Q9SH76

SS
Gene name
AHA6 (At2g07560, F9A16.7)
Protein name
ATPase 6, plasma membrane-type
Names
EC 7.1.2.1 , Proton pump 6
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G07560
EC number
7.1.2.1: Hydron translocation linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The plasma membrane H+-ATPase belongs to the superfamily of P-type ATPases. The H+-ATPase is responsible for the ATP-fuelled ejection of protons from the cell and is an important component in the generation of the trans-membrane H+ gradient in plant cells. The H+-ATPase AHA2 is controlled by an autoinhibitory C-terminal regulatory domain and activated by 14-3-3 proteins which bind to the part of the enzyme. In two regions of the C-terminus, alteration of the residues leads to increased pump activity. One region stretches from K863 to L885 and includes two residues (Q879 and R880) that are conserved between plant and fungal H+-ATPases. The other region, incorporating S904 to L919, is situated in an extension of the C-terminus unique to plant H+-ATPases.

Autoinhibitory domains (AIDs)

865-887 (Autoinhibitory domain I) SS

Target domain

312-540 (ATPase domain)

Relief mechanism

Partner binding

Assay

904-919 (Autoinhibitory domain II) SS

Target domain

312-540 (ATPase domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9SH76

Entry ID Method Resolution Chain Position Source
AF-Q9SH76-F1 Predicted AlphaFoldDB

97 variants for Q9SH76

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH12018508 12 K>N No 1000Genomes
tmp_2_3173909_A_G 15 V>A No 1000Genomes
ENSVATH05322619 23 D>N No 1000Genomes
ENSVATH05322617 32 S>F No 1000Genomes
ENSVATH01694243 33 R>Q No 1000Genomes
tmp_2_3173704_G_A 50 A>V No 1000Genomes
tmp_2_3173649_C_T 68 M>I No 1000Genomes
ENSVATH00215635 78 A>V No 1000Genomes
ENSVATH05322615 80 A>T No 1000Genomes
tmp_2_3173595_C_A 86 L>F No 1000Genomes
tmp_2_3173582_C_T 91 G>R No 1000Genomes
tmp_2_3173522_T_A 111 T>S No 1000Genomes
ENSVATH05322613 129 A>T No 1000Genomes
ENSVATH01694233 150 I>T No 1000Genomes
ENSVATH01694234 150 I>V No 1000Genomes
ENSVATH14128484 156 L>F No 1000Genomes
ENSVATH14128483 166 P>L No 1000Genomes
tmp_2_3173348_C_A 169 A>S No 1000Genomes
tmp_2_3173311_T_C 181 Q>R No 1000Genomes
tmp_2_3173270_G_C 195 Q>E No 1000Genomes
ENSVATH00215632 195 Q>P No 1000Genomes
ENSVATH05322610 196 G>E No 1000Genomes
tmp_2_3173242_G_A 204 T>I No 1000Genomes
ENSVATH05322609 212 A>G No 1000Genomes
tmp_2_3173131_T_A 241 K>M No 1000Genomes
tmp_2_3172997_A_G 256 I>T No 1000Genomes
ENSVATH01694219 267 P>L No 1000Genomes
tmp_2_3172955_T_C 270 H>R No 1000Genomes
tmp_2_3172949_T_A 272 K>M No 1000Genomes
tmp_2_3172950_T_G 272 K>Q No 1000Genomes
tmp_2_3172947_A_G 273 Y>H No 1000Genomes
tmp_2_3172749_G_A 339 L>F No 1000Genomes
ENSVATH14128479 343 T>I No 1000Genomes
ENSVATH01694206 353 S>P No 1000Genomes
tmp_2_3172563_C_A 371 V>L No 1000Genomes
tmp_2_3172530_C_T 382 V>I No 1000Genomes
tmp_2_3172497_C_T 393 A>T No 1000Genomes
tmp_2_3172494_C_G 394 G>R No 1000Genomes
ENSVATH12018263 396 T>N No 1000Genomes
tmp_2_3172485_C_T 397 E>K No 1000Genomes
ENSVATH05322593 398 V>M No 1000Genomes
tmp_2_3172471_C_G 401 L>F No 1000Genomes
tmp_2_3172418_C_T 419 G>E No 1000Genomes
tmp_2_3172411_C_G 421 W>C No 1000Genomes
tmp_2_3172400_C_T 425 S>N No 1000Genomes
tmp_2_3172388_G_A 429 P>L No 1000Genomes
tmp_2_3172389_G_A 429 P>S No 1000Genomes
tmp_2_3172364_T_G 437 D>A No 1000Genomes
ENSVATH05322590 438 L>H No 1000Genomes
ENSVATH05322588 440 G>E No 1000Genomes
ENSVATH12018259 441 E>K No 1000Genomes
tmp_2_3172332_C_T 448 E>K No 1000Genomes
ENSVATH05322587 451 D>E No 1000Genomes
ENSVATH12018258 465 R>C No 1000Genomes
ENSVATH12018257 469 P>L No 1000Genomes
tmp_2_3172250_C_T 475 S>N No 1000Genomes
ENSVATH01694198 476 A>P No 1000Genomes
ENSVATH01694198 476 A>T No 1000Genomes
ENSVATH01694197 476 A>V No 1000Genomes
tmp_2_3172245_C_T 477 G>R No 1000Genomes
tmp_2_3172241_G_A 478 T>I No 1000Genomes
ENSVATH01694196 479 P>Q No 1000Genomes
tmp_2_3172233_C_G 481 E>Q No 1000Genomes
tmp_2_3172227_C_T 483 V>I No 1000Genomes
ENSVATH12018256 488 L>H No 1000Genomes
ENSVATH05322583 497 A>S No 1000Genomes
tmp_2_3172064_G_A 537 S>F No 1000Genomes
tmp_2_3172062_A_T 538 S>T No 1000Genomes
ENSVATH12018124 542 E>K No 1000Genomes
ENSVATH05322581 546 D>E No 1000Genomes
ENSVATH14128478 549 G>R No 1000Genomes
tmp_2_3171885_C_T 573 E>K No 1000Genomes
ENSVATH05322574 581 R>K No 1000Genomes
tmp_2_3171859_C_A 581 R>S No 1000Genomes
tmp_2_3171786_C_A 606 A>S No 1000Genomes
tmp_2_3171780_C_T 608 D>N No 1000Genomes
tmp_2_3171756_T_C 616 S>G No 1000Genomes
tmp_2_3171704_G_A 633 A>V No 1000Genomes
tmp_2_3171702_C_T 634 V>M No 1000Genomes
tmp_2_3171642_T_A 654 I>F No 1000Genomes
tmp_2_3171624_G_T 660 L>I No 1000Genomes
tmp_2_3171603_G_C 667 L>V No 1000Genomes
ENSVATH05322569 728 V>L No 1000Genomes
tmp_2_3171408_G_T 732 L>I No 1000Genomes
tmp_2_3171255_G_C 752 D>E No 1000Genomes
ENSVATH07793908 752 D>N No 1000Genomes
tmp_2_3171203_G_A 770 L>F No 1000Genomes
ENSVATH05322565 784 R>C No 1000Genomes
ENSVATH01694168 787 L>F No 1000Genomes
ENSVATH01694168 787 L>V No 1000Genomes
tmp_2_3170934_T_G 830 I>L No 1000Genomes
tmp_2_3170885_G_A 846 T>I No 1000Genomes
ENSVATH12017825 860 T>A No 1000Genomes
ENSVATH01694154 860 T>I No 1000Genomes
tmp_2_3170678_A_T 887 L>H No 1000Genomes
ENSVATH12017641 898 A>T No 1000Genomes
tmp_2_3170423_C_T 941 D>N No 1000Genomes

No associated diseases with Q9SH76

13 regional properties for Q9SH76

Type Name Position InterPro Accession
domain Protein kinase domain 623 - 886 IPR000719
domain Ephrin receptor ligand binding domain 11 - 189 IPR001090
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 623 - 882 IPR001245
conserved_site Tyrosine-protein kinase, receptor class V, conserved site 165 - 185 IPR001426-1
conserved_site Tyrosine-protein kinase, receptor class V, conserved site 228 - 248 IPR001426-2
domain Sterile alpha motif domain 912 - 979 IPR001660
domain Fibronectin type III 311 - 424 IPR003961-1
domain Fibronectin type III 425 - 522 IPR003961-2
active_site Tyrosine-protein kinase, active site 744 - 756 IPR008266
binding_site Protein kinase, ATP binding site 629 - 655 IPR017441
domain Tyrosine-protein kinase, catalytic domain 623 - 882 IPR020635
domain Ephrin receptor, transmembrane domain 535 - 619 IPR027936
domain Ephrin type-B receptor 3, ligand binding domain 11 - 183 IPR034245

Functions

Description
EC Number 7.1.2.1 Hydron translocation linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction
metal ion binding Binding to a metal ion.
P-type proton-exporting transporter activity Enables the transfer of protons from one side of a membrane to the other according to the reaction

2 GO annotations of biological process

Name Definition
proton export across plasma membrane The directed movement of hydrogen ions (protons) from inside a cell, across the plasma membrane and into the extracellular region.
regulation of intracellular pH Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P83970 ha1 Plasma membrane ATPase Triticum aestivum (Wheat) SS
Q80XR2 Atp2c1 Calcium-transporting ATPase type 2C member 1 Mus musculus (Mouse) PR
A7L9Z8 Atp2c2 Calcium-transporting ATPase type 2C member 2 Mus musculus (Mouse) PR
Q7XPY2 Os04g0656100 Plasma membrane ATPase Oryza sativa subsp. japonica (Rice) SS
P20431 AHA3 ATPase 3, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
P20649 AHA1 ATPase 1, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q43128 AHA10 ATPase 10, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9LV11 AHA11 ATPase 11, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9LY32 AHA7 ATPase 7, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9M2A0 AHA8 ATPase 8, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9SJB3 AHA5 ATPase 5, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9SU58 AHA4 ATPase 4, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
P19456 AHA2 ATPase 2, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) EV
Q42556 AHA9 ATPase 9, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
P22180 LHA1 Plasma membrane ATPase 1 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) SS
10 20 30 40 50 60
MAADISWDEI KKENVDLEKI PVDEVFQQLK CSREGLSSEE GRNRLQIFGA NKLEEKVENK
70 80 90 100 110 120
FLKFLGFMWN PLSWVMEAAA IMAIVLANGG GRPPDWQDFV GITCLLIINS TISFIEENNA
130 140 150 160 170 180
GNAAAALMAN LAPKTKVLRD GRWGEQEAAI LVPGDLISIK LGDIVPADAR LLEGDPLKID
190 200 210 220 230 240
QSALTGESLP ATKHQGDEVF SGSTCKQGEI EAVVIATGVH TFFGKAAHLV DSTNNVGHFQ
250 260 270 280 290 300
KVLTAIGNFC ICSIGIGMLI EIIIMYPIQH RKYRDGIDNL LVLLIGGIPI AMPTVLSVTM
310 320 330 340 350 360
AIGSHRLSQQ GAITKRMTAI EEMAGMDVLC SDKTGTLTLN KLTVDKNLIE VFSKDVDKDY
370 380 390 400 410 420
VILLSARASR VENQDAIDTS IVNMLGDPKE ARAGITEVHF LPFNPVEKRT AITYIDTNGE
430 440 450 460 470 480
WHRCSKGAPE QIIELCDLKG ETKRRAHEII DKFAERGLRS LGVARQRVPE KDKESAGTPW
490 500 510 520 530 540
EFVGLLPLFD PPRHDSAETI RRALDLGVNV KMITGDQLAI GKETGRRLGM GTNMYPSSSL
550 560 570 580 590 600
LENKDDTTGG VPVDELIEKA DGFAGVFPEH KYEIVRKLQE RKHIVGMTGD GVNDAPALKK
610 620 630 640 650 660
ADIGIAVDDA TDAARSASDI VLTEPGLSVI VSAVLTSRAI FQRMKNYTIY AVSITIRIVL
670 680 690 700 710 720
GFMLVALIWE FDFSPFMVLI IAILNDGTIM TISKDRVKPS PIPDSWKLKE IFATGVVLGT
730 740 750 760 770 780
YMALVTVVFF WLAHDTTFFS DKFGVRSLQG KDEELIAVLY LQVSIISQAL IFVTRSRSWS
790 800 810 820 830 840
FVERPGLLLL IAFFVAQLIA TLIATYAHWE FARIKGCGWG WCGVIWIYSI VTYIPLDILK
850 860 870 880 890 900
FITRYTLSGK AWNNMIENRT AFTTKKDYGR GEREAQWALA QRTLHGLKPP ESMFEDTATY
910 920 930 940
TELSEIAEQA KKRAEVARLR EVHTLKGHVE SVVKLKGLDI DNLNQHYTV