AiPD: Autoinhibited Protein Database

Q15365

Gene name	PCBP1
Protein name	Poly(rC)-binding protein 1
Names	Alpha-CP1, Heterogeneous nuclear ribonucleoprotein E1, hnRNP E1, Nucleic acid-binding protein SUB2.3
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5093
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

143-303 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

143-303 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q15365

Entry ID	Method	Resolution	Chain	Position	Source
1WVN	X-ray	210 A	A	279-356	PDB
1ZTG	X-ray	300 A	A/B/C/D	14-85	PDB
3VKE	X-ray	177 A	A/B/C/D	14-86	PDB
AF-Q15365-F1	Predicted				AlphaFoldDB

165 variants for Q15365

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
COSM3357605 CA204728 rs797044899 RCV000190723	184	Q>*	haematopoietic_and_lymphoid_tissue Inborn genetic diseases [Cosmic, ClinVar]	Yes	ClinGen cosmic curated ClinVar Ensembl dbSNP
rs753741941 CA1696805	2	D>H		No	ClinGen ExAC gnomAD
rs1188591740 CA347423081	3	A>V		No	ClinGen gnomAD
rs1476738568 CA347423087	4	G>A		No	ClinGen TOPMed gnomAD
rs1443310840 COSM1306952 CA347423089	5	V>M	Variant assessed as Somatic; impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1558626059 CA347423100	6	T>I		No	ClinGen Ensembl
CA49678185 rs918699478	8	S>T		No	ClinGen Ensembl
rs1317726539 CA347423116	9	G>R		No	ClinGen TOPMed
CA347423129 rs1170968182	11	N>H		No	ClinGen gnomAD
CA1696812 rs757731814	12	V>M		No	ClinGen ExAC TOPMed gnomAD
rs781557396 CA347423144	13	T>I		No	ClinGen ExAC TOPMed gnomAD
rs781557396 CA1696813	13	T>S		No	ClinGen ExAC TOPMed gnomAD
CA1696815 rs770327754	15	T>S		No	ClinGen ExAC
TCGA novel	28	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347423252 rs1204399147	29	I>M		No	ClinGen gnomAD
rs759459662 CA1696823	36	V>I		No	ClinGen ExAC gnomAD
CA1696824 rs765210138	38	R>K		No	ClinGen ExAC gnomAD
rs1379063769 CA347423340	42	E>V		No	ClinGen gnomAD
TCGA novel	46	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA49678281 rs1032661438	47	I>V		No	ClinGen TOPMed
rs558883932 CA347423401	51	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA347423399 rs1369752681	51	E>G		No	ClinGen TOPMed gnomAD
rs1323522259 CA347423396	51	E>Q		No	ClinGen gnomAD
rs1304980857 CA347423408	52	G>V		No	ClinGen gnomAD
CA347423416 rs1305278449	53	N>K		No	ClinGen TOPMed
CA1696830 rs781472547	55	P>A		No	ClinGen ExAC gnomAD
rs781472547 CA347423426	55	P>S		No	ClinGen ExAC gnomAD
rs774357592 CA1696836	70	K>R		No	ClinGen ExAC gnomAD
rs1311616841 CA347423561	75	I>V		No	ClinGen TOPMed
CA347423567 rs1365642765	76	I>V		No	ClinGen gnomAD
TCGA novel	83	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1418320015 CA347423622	83	I>T		No	ClinGen TOPMed
CA1696840 rs759354974	83	I>V		No	ClinGen ExAC gnomAD
CA1696841 rs148864700	84	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1696843 rs762938579	87	M>K		No	ClinGen ExAC gnomAD
CA347423653 rs1180188717	88	T>P		No	ClinGen TOPMed gnomAD
CA1696845 rs751106983	90	S>I		No	ClinGen ExAC TOPMed gnomAD
rs200188120 CA1696846	91	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA347423692 rs1572929288	94	S>G		No	ClinGen Ensembl
rs1572929297 CA347423707	96	P>T		No	ClinGen Ensembl
rs780346294 CA1696850	99	T>I		No	ClinGen ExAC gnomAD
CA347423732 COSM195129 rs1422143141	100	L>P	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1422143141 COSM287208 CA347423731	100	L>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
TCGA novel	101	R>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1572929308 CA347423757	104	V>G		No	ClinGen Ensembl
CA1696855 rs772234402	107	T>P		No	ClinGen ExAC gnomAD
rs1572929317 CA347423806	112	L>P		No	ClinGen Ensembl
CA347423835 rs1355669818	117	G>R		No	ClinGen TOPMed gnomAD
rs1355669818 CA347423837	117	G>W		No	ClinGen TOPMed gnomAD
rs1572929342 CA347423843	118	C>G		No	ClinGen Ensembl
CA347423847 rs1572929350	118	C>W		No	ClinGen Ensembl
rs917212328 CA49678431	118	C>Y		No	ClinGen TOPMed
rs559670831 CA1696862	119	K>E		No	ClinGen 1000Genomes ExAC gnomAD
CA1696863 rs761353196	120	I>V		No	ClinGen ExAC gnomAD
rs1329942048 CA347423865	121	K>R		No	ClinGen gnomAD
rs559776726 CA49678449	128	G>R		No	ClinGen gnomAD
TCGA novel	132	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1258371259 CA347423948	133	V>E		No	ClinGen gnomAD
rs1476288350 CA347423960	135	G>E		No	ClinGen gnomAD
rs766734210 CA1696867	137	M>I		No	ClinGen ExAC gnomAD
rs11545479 CA49678464	142	T>S		No	ClinGen Ensembl
TCGA novel	143	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	144	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347424067 rs1475524946	152	P>A		No	ClinGen TOPMed
TCGA novel	152	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347424076 rs879000148	153	Q>L		No	ClinGen gnomAD
CA49678486 rs879000148	153	Q>R		No	ClinGen gnomAD
TCGA novel	157	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1205496619 CA347424108	158	C>Y		No	ClinGen TOPMed
rs1234244836 CA347424118	159	V>G		No	ClinGen gnomAD
rs1320264926 CA347424128	161	Q>E		No	ClinGen TOPMed
CA347424169 rs1232725987	166	M>I		No	ClinGen TOPMed
TCGA novel	168	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1696882 rs368303566	169	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA
TCGA novel	173	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766015430 CA347424223	175	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs766015430 CA1696884	175	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1390117687 CA347424230 COSM134027	176	G>E	skin [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1572929457 CA347424239	177	R>S		No	ClinGen Ensembl
CA49678554 rs1053750582	178	V>I		No	ClinGen TOPMed
rs1395096394 CA347424251	179	M>I		No	ClinGen gnomAD
rs1444004391 CA347424257	180	T>S		No	ClinGen TOPMed
CA49678565 rs893719521	181	I>V		No	ClinGen TOPMed gnomAD
CA347424275 rs1572929485	183	Y>S		No	ClinGen Ensembl
rs371489521 CA1696888	187	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs758760675 CA1696889	188	A>S		No	ClinGen ExAC gnomAD
CA49678620 rs996074850	189	S>G		No	ClinGen TOPMed
rs1316876821 CA347424315	189	S>T		No	ClinGen Ensembl
rs1222130945 CA347424330	191	P>L		No	ClinGen gnomAD
rs1350769387 CA347424327	191	P>S		No	ClinGen gnomAD
rs138166426 CA347424342	193	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs890103158 CA49678640	193	I>T		No	ClinGen TOPMed gnomAD
CA347424337 rs1344651413	193	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	197	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778506215 CA1696896	202	S>R		No	ClinGen ExAC gnomAD
CA49678665 rs973977496	203	D>E		No	ClinGen TOPMed
CA347424413 rs748131071	204	A>P		No	ClinGen ExAC TOPMed gnomAD
rs748131071 CA1696897	204	A>T		No	ClinGen ExAC TOPMed gnomAD
CA49678672 rs707712	205	A>E		No	ClinGen gnomAD
CA49678680 rs707712	205	A>G		No	ClinGen gnomAD
CA49678683 rs707712	205	A>V		No	ClinGen gnomAD
rs1400880070 CA347424420	206	G>S		No	ClinGen gnomAD
CA347424430 rs1242735731	207	Y>C		No	ClinGen TOPMed
rs772845567 CA1696899	208	P>L		No	ClinGen ExAC gnomAD
CA49678706 rs991725375	209	H>L		No	ClinGen TOPMed
CA1696901 rs770617241	209	H>Y		No	ClinGen ExAC gnomAD
rs1327061930 CA347424456	211	T>I		No	ClinGen gnomAD
CA1696902 rs776286045	212	H>L		No	ClinGen ExAC gnomAD
rs1440700316 CA347424466	213	D>N		No	ClinGen gnomAD
rs1477971437 CA347424501	218	P>L		No	ClinGen TOPMed gnomAD
CA1696906 rs775654841 COSM3933664	218	P>S	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1212817547 CA347424503	219	L>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA347424515 rs1364288895	221	A>T		No	ClinGen TOPMed
CA1696909 rs764481901	222	Y>C		No	ClinGen ExAC gnomAD
CA347424524 rs764481901	222	Y>F		No	ClinGen ExAC gnomAD
rs764481901 CA1696908	222	Y>S		No	ClinGen ExAC gnomAD
CA1696910 COSM1306953 rs757437176	223	S>L	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA1696912 rs750679674	224	I>V		No	ClinGen ExAC gnomAD
rs756348407 CA347424544	225	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1460640524 COSM3695669 CA347424547	226	G>R	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1572929627 CA347424553	227	Q>E		No	ClinGen Ensembl
rs758201867 CA347424572	229	T>I		No	ClinGen ExAC TOPMed gnomAD
CA1696914 rs758201867	229	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1393367048 CA347424585	231	S>F		No	ClinGen gnomAD
CA347424591 rs1408660384	232	P>L		No	ClinGen gnomAD
TCGA novel	232	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1336351141 CA347424592	233	L>F		No	ClinGen gnomAD
CA49678784 rs13856	234	D>E		No	ClinGen Ensembl
rs1291572286 CA347424638	240	Q>E		No	ClinGen gnomAD
rs777548378 CA1696917	242	A>V		No	ClinGen ExAC gnomAD
rs1242892765 CA347424667	244	Q>R		No	ClinGen TOPMed
CA1696921 rs745530090	249	A>T		No	ClinGen ExAC TOPMed gnomAD
CA49678800 rs548418658	250	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
TCGA novel	251	M>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1428157057 CA347424726	252	H>P		No	ClinGen gnomAD
rs769313762 CA1696923	252	H>Q		No	ClinGen ExAC gnomAD
CA347424724 rs1234656447	252	H>Y		No	ClinGen TOPMed
rs1438384088 CA347424731	253	G>R		No	ClinGen gnomAD
rs762345671 CA347424760	257	F>L		No	ClinGen ExAC gnomAD
rs1384998401 CA347424778	260	I>T		No	ClinGen TOPMed
TCGA novel	263	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs931911383 CA49678834	264	S>C		No	ClinGen TOPMed
CA49678835 rs1050348341	267	V>A		No	ClinGen TOPMed gnomAD
CA347424826 rs1050348341	267	V>G		No	ClinGen TOPMed gnomAD
TCGA novel	271	W>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	271	W>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1379561087 CA347424868	273	S>T		No	ClinGen TOPMed
CA1696933 rs752585934	275	D>A		No	ClinGen ExAC
rs1311106323 CA347424886	276	A>T		No	ClinGen gnomAD
rs1374952874 CA347424891	276	A>V		No	ClinGen gnomAD
TCGA novel	291	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757124422 CA1696937	293	C>Y		No	ClinGen ExAC gnomAD
rs1484974599 CA347425049	300	A>S		No	ClinGen TOPMed
CA347425050 rs1484974599	300	A>T		No	ClinGen TOPMed
rs1257827236 CA347425093	306	R>C		No	ClinGen gnomAD
CA1696941 rs779598445	307	Q>H		No	ClinGen ExAC gnomAD
TCGA novel	311	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347425237 rs1451829726	327	V>I		No	ClinGen gnomAD
rs1383044449 CA347425300	337	S>G		No	ClinGen gnomAD
CA892520037 rs1267514008	344	N>*		No	ClinGen Ensembl
rs759734451 CA1696951	344	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1347142391 CA347425370	347	L>H		No	ClinGen gnomAD
rs1348055901 CA347425407	353	M>V		No	ClinGen gnomAD
TCGA novel	355	C>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	356	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with Q15365

14 regional properties for Q15365

Type	Name	Position	InterPro Accession
repeat	HAT (Half-A-TPR) repeat	56 - 88	IPR003107-1
repeat	HAT (Half-A-TPR) repeat	90 - 122	IPR003107-2
repeat	HAT (Half-A-TPR) repeat	124 - 156	IPR003107-3
repeat	HAT (Half-A-TPR) repeat	158 - 189	IPR003107-4
repeat	HAT (Half-A-TPR) repeat	191 - 222	IPR003107-5
repeat	HAT (Half-A-TPR) repeat	224 - 259	IPR003107-6
repeat	HAT (Half-A-TPR) repeat	261 - 295	IPR003107-7
repeat	HAT (Half-A-TPR) repeat	339 - 373	IPR003107-8
repeat	HAT (Half-A-TPR) repeat	383 - 419	IPR003107-9
repeat	HAT (Half-A-TPR) repeat	421 - 452	IPR003107-10
repeat	HAT (Half-A-TPR) repeat	454 - 486	IPR003107-11
repeat	HAT (Half-A-TPR) repeat	488 - 522	IPR003107-12
repeat	HAT (Half-A-TPR) repeat	524 - 555	IPR003107-13
repeat	HAT (Half-A-TPR) repeat	567 - 605	IPR003107-14

Functions

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm	Loosely bound in the nucleus (PubMed:7607214) May shuttle between the nucleus and the cytoplasm (PubMed:7607214)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic ribonucleoprotein granule	A ribonucleoprotein granule located in the cytoplasm.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex	A macromolecular complex that contains both RNA and protein molecules.

6 GO annotations of molecular function

Name	Definition
cadherin binding	Binding to cadherin, a type I membrane protein involved in cell adhesion.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
mRNA binding	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
RNA binding	Binding to an RNA molecule or a portion thereof.
sequence-specific single stranded DNA binding	Binding to single-stranded DNA of a specific nucleotide composition.
single-stranded DNA binding	Binding to single-stranded DNA.

4 GO annotations of biological process

Name	Definition
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of gene expression	Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of RNA metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
viral RNA genome replication	The replication of a viral RNA genome.

6 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9NZI8	IGF2BP1	Insulin-like growth factor 2 mRNA-binding protein 1	Homo sapiens (Human)	PR
O00425	IGF2BP3	Insulin-like growth factor 2 mRNA-binding protein 3	Homo sapiens (Human)	PR
Q9Y6M1	IGF2BP2	Insulin-like growth factor 2 mRNA-binding protein 2	Homo sapiens (Human)	PR
Q96I24	FUBP3	Far upstream element-binding protein 3	Homo sapiens (Human)	PR
P60335	Pcbp1	Poly(rC)-binding protein 1	Mus musculus (Mouse)	PR
P34307	C06G4.1	KH domain-containing protein C06G4.1	Caenorhabditis elegans	PR

10	20	30	40	50	60
MDAGVTESGL	NVTLTIRLLM	HGKEVGSIIG	KKGESVKRIR	EESGARINIS	EGNCPERIIT
70	80	90	100	110	120
LTGPTNAIFK	AFAMIIDKLE	EDINSSMTNS	TAASRPPVTL	RLVVPATQCG	SLIGKGGCKI
130	140	150	160	170	180
KEIRESTGAQ	VQVAGDMLPN	STERAITIAG	VPQSVTECVK	QICLVMLETL	SQSPQGRVMT
190	200	210	220	230	240
IPYQPMPASS	PVICAGGQDR	CSDAAGYPHA	THDLEGPPLD	AYSIQGQHTI	SPLDLAKLNQ
250	260	270	280	290	300
VARQQSHFAM	MHGGTGFAGI	DSSSPEVKGY	WASLDASTQT	THELTIPNNL	IGCIIGRQGA
310	320	330	340	350
NINEIRQMSG	AQIKIANPVE	GSSGRQVTIT	GSAASISLAQ	YLINARLSSE	KGMGCS