AiPD: Autoinhibited Protein Database

Gene name	Pcbp1
Protein name	Poly(rC)-binding protein 1
Names	Alpha-CP1, Heterogeneous nuclear ribonucleoprotein E1, hnRNP E1
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:23983
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

144-299 (Predicted disordered autoinhibitory region) PR

144-299 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P60335-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388847937	30	G>V	No	EVA
rs3388831611	31	K>R	No	EVA
rs3388840770	33	G>W	No	EVA
rs36700459	272	A>S	No	EVA

Type	Name	Position	InterPro Accession
domain	Immunoglobulin subtype 2	41 - 107	IPR003598-1
domain	Immunoglobulin subtype 2	238 - 302	IPR003598-2
domain	Immunoglobulin subtype 2	328 - 391	IPR003598-3
domain	Immunoglobulin subtype 2	420 - 484	IPR003598-4
domain	Immunoglobulin subtype 2	510 - 583	IPR003598-5
domain	Immunoglobulin subtype	32 - 119	IPR003599-1
domain	Immunoglobulin subtype	129 - 215	IPR003599-2
domain	Immunoglobulin subtype	232 - 315	IPR003599-3
domain	Immunoglobulin subtype	322 - 402	IPR003599-4
domain	Immunoglobulin subtype	414 - 495	IPR003599-5
domain	Immunoglobulin subtype	504 - 594	IPR003599-6
domain	Fibronectin type III	597 - 697	IPR003961-1
domain	Fibronectin type III	700 - 799	IPR003961-2
domain	Fibronectin type III	801 - 899	IPR003961-3
domain	Fibronectin type III	900 - 995	IPR003961-4
domain	Immunoglobulin-like domain	32 - 117	IPR007110-1
domain	Immunoglobulin-like domain	122 - 206	IPR007110-2
domain	Immunoglobulin-like domain	225 - 311	IPR007110-3
domain	Immunoglobulin-like domain	316 - 400	IPR007110-4
domain	Immunoglobulin-like domain	406 - 493	IPR007110-5
domain	Immunoglobulin-like domain	497 - 586	IPR007110-6
domain	Immunoglobulin I-set	26 - 115	IPR013098-1
domain	Immunoglobulin I-set	318 - 401	IPR013098-2
domain	Immunoglobulin I-set	409 - 493	IPR013098-3
domain	Contactin-4, Ig6	496 - 597	IPR033007

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm	Loosely bound in the nucleus May shuttle between the nucleus and the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic ribonucleoprotein granule	A ribonucleoprotein granule located in the cytoplasm.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex	A macromolecular complex that contains both RNA and protein molecules.

Name	Definition
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
mRNA 3'-UTR binding	Binding to a 3' untranslated region of an mRNA molecule.
mRNA binding	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
RNA binding	Binding to an RNA molecule or a portion thereof.
sequence-specific single stranded DNA binding	Binding to single-stranded DNA of a specific nucleotide composition.
single-stranded DNA binding	Binding to single-stranded DNA.
translation activator activity	Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide.

Name	Definition
mRNA processing	Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of gene expression	Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of RNA metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
viral RNA genome replication	The replication of a viral RNA genome.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q15365	PCBP1	Poly(rC)-binding protein 1	Homo sapiens (Human)	PR
O88477	Igf2bp1	Insulin-like growth factor 2 mRNA-binding protein 1	Mus musculus (Mouse)	PR
Q9CPN8	Igf2bp3	Insulin-like growth factor 2 mRNA-binding protein 3	Mus musculus (Mouse)	PR
Q5SF07	Igf2bp2	Insulin-like growth factor 2 mRNA-binding protein 2	Mus musculus (Mouse)	PR
P34307	C06G4.1	KH domain-containing protein C06G4.1	Caenorhabditis elegans	PR