Q42556

SS
Gene name
AHA9 (At1g80660, F23A5.1, T21F11.1)
Protein name
ATPase 9, plasma membrane-type
Names
EC 7.1.2.1 , Proton pump 9
Species
Rattus norvegicus (Rat)
KEGG Pathway
ath:AT1G80660
EC number
3.1.4.11: Phosphoric diester hydrolases
Protein Class

Descriptions

PLCB1 catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Autoinhibitory region is a portion of the linker that separates the conserved X and Y boxes comprising the catalytic TIM barrel, at residues 468-539, and occludes the active site of PLCB1. The active site of a PLC isozyme toward phospholipid membranes should force the negatively charged X/Y linker away from the active site, therein relieving autoinhibition of the enzyme.

Autoinhibitory domains (AIDs)

868-890 (Autoinhibitory domain I) SS

Target domain

314-542 (ATPase domain)

Relief mechanism

Partner binding

Assay

909-924 (Autoinhibitory domain II) SS

Target domain

314-542 (ATPase domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q42556

Entry ID Method Resolution Chain Position Source
AF-Q42556-F1 Predicted AlphaFoldDB

39 variants for Q42556

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_30319582_C_T 70 M>I No 1000Genomes
ENSVATH14497034 93 G>E No 1000Genomes
tmp_1_30319334_C_T 131 A>T No 1000Genomes
tmp_1_30319229_C_A 143 G>C No 1000Genomes
tmp_1_30319153_G_A 168 P>L No 1000Genomes
tmp_1_30319064_C_T 198 G>S No 1000Genomes
ENSVATH05180307 248 I>M No 1000Genomes
tmp_1_30318860_C_T 266 V>M No 1000Genomes
tmp_1_30318800_G_T 286 L>I No 1000Genomes
ENSVATH05180306 287 I>L No 1000Genomes
ENSVATH05180305 312 Q>K No 1000Genomes
tmp_1_30318631_T_C 342 N>S No 1000Genomes
ENSVATH05180303 367 A>V No 1000Genomes
tmp_1_30318434_C_G 408 V>L No 1000Genomes
tmp_1_30318078_C_A 470 V>F No 1000Genomes
tmp_1_30318066_C_T 474 D>N No 1000Genomes
ENSVATH13845881 475 K>T No 1000Genomes
tmp_1_30317991_C_T 499 A>T No 1000Genomes
tmp_1_30317853_G_A 545 Q>* No 1000Genomes
ENSVATH14497031 550 S>Y No 1000Genomes
ENSVATH13845878 568 G>S No 1000Genomes
ENSVATH05180295 614 T>N No 1000Genomes
ENSVATH05180295 614 T>S No 1000Genomes
tmp_1_30317434_T_C 659 I>V No 1000Genomes
tmp_1_30317390_C_G 673 K>N No 1000Genomes
tmp_1_30317200_C_G 737 E>Q No 1000Genomes
tmp_1_30317072_T_G 754 N>H No 1000Genomes
ENSVATH13845875 762 V>I No 1000Genomes
ENSVATH01563363 770 S>N No 1000Genomes
ENSVATH05180293 798 M>I No 1000Genomes
tmp_1_30316822_C_T 812 W>* No 1000Genomes
tmp_1_30316803_C_A 819 G>C No 1000Genomes
tmp_1_30316529_G_T 883 A>E No 1000Genomes
tmp_1_30316502_G_A 892 P>L No 1000Genomes
tmp_1_30316490_G_T 896 S>* No 1000Genomes
tmp_1_30316478_T_G 900 N>T No 1000Genomes
tmp_1_30316265_G_C 943 L>V No 1000Genomes
tmp_1_30316252_G_T 947 A>D No 1000Genomes
tmp_1_30316246_T_C 949 Q>R No 1000Genomes

No associated diseases with Q42556

3 regional properties for Q42556

Type Name Position InterPro Accession
domain Basic-leucine zipper domain 71 - 135 IPR004827
domain Vertebrate interleukin-3 regulated transcription factor 130 - 461 IPR010533
domain Nuclear factor interleukin-3-regulated protein-like, bZIP domain 72 - 131 IPR047106

Functions

Description
EC Number 3.1.4.11 Phosphoric diester hydrolases
Subcellular Localization
  • Nucleus membrane
  • Cytoplasm
  • Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
plant-type vacuole A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction
metal ion binding Binding to a metal ion.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
P-type proton-exporting transporter activity Enables the transfer of protons from one side of a membrane to the other according to the reaction

2 GO annotations of biological process

Name Definition
proton export across plasma membrane The directed movement of hydrogen ions (protons) from inside a cell, across the plasma membrane and into the extracellular region.
regulation of intracellular pH Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P83970 ha1 Plasma membrane ATPase Triticum aestivum (Wheat) SS
Q7XPY2 Os04g0656100 Plasma membrane ATPase Oryza sativa subsp. japonica (Rice) SS
P19456 AHA2 ATPase 2, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) EV
P20431 AHA3 ATPase 3, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
P20649 AHA1 ATPase 1, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q43128 AHA10 ATPase 10, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9LV11 AHA11 ATPase 11, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9LY32 AHA7 ATPase 7, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9M2A0 AHA8 ATPase 8, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9SH76 AHA6 ATPase 6, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9SJB3 AHA5 ATPase 5, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9SU58 AHA4 ATPase 4, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
P22180 LHA1 Plasma membrane ATPase 1 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) SS
10 20 30 40 50 60
MAGAQPGVHA LQLKPVCVSD SLKKGTKFVK WDDDSTIVTP IILRTDPQGF FFYWTDQNKE
70 80 90 100 110 120
TELLDLSLVK DARCGKHAKA PKDPKLRELL DVGNIGHLEQ RMITVVYGPD LVNISHLNLV
130 140 150 160 170 180
AFQEEVAKEW TNEVFSLATN LLAQNMSRDA FLEKAYTKLK LQVTPEGRIP LKNIYRLFSA
190 200 210 220 230 240
DRKRVETALE ACSLPSSRND SIPQEDFTPD VYRVFLNNLC PRPEIDNIFS EFGAKSKPYL
250 260 270 280 290 300
TVDQMMDFIN LKQRDPRLNE ILYPPLKQEQ VQVLIEKYEP NSSLAKKGQM SVDGFMRYLS
310 320 330 340 350 360
GEENGVVSPE KLDLNEDMSQ PLSHYFINSS HNTYLTAGQL AGNSSVEMYR QVLLSGCRCV
370 380 390 400 410 420
ELDCWKGRTA EEEPVITHGF TMTTEISFKE VIEAIAECAF KTSPFPILLS FENHVDSPKQ
430 440 450 460 470 480
QAKMAEYCRL IFGDALLMEP LEKYPLESGV PLPSPMDLMY KILVKNKKKS HKSSEGSGKK
490 500 510 520 530 540
KLSEQASNTY SDSSSVFEPS SPGAGEADTE SDDDDDDDDC KKSSMDEGTA GSEAMATEEM
550 560 570 580 590 600
SNLVNYIQPV KFESFETSKK RNKSFEMSSF VETKGLEQLT KSPVEFVEYN KMQLSRIYPK
610 620 630 640 650 660
GTRVDSSNYM PQLFWNAGCQ MVALNFQTVD LAMQINMGMY EYNGKSGYRL KPEFMRRPDK
670 680 690 700 710 720
HFDPFTEGIV DGIVANTLSV KIISGQFLSD KKVGTYVEVD MFGLPVDTRR KAFKTKTSQG
730 740 750 760 770 780
NAVNPVWEEE PIVFKKVVLP SLACLRIAAY EEGGKFIGHR ILPVQAIRPG YHYICLRNER
790 800 810 820 830 840
NQPLMLPAVF VYIEVKDYVP DTYADVIEAL SNPIRYVNLM EQRAKQLAAL TLEDEEEVKK
850 860 870 880 890 900
EADPGETSSE APSETRTTPA ENGVNHTATL APKPPSQAPH SQPAPGSVKA PAKTEDLIQS
910 920 930 940 950 960
VLTEVEAQTI EELKQQKSFV KLQKKHYKEM KDLVKRHHKK TTELIKEHTT KYNEIQNDYL
970 980 990 1000 1010 1020
RRRAALEKSA KKDSKKKSEP SSPDHGSSAI EQDLAALDAE MTQKLIDLKD KQQQQLLNLR
1030 1040 1050 1060 1070 1080
QEQYYSEKYQ KREHIKLLIQ KLTDVAEECQ NNQLKKLKEI CEKEKKELKK KMDKKRQEKI
1090 1100 1110 1120 1130 1140
TEAKSKDKSQ MEEEKTEMIR SYIQEVVQYI KRLEEAQSKR QEKLVEKHKE IRQQILDEKP
1150 1160 1170 1180 1190 1200
KLQMELEQEY QDKFKRLPLE ILEFVQEAMK GKVSEDSNHG SAPPSLASDP AKVNLKSPSS
1210
EEVQGENAGR EFDTPL