O88477

PR
Gene name
Igf2bp1 (Vickz1)
Protein name
Insulin-like growth factor 2 mRNA-binding protein 1
Names
B-cell maturation protein, IGF2 mRNA-binding protein 1, IMP-1, Coding region determinant-binding protein, CRD-BP, IGF-II mRNA-binding protein 1, VICKZ family member 1, Zipcode-binding protein 1, ZBP-1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:140486
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

127-221 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for O88477

Entry ID Method Resolution Chain Position Source
7WW3 X-ray 190 A A 400-577 PDB
AF-O88477-F1 Predicted AlphaFoldDB

33 variants for O88477

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389171367 15 P>L No EVA
rs3401992345 78 Q>K No EVA
rs3389171417 82 K>E No EVA
rs3389209826 84 Q>H No EVA
rs3389193812 106 T>R No EVA
rs3389158433 168 R>H No EVA
rs3389203819 188 P>L No EVA
rs3389182473 201 L>Q No EVA
rs3402954719 202 V>M No EVA
rs3402819201 206 Y>D No EVA
rs3411897568 213 K>E No EVA
rs3402533790 236 N>K No EVA
rs3389203797 243 A>V No EVA
rs3389130943 258 K>R No EVA
rs3389194901 292 I>M No EVA
rs3389205179 297 R>W No EVA
rs3389209848 304 Q>H No EVA
rs3389205138 334 E>V No EVA
rs3389209868 335 N>K No EVA
rs3389130997 335 N>S No EVA
rs3389171441 337 C>* No EVA
rs3389191976 337 C>G No EVA
rs3389193741 338 R>G No EVA
rs3389205130 340 E>G No EVA
rs3389164945 356 A>T No EVA
rs3389191977 375 L>P No EVA
rs3389193748 416 A>D No EVA
rs3401419762 443 P>S No EVA
rs3389182456 453 M>I No EVA
rs3412481360 470 I>V No EVA
rs3402717289 497 S>A No EVA
rs3402404240 498 A>E No EVA
rs3389198483 517 T>S No EVA

No associated diseases with O88477

3 regional properties for O88477

Type Name Position InterPro Accession
domain Immunoglobulin subtype 568 - 652 IPR003599
domain Immunoglobulin-like domain 562 - 650 IPR007110
domain Immunoglobulin I-set 563 - 651 IPR013098

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Cytoplasm, perinuclear region
  • Cytoplasm, P-body
  • Cytoplasm, Stress granule
  • Cell projection, lamellipodium
  • Cell projection, dendrite
  • Cell projection, dendritic spine
  • Cell projection, growth cone
  • Cell projection, filopodium
  • Cell projection, axon
  • In the nucleus, located in discrete foci, coinciding with the sites of ACTB transcription (By similarity)
  • In the cytoplasm, localizes in cytoplasmic mRNP granules
  • Colocalizes with microtubules in growth cone filopodia and along neurites in neuronal cells (By similarity)
  • Cytoplasmic colocalization with ACTB mRNA is partially lost at the cell periphery, suggesting release of the transcript (By similarity)
  • In hippocampal neurons, predominantly located within dendrites, particularly at dendritic branching points in young cells, compared to axons (By similarity)
  • In axons, predominantly found in axonal branches and their growth cones (By similarity)
  • In neuronal processes, exhibits fast retrograde and anterograde movements, when associated with ACTB mRNA; this motility is lost when the association is inhibited (By similarity)
  • Dendritic levels are regulated by neuronal activity and glutaminergic signals: they are increased by KCl-induced depolarization, which induces rapid efflux from the cell body into dendrites, and decreased by NMDA receptor agonists (By similarity)
  • In motile cells, such as migrating fibroblasts, localizes to leading edges where it colocalizes with microtubules and microfilaments and to retracting tails (By similarity)
  • In motile cells, transported towards the leading edge into the cortical region of the lamellipodia where it is connected to microfilaments (By similarity)
  • In response to cellular stress, such as oxidative stress or heat shock, recruited to stress granules, but not to processing bodies (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

17 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
CRD-mediated mRNA stability complex A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
dendritic spine A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
filopodium Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
growth cone The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
lamellipodium A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
P-body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.

5 GO annotations of molecular function

Name Definition
mRNA 3'-UTR binding Binding to a 3' untranslated region of an mRNA molecule.
mRNA 5'-UTR binding Binding to an mRNA molecule at its 5' untranslated region.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
N6-methyladenosine-containing RNA binding Binding to an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs.
translation regulator activity Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.

13 GO annotations of biological process

Name Definition
CRD-mediated mRNA stabilization An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD).
dendrite arborization The process in which the anatomical structures of a dendritic tree are generated and organized into dendritic branches.
mRNA transport The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.
negative regulation of translation Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
neuronal stem cell population maintenance Any process in by an organism or tissue maintains a population of neuronal stem cells.
pallium cell proliferation in forebrain The multiplication or reproduction of pallium cells in the forebrain, resulting in the expansion of the cell population.
positive regulation of cytoplasmic translation Any process that activates or increases the frequency, rate or extent of cytoplasmic translation.
regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of mRNA stability involved in response to stress Any process that modulates the propensity of mRNA molecules to degradation that is part of a change in state or activity of a cell as a result of an exogenous disturbance.
regulation of RNA metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
RNA localization A process in which RNA is transported to, or maintained in, a specific location.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5ZLP8 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 Gallus gallus (Chicken) PR
O42254 IGF2BP1 Insulin-like growth factor 2 mRNA-binding protein 1 Gallus gallus (Chicken) PR
O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 Homo sapiens (Human) PR
Q9Y6M1 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 Homo sapiens (Human) PR
Q9NZI8 IGF2BP1 Insulin-like growth factor 2 mRNA-binding protein 1 Homo sapiens (Human) PR
Q9CPN8 Igf2bp3 Insulin-like growth factor 2 mRNA-binding protein 3 Mus musculus (Mouse) PR
Q5SF07 Igf2bp2 Insulin-like growth factor 2 mRNA-binding protein 2 Mus musculus (Mouse) PR
P60335 Pcbp1 Poly(rC)-binding protein 1 Mus musculus (Mouse) PR
Q8CGX0 Igf2bp1 Insulin-like growth factor 2 mRNA-binding protein 1 Rattus norvegicus (Rat) PR
Q08CK7 igf2bp1 Insulin-like growth factor 2 mRNA-binding protein 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MNKLYIGNLN ESVTPADLEK VFAEHKISYS GQFLVKSGYA FVDCPDEHWA MKAIETFSGK
70 80 90 100 110 120
VELQGKRLEI EHSVPKKQRS RKIQIRNIPP QLRWEVLDSL LAQYGTVENC EQVNTESETA
130 140 150 160 170 180
VVNVTYSNRE QTRQAIMKLN GHQLENHALK VSYIPDEQIT QGPENGRRGG FGSRGQPRQG
190 200 210 220 230 240
SPVAAGAPAK QQPVDIPLRL LVPTQYVGAI IGKEGATIRN ITKQTQSKID VHRKENAGAA
250 260 270 280 290 300
EKAISVHSTP EGCSSACKMI LEIMHKEAKD TKTADEVPLK ILAHNNFVGR LIGKEGRNLK
310 320 330 340 350 360
KVEQDTETKI TISSLQDLTL YNPERTITVK GAIENCCRAE QEIMKKVREA YENDVAAMSL
370 380 390 400 410 420
QSHLIPGLNL AAVGLFPASS SAVPPPPSSV TGAAPYSSFM QAPEQEMVQV FIPAQAVGAI
430 440 450 460 470 480
IGKKGQHIKQ LSRFASASIK IAPPETPDSK VRMVVITGPP EAQFKAQGRI YGKLKEENFF
490 500 510 520 530 540
GPKEEVKLET HIRVPASAAG RVIGKGGKTV NELQNLTAAE VVVPRDQTPD ENDQVIVKII
550 560 570
GHFYASQMAQ RKIRDILAQV KQQHQKGQSN LAQARRK