AiPD: Autoinhibited Protein Database

Q9NZI8

Gene name	IGF2BP1 (CRDBP, VICKZ1, ZBP1)
Protein name	Insulin-like growth factor 2 mRNA-binding protein 1
Names	IGF2 mRNA-binding protein 1, IMP-1, IMP1, Coding region determinant-binding protein, CRD-BP, IGF-II mRNA-binding protein 1, VICKZ family member 1, Zipcode-binding protein 1, ZBP-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10642
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

40-111 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

40-111 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q9NZI8

Entry ID	Method	Resolution	Chain	Position	Source
3KRM	X-ray	275 A	A/B/C	404-566	PDB
6QEY	X-ray	220 A	A	194-369	PDB
AF-Q9NZI8-F1	Predicted				AlphaFoldDB

308 variants for Q9NZI8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA400127809 rs1344084453	2	N>S		No	ClinGen TOPMed
TCGA novel	4	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1421934086 CA400127828	5	Y>H		No	ClinGen gnomAD
rs1360261891 CA400127843	7	G>R		No	ClinGen gnomAD
CA400127846 rs1267859451	7	G>V		No	ClinGen gnomAD
rs779595957 CA8636051	8	N>K		No	ClinGen ExAC gnomAD
rs143509742 CA8636052	10	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA8636053 rs768155406	10	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1230364951 CA400127874	11	E>D		No	ClinGen gnomAD
CA400127877 rs1368653096	12	S>G		No	ClinGen TOPMed
rs776186264 CA8636054	12	S>T		No	ClinGen ExAC gnomAD
CA400127901 rs1408130892	16	A>T		No	ClinGen TOPMed
rs1598115757 CA400127931	20	K>E		No	ClinGen Ensembl
rs1309201133 CA400127952	23	A>T		No	ClinGen TOPMed
CA8636057 rs772846567	23	A>V		No	ClinGen ExAC gnomAD
CA400127957 rs1432093569	24	E>K		No	ClinGen TOPMed
CA400127966 rs1485406225	25	H>Y		No	ClinGen gnomAD
CA8636059 rs201168699	26	K>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8636058 rs201168699	26	K>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs774351967 CA8636060	26	K>R		No	ClinGen ExAC gnomAD
CA400127985 rs1225106503	28	S>T		No	ClinGen gnomAD
CA400127995 rs746334059	29	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA8636063 rs746334059	29	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA8636065 rs764407782	34	L>F		No	ClinGen ExAC TOPMed gnomAD
CA8636066 rs754101030	35	V>L		No	ClinGen ExAC gnomAD
CA400128050 rs1205790831	37	S>F		No	ClinGen TOPMed
TCGA novel	38	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	40	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	41	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8636068 rs779218009	43	D>E		No	ClinGen ExAC TOPMed gnomAD
CA8636070 rs758957391	45	P>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	48	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747691671 CA8636072	52	K>N		No	ClinGen ExAC gnomAD
CA8636071 rs200362453	52	K>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs746176970 CA400128173	54	I>M		No	ClinGen gnomAD
CA400128187 rs1245156730	56	T>I		No	ClinGen gnomAD
CA291388405 rs987277426	57	F>L		No	ClinGen TOPMed gnomAD
rs1598117229 CA400128600	60	K>E		No	ClinGen Ensembl
rs778819788 CA8636101	63	L>V		No	ClinGen ExAC gnomAD
rs745689026 CA8636102	64	Q>K		No	ClinGen ExAC gnomAD
rs772084376 CA8636103	64	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA400128716 rs1448087640	66	K>R		No	ClinGen TOPMed gnomAD
rs760602261 CA8636105	68	L>I		No	ClinGen ExAC gnomAD
rs893542438 CA291390304	69	E>G		No	ClinGen TOPMed
CA400128788 rs1186859822	70	I>F		No	ClinGen gnomAD
CA400128835 rs1364192239	71	E>A		No	ClinGen TOPMed
TCGA novel	74	V>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	79	R>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1223519286 CA400130828	80	S>C		No	ClinGen gnomAD
CA400130843 rs1291250091	81	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs987788624 CA291412898	89	P>L		No	ClinGen Ensembl
rs771183397 CA8636165	92	L>V		No	ClinGen ExAC gnomAD
rs759839830 CA400130982	93	R>L		No	ClinGen ExAC TOPMed gnomAD
rs759839830 CA291412937	93	R>P		No	ClinGen ExAC TOPMed gnomAD
CA8636167 rs759839830	93	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1239541424 CA400130985	94	W>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs998753269 CA291413696	96	V>A		No	ClinGen Ensembl
rs762570324 CA8636194	99	S>R		No	ClinGen ExAC gnomAD
rs1195726880 CA400131152	104	Y>H		No	ClinGen gnomAD
TCGA novel	109	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400131392 rs1317534592	114	N>H		No	ClinGen TOPMed
CA400131399 rs1233137027	114	N>K		No	ClinGen TOPMed gnomAD
CA400131411 rs1424280858	116	E>A		No	ClinGen TOPMed
rs1161967930 CA400131406	116	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA8636221 rs757274629	119	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1193251518 CA400131447	122	V>L		No	ClinGen gnomAD
rs780442593 CA8636225	124	V>I		No	ClinGen ExAC gnomAD
rs755394340 CA8636227	127	S>A		No	ClinGen ExAC gnomAD
CA291419328 rs1021151923	128	N>K		No	ClinGen TOPMed gnomAD
rs138731585 CA8636228	128	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1257525409 CA400131493	129	R>Q		No	ClinGen TOPMed gnomAD
rs1449151062 CA400131492	129	R>W		No	ClinGen TOPMed
rs904086158 CA291419331	130	E>D		No	ClinGen TOPMed gnomAD
COSM170350 rs1567824517 CA400131623	145	E>D	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA400131630 rs1567824526	146	N>K		No	ClinGen Ensembl
CA400131628 rs1278971036	146	N>S		No	ClinGen gnomAD
rs768336961 CA8636257	147	H>Y		No	ClinGen ExAC gnomAD
rs1250904450 CA400131654	150	K>R		No	ClinGen gnomAD
CA400131706 rs1485652843	157	E>D		No	ClinGen TOPMed gnomAD
CA8636262 rs762860271	158	Q>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs766547480 CA8636263	159	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1429710029 CA400131715	159	I>V		No	ClinGen gnomAD
rs751732919 CA8636264	160	A>V		No	ClinGen ExAC gnomAD
CA400131729 rs1435140716	161	Q>R		No	ClinGen gnomAD
rs1373372719 CA400131743	163	P>H		No	ClinGen gnomAD
CA400131745 rs1414154484	164	E>K		No	ClinGen gnomAD
rs1225414237 CA400131760	165	N>K		No	ClinGen TOPMed
CA8636266 rs767875851	166	G>E		No	ClinGen ExAC gnomAD
CA400131768 rs1364176184 COSM2154294	167	R>C	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA8636267 COSM1254649 rs557111796	167	R>H	Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs756506419 CA8636268	168	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1024617698 COSM1285485 CA291423797	168	R>Q	Variant assessed as Somatic; 0.0 impact. autonomic_ganglia [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA400131777 rs1236728494	169	G>E		No	ClinGen gnomAD
CA400131782 rs1344356358	170	G>D		No	ClinGen TOPMed
rs754354262 CA8636270	170	G>S		No	ClinGen ExAC gnomAD
CA400131800 rs1347881834	173	S>A		No	ClinGen gnomAD
rs554770601 CA8636271	173	S>F		No	ClinGen ExAC gnomAD
CA400131804 rs779507141	174	R>G		No	ClinGen ExAC TOPMed gnomAD
COSM1563786 rs746549698 CA8636273	174	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA8636272 COSM3402976 rs779507141	174	R>W	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	175	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8636274 rs576996590	175	G>S		No	ClinGen 1000Genomes ExAC gnomAD
rs999692017 CA291423829	175	G>V		No	ClinGen TOPMed
CA8636275 rs368043361	178	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1454481322 CA400131827	178	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	182	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8636277 rs769621595	182	P>T		No	ClinGen ExAC gnomAD
rs546002680 CA8636278	184	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs373305132 CA8636279	185	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs373305132 CA8636280	185	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1346843176 CA400131881	187	A>G		No	ClinGen gnomAD
CA400131884 rs1428759513	188	P>S		No	ClinGen gnomAD
TCGA novel	196	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752960224 CA8636284 COSM980702	199	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1311744230 CA400131959	199	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA400132008 rs1286998809	207	V>M		No	ClinGen gnomAD
rs764495682 CA400132039	211	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1355919908 CA400132057	214	E>G		No	ClinGen gnomAD
CA291423911 rs987445536	214	E>Q		No	ClinGen TOPMed
rs1254463789 CA400132067 COSM1521807	216	A>T	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs754194926 CA8636287	219	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1259690630 CA400132090 COSM1384042	219	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA8636288 rs757720909	220	N>D		No	ClinGen ExAC gnomAD
CA400132097 rs1598153974	220	N>K		No	ClinGen Ensembl
CA400132104 rs542203174	221	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8636291 rs754486391	224	Q>E		No	ClinGen ExAC gnomAD
rs780628959 CA8636292	224	Q>L		No	ClinGen ExAC gnomAD
rs1398927329 CA400132134	226	Q>P		No	ClinGen gnomAD
CA291423959 rs761394589	228	K>R		No	ClinGen gnomAD
TCGA novel	230	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1423628890 CA400132212	235	E>G		No	ClinGen gnomAD
CA8636305 rs760920753	236	N>S		No	ClinGen ExAC gnomAD
CA8636308 rs762174997	237	A>E		No	ClinGen ExAC TOPMed gnomAD
CA400132225 rs762174997	237	A>G		No	ClinGen ExAC TOPMed gnomAD
COSM177227 rs375360274 CA8636307	237	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA400132233 rs1314044357	239	A>T		No	ClinGen gnomAD
CA8636310 rs750922996	240	A>G		No	ClinGen ExAC gnomAD
rs1290955703 CA400132294	247	H>Q		No	ClinGen gnomAD
CA400132306 rs1355016643	249	T>I		No	ClinGen gnomAD
rs758955317 CA400132308	250	P>A		No	ClinGen ExAC TOPMed gnomAD
CA291424951 rs372725899	250	P>H		No	ClinGen TOPMed
CA400132309 rs372725899	250	P>L		No	ClinGen TOPMed
rs758955317 CA8636311	250	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1435878193 CA400132317	251	E>D		No	ClinGen gnomAD
CA400132328 rs1567825477	253	C>Y		No	ClinGen Ensembl
rs752184655 CA8636313	255	S>F		No	ClinGen ExAC TOPMed gnomAD
COSM980707 rs777305494 CA8636315	256	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA400132358 rs1417327264	258	K>E		No	ClinGen gnomAD
CA8636316 CA291424973 rs749024088	259	M>I		No	ClinGen ExAC TOPMed
rs1422446418 CA400132374	260	I>F		No	ClinGen TOPMed
CA8636318 rs757116350 CA8636317	264	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1475745177 CA400132402	264	M>V		No	ClinGen gnomAD
CA8636319 rs61751193 RCV000893715	265	H>Q		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs771942123 CA8636320	268	A>S		No	ClinGen ExAC gnomAD
TCGA novel	272	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747081335 CA8636322	273	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs758305338 CA8636338	274	A>S		No	ClinGen ExAC gnomAD
CA400132489 rs1567826065	274	A>V		No	ClinGen Ensembl
CA400132497 rs377717972	275	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
COSM980708 CA8636340 rs747039976	276	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel	277	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA291425597 rs374870420	281	I>M		No	ClinGen Ensembl
rs531902165 CA8636343	283	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs1351795505 CA400132548	284	H>N		No	ClinGen TOPMed
CA8636345 rs148311931	287	F>S		No	ClinGen 1000Genomes ExAC gnomAD
CA400132581 rs1255053882	288	V>A		No	ClinGen gnomAD
CA400132584 rs1443058441	289	G>R		No	ClinGen TOPMed
CA400132590 rs1337576688	290	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA400132592 rs1332823704	290	R>H		No	ClinGen TOPMed
CA8636347 rs771403201	292	I>V		No	ClinGen ExAC gnomAD
CA291425647 rs867806927	296	G>R		No	ClinGen Ensembl
CA8636349 rs760149333	297	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1456195691 CA400132647	299	L>V		No	ClinGen gnomAD
TCGA novel	300	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1326197559 CA400132655	300	K>R		No	ClinGen gnomAD
rs753438639 CA8636351	301	K>R		No	ClinGen ExAC gnomAD
rs1470236785 CA400132685	304	Q>H		No	ClinGen TOPMed
rs1018284140 CA400132684	304	Q>L		No	ClinGen TOPMed
rs1018284140 CA291425677	304	Q>R		No	ClinGen TOPMed
CA291425694 rs868139251	309	K>N		No	ClinGen Ensembl
rs1185408371 CA400132715	309	K>Q		No	ClinGen TOPMed
rs982380285 CA291425690	309	K>R		No	ClinGen Ensembl
CA8636354 rs200635549	311	T>A		No	ClinGen ExAC gnomAD
rs1441769609 CA400132731	311	T>I		No	ClinGen TOPMed
TCGA novel	312	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA291425714 rs868021649	313	S>F		No	ClinGen Ensembl
COSM232524 CA8636356 rs368120375	314	S>L	Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA400132856 rs1598157270	328	T>S		No	ClinGen Ensembl
rs369838701 CA8636375	329	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	331	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1166523778 CA400132881	332	A>G		No	ClinGen gnomAD
rs1166523778 CA400132882	332	A>V		No	ClinGen gnomAD
rs781124783 CA8636377	333	I>M		No	ClinGen ExAC TOPMed gnomAD
CA8636376 rs557512533	333	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA8636378 COSM167085 rs752711229	334	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA291426421 rs113922999	337	C>R		No	ClinGen Ensembl
rs200690630 CA291426435	339	A>T		No	ClinGen Ensembl
rs749449720 CA8636381	346	K>R		No	ClinGen ExAC gnomAD
CA8636382 rs771227164	348	R>G		No	ClinGen ExAC TOPMed gnomAD
CA8636383 rs779104990	348	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA400132991 COSM189016 rs771227164	348	R>W	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1349043372 CA400133013	351	Y>C		No	ClinGen gnomAD
CA400133028 rs1237101284	353	N>I		No	ClinGen TOPMed
rs1598157362 CA400133043	355	V>G		No	ClinGen Ensembl
CA400133047 rs1598157368	356	A>P		No	ClinGen Ensembl
rs1334539377 CA400133051	356	A>V		No	ClinGen TOPMed
CA8636384 rs746264929	359	S>N		No	ClinGen ExAC gnomAD
CA400133146 rs1243869529	369	N>S		No	ClinGen Ensembl
rs1367344035 CA400133168	373	V>L		No	ClinGen gnomAD
TCGA novel CA400133189 rs1598158221	376	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
CA400133204 rs1452441310	378	A>V		No	ClinGen TOPMed
rs377397969 CA8636404	382	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA400133229 rs1318221519	382	A>V		No	ClinGen gnomAD
rs1266908925 CA400133234	383	V>A		No	ClinGen gnomAD
CA8636407 rs769324443	384	P>L		No	ClinGen ExAC TOPMed gnomAD
rs769324443 CA8636406	384	P>R		No	ClinGen ExAC TOPMed gnomAD
rs748846744 CA8636408	385	P>L		No	ClinGen ExAC TOPMed gnomAD
CA8636409 rs748846744	385	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA400133251 rs1347709176	387	P>A		No	ClinGen TOPMed
CA8636411 rs759245152	388	S>N		No	ClinGen ExAC gnomAD
rs767277963 CA8636412	389	S>G		No	ClinGen ExAC gnomAD
rs146124273 CA8636414	390	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1463263956 CA400133318	397	S>I		No	ClinGen TOPMed gnomAD
rs1463263956 CA400133317	397	S>T		No	ClinGen TOPMed gnomAD
CA400133337 rs1321755885	400	M>L		No	ClinGen gnomAD
CA291427207 rs879156967	400	M>T		No	ClinGen Ensembl
CA8636443 rs372405074	402	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA400133370 rs1374084344	403	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs778356223 CA8636445	404	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs367847325 CA8636448	407	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs574660242 CA8636447	407	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs753200252 CA291427495	409	Q>L		No	ClinGen Ensembl
rs746705512 CA400133417	410	V>L		No	ClinGen ExAC TOPMed gnomAD
CA8636449 rs746705512	410	V>M		No	ClinGen ExAC TOPMed gnomAD
CA8636452 rs761776197	414	A>T		No	ClinGen ExAC TOPMed gnomAD
CA400133454 rs1377751883	415	Q>H		No	ClinGen gnomAD
TCGA novel	417	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769647368 CA8636453	419	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA400133485 rs1339350732	420	I>M		No	ClinGen gnomAD
TCGA novel	422	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	426	Q>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767892641 CA8636459	433	R>Q		No	ClinGen ExAC gnomAD
rs759726551 CA8636458	433	R>W		No	ClinGen ExAC TOPMed gnomAD
rs753037418 CA8636460	436	S>I		No	ClinGen ExAC gnomAD
rs1447590050 CA400133615	440	K>Q		No	ClinGen gnomAD
COSM3387998 rs1567828109 CA400133660	445	E>K	pancreas [Cosmic]	No	ClinGen cosmic curated Ensembl
rs775868755 CA8636478	447	P>T		No	ClinGen ExAC gnomAD
TCGA novel	449	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	450	K>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1392636319 CA400133693	450	K>Q		No	ClinGen gnomAD
rs1384813692 CA400133697	450	K>R		No	ClinGen TOPMed gnomAD
CA400133696 rs1384813692	450	K>T		No	ClinGen TOPMed gnomAD
rs867424326 CA291427949 COSM980713	452	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA8636480 rs764506936	452	R>H		No	ClinGen ExAC gnomAD
CA8636481 rs754326846	453	M>I		No	ClinGen ExAC gnomAD
TCGA novel	453	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1411557711 CA400133712	453	M>V		No	ClinGen gnomAD
CA400133727 rs1328569902	455	I>F		No	ClinGen gnomAD
CA8636482 rs757806717	455	I>M		No	ClinGen ExAC gnomAD
CA400133732 rs1598159558	456	I>V		No	ClinGen Ensembl
rs765843488 CA8636483	457	T>A		No	ClinGen ExAC gnomAD
rs898125118 CA291427968	457	T>N		No	ClinGen TOPMed gnomAD
CA8636484 rs751061699	459	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	462	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755871368 CA400133860	473	K>I		No	ClinGen ExAC TOPMed gnomAD
rs752270787 CA8636506	473	K>Q		No	ClinGen ExAC gnomAD
CA8636507 rs755871368	473	K>T		No	ClinGen ExAC TOPMed gnomAD
CA291428401 rs267604937	476	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1296498386 CA400133896	478	N>S		No	ClinGen TOPMed gnomAD
CA291428405 rs985377212	482	P>T		No	ClinGen Ensembl
CA8636509 rs753711889	493	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA8636510 rs757206543	493	R>H		No	ClinGen ExAC TOPMed gnomAD
rs961565487 CA291428411	495	P>R		No	ClinGen gnomAD
CA8636512 rs781338712	501	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs745882726 CA8636513	509	T>K		No	ClinGen ExAC gnomAD
rs745882726 CA8636514	509	T>M		No	ClinGen ExAC gnomAD
rs1008328731	510	V>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758397448 CA8636532	515	N>Y		No	ClinGen ExAC gnomAD
COSM189017 CA400134166 rs1567828704	517	T>M	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA8636534 rs747113151	518	A>S		No	ClinGen ExAC gnomAD
rs986308034 CA291428677	522	V>I		No	ClinGen TOPMed
TCGA novel	526	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	527	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400134243 rs1158618978	529	P>L		No	ClinGen gnomAD
CA291428696 rs867369958	529	P>S		No	ClinGen Ensembl
rs973944510 CA291428700	533	D>N		No	ClinGen TOPMed gnomAD
CA8636540 rs763329263	536	I>V		No	ClinGen ExAC gnomAD
rs771495169 CA8636541	537	V>M		No	ClinGen ExAC gnomAD
TCGA novel	538	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400134316 rs1598160504	540	I>V		No	ClinGen Ensembl
rs1598160521 CA400134361	546	S>N		No	ClinGen Ensembl
TCGA novel	548	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8636570 rs751477755	551	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA400134424 rs1598162657	553	I>N		No	ClinGen Ensembl
CA8636571 rs754950045	554	R>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	557	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	558	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1401158246 CA400134466	560	V>I		No	ClinGen TOPMed
rs1215544623 CA400134481	562	Q>E		No	ClinGen Ensembl
CA400134484 rs1282004542	562	Q>R		No	ClinGen gnomAD
rs955603212 CA291430193	564	H>R		No	ClinGen TOPMed
CA400134534 rs1167427098	569	S>G		No	ClinGen TOPMed
rs901948834 CA291430197	571	Q>L		No	ClinGen Ensembl
TCGA novel	572	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1710440 CA8636578 rs749541733	575	R>Q	Variant assessed as Somatic; impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed
CA8636577 rs149888111	575	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1195152593 CA400134581	576	R>K		No	ClinGen gnomAD
rs1598162738 CA400134599	578	K>C		No	ClinGen Ensembl

No associated diseases with Q9NZI8

No regional properties for Q9NZI8

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9NZI8

Functions

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm Cytoplasm, perinuclear region Cytoplasm, P-body Cytoplasm, Stress granule Cell projection, lamellipodium Cell projection, dendrite Cell projection, dendritic spine Cell projection, growth cone Cell projection, filopodium Cell projection, axon	In the nucleus, located in discrete foci, coinciding with the sites of ACTB transcription (By similarity) In the cytoplasm, localizes in cytoplasmic mRNP granules Colocalizes with microtubules in growth cone filopodia and along neurites in neuronal cells (By similarity) Cytoplasmic colocalization with ACTB mRNA is partially lost at the cell periphery, suggesting release of the transcript In neuronal processes, exhibits fast retrograde and anterograde movements, when associated with ACTB mRNA; this motility is lost when the association is inhibited (By similarity) In hippocampal neurons, predominantly located within dendrites, particularly at dendritic branching points in young cells, compared to axons (By similarity) In axons, predominantly found in axonal branches and their growth cones (By similarity) In motile cells, such as migrating fibroblasts, localizes to leading edges where it colocalizes with microtubules and microfilaments and to retracting tails (By similarity) Dendritic levels are regulated by neuronal activity and glutaminergic signals: they are increased by KCl-induced depolarization, which induces rapid efflux from the cell body into dendrites, and decreased by the NMDA receptor agonist (By similarity) In motile cells, transported towards the leading edge into the cortical region of the lamellipodia where it is connected to microfilaments (By similarity) In response to cellular stress, such as oxidative stress or heat shock, recruited to stress granules, but not to processing bodies
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

15 GO annotations of cellular component

Name	Definition
anchoring junction	A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
CRD-mediated mRNA stability complex	A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic stress granule	A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendritic spine	A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
filopodium	Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
growth cone	The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
lamellipodium	A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
neuronal cell body	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
P-body	A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
ribonucleoprotein complex	A macromolecular complex that contains both RNA and protein molecules.

6 GO annotations of molecular function

Name	Definition
mRNA 3'-UTR binding	Binding to a 3' untranslated region of an mRNA molecule.
mRNA 5'-UTR binding	Binding to an mRNA molecule at its 5' untranslated region.
mRNA binding	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
N6-methyladenosine-containing RNA binding	Binding to an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs.
RNA binding	Binding to an RNA molecule or a portion thereof.
translation regulator activity	Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.

13 GO annotations of biological process

Name	Definition
CRD-mediated mRNA stabilization	An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD).
dendrite arborization	The process in which the anatomical structures of a dendritic tree are generated and organized into dendritic branches.
mRNA transport	The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.
negative regulation of translation	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
nervous system development	The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
neuronal stem cell population maintenance	Any process in by an organism or tissue maintains a population of neuronal stem cells.
pallium cell proliferation in forebrain	The multiplication or reproduction of pallium cells in the forebrain, resulting in the expansion of the cell population.
positive regulation of cytoplasmic translation	Any process that activates or increases the frequency, rate or extent of cytoplasmic translation.
regulation of cytokine production	Any process that modulates the frequency, rate, or extent of production of a cytokine.
regulation of gene expression	Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of mRNA stability involved in response to stress	Any process that modulates the propensity of mRNA molecules to degradation that is part of a change in state or activity of a cell as a result of an exogenous disturbance.
regulation of RNA metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.

11 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5ZLP8	IGF2BP3	Insulin-like growth factor 2 mRNA-binding protein 3	Gallus gallus (Chicken)	PR
O42254	IGF2BP1	Insulin-like growth factor 2 mRNA-binding protein 1	Gallus gallus (Chicken)	PR
O00425	IGF2BP3	Insulin-like growth factor 2 mRNA-binding protein 3	Homo sapiens (Human)	PR
Q9Y6M1	IGF2BP2	Insulin-like growth factor 2 mRNA-binding protein 2	Homo sapiens (Human)	PR
Q96I24	FUBP3	Far upstream element-binding protein 3	Homo sapiens (Human)	PR
Q15365	PCBP1	Poly(rC)-binding protein 1	Homo sapiens (Human)	PR
Q5SF07	Igf2bp2	Insulin-like growth factor 2 mRNA-binding protein 2	Mus musculus (Mouse)	PR
Q9CPN8	Igf2bp3	Insulin-like growth factor 2 mRNA-binding protein 3	Mus musculus (Mouse)	PR
O88477	Igf2bp1	Insulin-like growth factor 2 mRNA-binding protein 1	Mus musculus (Mouse)	PR
Q8CGX0	Igf2bp1	Insulin-like growth factor 2 mRNA-binding protein 1	Rattus norvegicus (Rat)	PR
Q08CK7	igf2bp1	Insulin-like growth factor 2 mRNA-binding protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MNKLYIGNLN	ESVTPADLEK	VFAEHKISYS	GQFLVKSGYA	FVDCPDEHWA	MKAIETFSGK
70	80	90	100	110	120
VELQGKRLEI	EHSVPKKQRS	RKIQIRNIPP	QLRWEVLDSL	LAQYGTVENC	EQVNTESETA
130	140	150	160	170	180
VVNVTYSNRE	QTRQAIMKLN	GHQLENHALK	VSYIPDEQIA	QGPENGRRGG	FGSRGQPRQG
190	200	210	220	230	240
SPVAAGAPAK	QQQVDIPLRL	LVPTQYVGAI	IGKEGATIRN	ITKQTQSKID	VHRKENAGAA
250	260	270	280	290	300
EKAISVHSTP	EGCSSACKMI	LEIMHKEAKD	TKTADEVPLK	ILAHNNFVGR	LIGKEGRNLK
310	320	330	340	350	360
KVEQDTETKI	TISSLQDLTL	YNPERTITVK	GAIENCCRAE	QEIMKKVREA	YENDVAAMSL
370	380	390	400	410	420
QSHLIPGLNL	AAVGLFPASS	SAVPPPPSSV	TGAAPYSSFM	QAPEQEMVQV	FIPAQAVGAI
430	440	450	460	470	480
IGKKGQHIKQ	LSRFASASIK	IAPPETPDSK	VRMVIITGPP	EAQFKAQGRI	YGKLKEENFF
490	500	510	520	530	540
GPKEEVKLET	HIRVPASAAG	RVIGKGGKTV	NELQNLTAAE	VVVPRDQTPD	ENDQVIVKII
550	560	570
GHFYASQMAQ	RKIRDILAQV	KQQHQKGQSN	QAQARRK