AiPD: Autoinhibited Protein Database

Gene name	Igf2bp3 (Vickz3)
Protein name	Insulin-like growth factor 2 mRNA-binding protein 3
Names	IGF2 mRNA-binding protein 3, IMP-3, mIMP-3, IGF-II mRNA-binding protein 3, VICKZ family member 3
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:140488
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

125-268 (Predicted disordered autoinhibitory region) PR

125-268 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
7VKL	X-ray	195 A	A	192-355	PDB
7VSJ	X-ray	238 A	A	1-161	PDB
7YEW	X-ray	250 A	A/C	1-161	PDB
7YEX	X-ray	200 A	A	1-160	PDB
7YEY	X-ray	185 A	A	192-355	PDB
AF-Q9CPN8-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388831696	95	E>*	No	EVA
rs3388823827	97	L>M	No	EVA
rs3388826236	116	D>V	No	EVA
rs3388830424	126	Y>F	No	EVA
rs3396786162	145	E>G	No	EVA
rs3388826536	181	R>G	No	EVA
rs3388823848	214	E>K	No	EVA
rs3388807939	224	Q>H	No	EVA
rs3388823299	253	T>S	No	EVA
rs3388796965	305	D>N	No	EVA
rs3388823868	314	P>Q	No	EVA
rs3388830371	330	K>NG*	No	EVA
rs3388831683	356	A>T	No	EVA
rs3396699980	362	A>S	No	EVA
rs3388808014	402	Q>E	No	EVA
rs3388831689	411	F>I	No	EVA
rs3388797022	453	M>L	No	EVA
rs3388829953	506	G>*	No	EVA
rs3388816971	511	N>K	No	EVA
rs3388823223	528	T>R	No	EVA
rs3388813019	539	I>M	No	EVA
rs3388826218	555	E>K	No	EVA
rs229160147	563	H>Q	No	EVA

Type	Name	Position	InterPro Accession
domain	TolB, N-terminal	23 - 121	IPR007195
repeat	WD40-like beta propeller	203 - 223	IPR011659-1
repeat	WD40-like beta propeller	237 - 272	IPR011659-2
repeat	WD40-like beta propeller	281 - 315	IPR011659-3
repeat	WD40-like beta propeller	369 - 396	IPR011659-4

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm Cytoplasm, P-body Cytoplasm, Stress granule	Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane The subcytoplasmic localization is cell specific and regulated by cell contact and growth Localized at the connecting piece and the tail of the spermatozoa In response to cellular stress, such as oxidative stress, recruited to stress granules
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic stress granule	A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
P-body	A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.

Name	Definition
mRNA 3'-UTR binding	Binding to a 3' untranslated region of an mRNA molecule.
mRNA 5'-UTR binding	Binding to an mRNA molecule at its 5' untranslated region.
mRNA binding	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
N6-methyladenosine-containing RNA binding	Binding to an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs.

Name	Definition
CRD-mediated mRNA stabilization	An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD).
mRNA transport	The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
nervous system development	The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
regulation of gene expression	Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of RNA metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
regulation of translation	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O42254	IGF2BP1	Insulin-like growth factor 2 mRNA-binding protein 1	Gallus gallus (Chicken)	PR
Q5ZLP8	IGF2BP3	Insulin-like growth factor 2 mRNA-binding protein 3	Gallus gallus (Chicken)	PR
Q9NZI8	IGF2BP1	Insulin-like growth factor 2 mRNA-binding protein 1	Homo sapiens (Human)	PR
Q9Y6M1	IGF2BP2	Insulin-like growth factor 2 mRNA-binding protein 2	Homo sapiens (Human)	PR
O00425	IGF2BP3	Insulin-like growth factor 2 mRNA-binding protein 3	Homo sapiens (Human)	PR
O88477	Igf2bp1	Insulin-like growth factor 2 mRNA-binding protein 1	Mus musculus (Mouse)	PR
Q5SF07	Igf2bp2	Insulin-like growth factor 2 mRNA-binding protein 2	Mus musculus (Mouse)	PR
P60335	Pcbp1	Poly(rC)-binding protein 1	Mus musculus (Mouse)	PR
Q8CGX0	Igf2bp1	Insulin-like growth factor 2 mRNA-binding protein 1	Rattus norvegicus (Rat)	PR
Q08CK7	igf2bp1	Insulin-like growth factor 2 mRNA-binding protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR