENSVATH00406812 133 M>I No 1000Genomes
tmp_3_17693690_C_T 138 P>L No 1000Genomes
ENSVATH12624787 140 A>T No 1000Genomes
ENSVATH06265050 147 R>K No 1000Genomes
tmp_3_17693871_G_T 150 E>* No 1000Genomes
ENSVATH00406814 159 G>S No 1000Genomes
tmp_3_17693917_A_T 165 K>M No 1000Genomes
ENSVATH02465856 171 P>S No 1000Genomes
tmp_3_17693955_G_A 178 E>K No 1000Genomes
ENSVATH06265053 188 A>V No 1000Genomes
ENSVATH12624815 204 V>A No 1000Genomes
tmp_3_17694287_A_G 241 I>V No 1000Genomes
tmp_3_17694545_C_T 279 R>C No 1000Genomes
ENSVATH06265062 353 L>V No 1000Genomes
tmp_3_17694895_T_A 395 D>E No 1000Genomes
tmp_3_17694893_G_A 395 D>N No 1000Genomes
ENSVATH00406818 399 G>S No 1000Genomes
tmp_3_17695004_T_G 400 I>S No 1000Genomes
ENSVATH14397445 420 I>T No 1000Genomes
ENSVATH06265063 422 N>D No 1000Genomes
ENSVATH14397446 423 E>K No 1000Genomes
tmp_3_17695223_G_A 441 A>T No 1000Genomes
tmp_3_17695234_A_T 444 K>N No 1000Genomes
tmp_3_17695233_A_G 444 K>R No 1000Genomes
ENSVATH02465859 447 I>V No 1000Genomes
ENSVATH00406821 451 V>L No 1000Genomes
ENSVATH06265065 456 D>G No 1000Genomes
ENSVATH06265066 462 G>A No 1000Genomes
tmp_3_17695292_C_T 464 R>* No 1000Genomes
ENSVATH06265067 469 A>V No 1000Genomes
ENSVATH12624848 476 G>W No 1000Genomes
ENSVATH06265071 530 G>A No 1000Genomes
ENSVATH06265072 531 R>C No 1000Genomes
tmp_3_17695758_A_G 537 T>A No 1000Genomes
tmp_3_17695759_C_T 537 T>I No 1000Genomes
ENSVATH06265073 545 L>F No 1000Genomes
ENSVATH06265074 563 I>V No 1000Genomes
tmp_3_17695870_C_T 574 P>L No 1000Genomes
tmp_3_17695953_C_G 576 H>D No 1000Genomes
ENSVATH12624851 595 G>V No 1000Genomes
tmp_3_17696016_G_A 597 G>S No 1000Genomes
ENSVATH14397448 623 A>T No 1000Genomes
tmp_3_17696170_A_G 648 Q>R No 1000Genomes
ENSVATH06265076 650 M>I No 1000Genomes
ENSVATH02465862 661 T>I No 1000Genomes
tmp_3_17696482_T_G 689 I>M No 1000Genomes
tmp_3_17696638_C_T 705 P>S No 1000Genomes
tmp_3_17696669_C_T 715 S>F No 1000Genomes
tmp_3_17696757_C_G 744 F>L No 1000Genomes
ENSVATH12624885 747 R>G No 1000Genomes
tmp_3_17696884_G_A 751 V>I No 1000Genomes
tmp_3_17696920_C_G 763 R>G No 1000Genomes
tmp_3_17696971_C_G 780 L>V No 1000Genomes
ENSVATH02465863 783 V>A No 1000Genomes
ENSVATH06265090 787 R>Q No 1000Genomes
tmp_3_17697004_T_A 791 F>I No 1000Genomes
ENSVATH06265091 801 I>V No 1000Genomes
ENSVATH12624887 812 L>V No 1000Genomes
ENSVATH12624888 818 N>H No 1000Genomes
ENSVATH14397452 832 A>P No 1000Genomes
tmp_3_17697270_T_A 844 I>N No 1000Genomes
tmp_3_17697273_C_G 845 P>R No 1000Genomes
ENSVATH06265095 845 P>S No 1000Genomes
ENSVATH06265096 849 I>L No 1000Genomes
ENSVATH14397465 955 Q>K No 1000Genomes

No associated diseases with Q9SU58

8 regional properties for Q9SU58

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 564 - 791 IPR003439-1
domain ABC transporter-like, ATP-binding domain 1174 - 1407 IPR003439-2
domain AAA+ ATPase domain 594 - 768 IPR003593-1
domain AAA+ ATPase domain 1200 - 1390 IPR003593-2
domain ABC transporter type 1, transmembrane domain 299 - 530 IPR011527-1
domain ABC transporter type 1, transmembrane domain 853 - 1139 IPR011527-2
conserved_site ABC transporter-like, conserved site 692 - 706 IPR017871-1
conserved_site ABC transporter-like, conserved site 1310 - 1324 IPR017871-2

Functions

Description
EC Number 7.1.2.1 Hydron translocation linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction
metal ion binding Binding to a metal ion.
P-type proton-exporting transporter activity Enables the transfer of protons from one side of a membrane to the other according to the reaction

3 GO annotations of biological process

Name Definition
proton export across plasma membrane The directed movement of hydrogen ions (protons) from inside a cell, across the plasma membrane and into the extracellular region.
regulation of intracellular pH Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.
response to salt stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P83970 ha1 Plasma membrane ATPase Triticum aestivum (Wheat) SS
A7L9Z8 Atp2c2 Calcium-transporting ATPase type 2C member 2 Mus musculus (Mouse) PR
Q80XR2 Atp2c1 Calcium-transporting ATPase type 2C member 1 Mus musculus (Mouse) PR
Q7XPY2 Os04g0656100 Plasma membrane ATPase Oryza sativa subsp. japonica (Rice) SS
P20431 AHA3 ATPase 3, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
P20649 AHA1 ATPase 1, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q43128 AHA10 ATPase 10, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9LV11 AHA11 ATPase 11, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9LY32 AHA7 ATPase 7, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9M2A0 AHA8 ATPase 8, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9SH76 AHA6 ATPase 6, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9SJB3 AHA5 ATPase 5, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
P19456 AHA2 ATPase 2, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) EV
Q42556 AHA9 ATPase 9, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
P22180 LHA1 Plasma membrane ATPase 1 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) SS
10 20 30 40 50 60
MTTTVEDNRE VLEAVLKEAV DLENVPIEEV FENLRCSKEG LTTQAADERL ALFGHNKLEE
70 80 90 100 110 120
KKESKFLKFL GFMWNPLSWV MEAAAIMAIA LANGGGKPPD WQDFVGIITL LVINSTISFI
130 140 150 160 170 180
EENNAGNAAA ALMARLAPKA KVLRDGRWGE QDAAILVPGD IISIKLGDIV PADARLLEGD
190 200 210 220 230 240
PLKIDQSALT GESLPVTKSS GDGVYSGSTC KQGEIEAVVI ATGVHTFFGK AAHLVDTTNQ
250 260 270 280 290 300
IGHFQQVLTA IGNFCICSIA VGMLIEIVVM YPIQHRAYRP GIDNLLVLLI GGIPIAMPTV
310 320 330 340 350 360
LSVTMAIGSH RLSQQGAITK RMTAIEEMAG MDVLCSDKTG TLTLNKLTVD KNLIEVFMKG
370 380 390 400 410 420
VDADTVVLMA ARASRLENQD AIDAAIVGML ADPKDARAGI QEVHFLPFNP TDKRTALTYI
430 440 450 460 470 480
DNEGNTHRVS KGAPEQILNL AHNKSEIERR VHAVIDKFAE RGLRSLAVAY QDVPEGRKDS
490 500 510 520 530 540
AGGPWQFVGL MPLFDPPRHD SAETIRRALN LGVSVKMITG DQLAIGKETG RRLGMGTNMY
550 560 570 580 590 600
PSSALLGQNK DESIVALPVD ELIEKADGFA GVFPEHKYEI VKRLQARKHI CGMTGDGVND
610 620 630 640 650 660
APALKKADIG IAVADATDAA RSASDIVLTE PGLSVIISAV LTSRAIFQRM KNYTIYAVSI
670 680 690 700 710 720
TIRIVLGFML LALIWQFDFP PFMVLIIAIL NDGTIMTISK DRVKPSPLPD SWKLSEIFAT
730 740 750 760 770 780
GVVFGSYMAM MTVIFFWVSY KTDFFPRTFG VATLEKTAHD DFRKLASAIY LQVSIISQAL
790 800 810 820 830 840
IFVTRSRSWS FVERPGIFLM IAFILAQLVA TLIAVYANWS FAAIEGIGWG WAGVIWLYNI
850 860 870 880 890 900
IFYIPLDFIK FFIRYALSGR AWDLVIEQRV AFTRQKDFGK EQRELQWAHA QRTLHGLQAP
910 920 930 940 950
DTKMFTDRTH VSELNQMAEE AKRRAEIARL RELHTLKGHV ESVVRLKGLD IETIQQAYTV