Q5SF07

PR
Gene name
Igf2bp2 (Imp2, Vickz2)
Protein name
Insulin-like growth factor 2 mRNA-binding protein 2
Names
IGF2 mRNA-binding protein 2, IMP-2, IGF-II mRNA-binding protein 2, VICKZ family member 2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:319765
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

125-592 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5SF07

Entry ID Method Resolution Chain Position Source
AF-Q5SF07-F1 Predicted AlphaFoldDB

26 variants for Q5SF07

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389408204 94 Q>* No EVA
rs3389424681 136 A>D No EVA
rs3389402761 143 H>Y No EVA
rs3389414658 144 Q>K No EVA
rs3389377131 255 M>L No EVA
rs3405081631 261 E>A No EVA
rs3389408156 267 E>D No EVA
rs3389388079 280 G>S No EVA
rs3389357904 281 R>G No EVA
rs3410377128 283 I>F No EVA
rs3389405651 345 D>Y No EVA
rs3389424691 465 S>T No EVA
rs3406733979 473 G>D No EVA
rs3406733925 475 P>H No EVA
rs3406821216 477 A>D No EVA
rs3389402447 516 R>W No EVA
rs3389412153 558 F>Y No EVA
rs3389402477 565 Q>E No EVA
rs49000816 573 Q>H No EVA
rs3389324550 576 K>SDG* No EVA
rs3389399457 578 Q>* No EVA
rs3389388081 579 E>G No EVA
rs3389357926 580 Q>L No EVA
rs3389402505 584 Q>H No EVA
rs3389401314 588 P>Q No EVA
rs46126959 591 S>N No EVA

No associated diseases with Q5SF07

11 regional properties for Q5SF07

Type Name Position InterPro Accession
domain RNA recognition motif domain 3 - 76 IPR000504-1
domain RNA recognition motif domain 82 - 157 IPR000504-2
domain K Homology domain 185 - 256 IPR004087-1
domain K Homology domain 266 - 339 IPR004087-2
domain K Homology domain 419 - 490 IPR004087-3
domain K Homology domain 501 - 573 IPR004087-4
domain K Homology domain, type 1 189 - 253 IPR004088-1
domain K Homology domain, type 1 271 - 335 IPR004088-2
domain K Homology domain, type 1 422 - 485 IPR004088-3
domain K Homology domain, type 1 506 - 570 IPR004088-4
domain IGF2BP2, RNA recognition motif 1 2 - 78 IPR034843

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Cytoplasm, P-body
  • Cytoplasm, Stress granule
  • Localized in cytoplasmic mRNP granules containing untranslated mRNAs
  • Localizes at the connecting piece and the tail of the spermatozoa
  • In response to cellular stress, such as oxidative stress, recruited to stress granules (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
P-body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.

4 GO annotations of molecular function

Name Definition
mRNA 3'-UTR binding Binding to a 3' untranslated region of an mRNA molecule.
mRNA 5'-UTR binding Binding to an mRNA molecule at its 5' untranslated region.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
N6-methyladenosine-containing RNA binding Binding to an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs.

6 GO annotations of biological process

Name Definition
CRD-mediated mRNA stabilization An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD).
mRNA transport The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of RNA metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
regulation of translation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O42254 IGF2BP1 Insulin-like growth factor 2 mRNA-binding protein 1 Gallus gallus (Chicken) PR
Q5ZLP8 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 Gallus gallus (Chicken) PR
O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 Homo sapiens (Human) PR
Q9NZI8 IGF2BP1 Insulin-like growth factor 2 mRNA-binding protein 1 Homo sapiens (Human) PR
Q9Y6M1 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 Homo sapiens (Human) PR
O88477 Igf2bp1 Insulin-like growth factor 2 mRNA-binding protein 1 Mus musculus (Mouse) PR
Q9CPN8 Igf2bp3 Insulin-like growth factor 2 mRNA-binding protein 3 Mus musculus (Mouse) PR
P60335 Pcbp1 Poly(rC)-binding protein 1 Mus musculus (Mouse) PR
Q8CGX0 Igf2bp1 Insulin-like growth factor 2 mRNA-binding protein 1 Rattus norvegicus (Rat) PR
Q08CK7 igf2bp1 Insulin-like growth factor 2 mRNA-binding protein 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MMNKLYIGNL SPAVTADDLR QLFGDRKLPL AGQVLLKSGY AFVDYPDQNW AIRAIETLSG
70 80 90 100 110 120
KVELHGKIME VDYSVSKKLR SRRIQIRNIP PHLQWEVLDG LLAEYGTVEN VEQVNTDTET
130 140 150 160 170 180
AVVNVTYMTR EEAKLAIEKL SGHQFEDYSF KISYIPDEEV SSPSPPHRAR EQGHGPGSSS
190 200 210 220 230 240
QARQIDFPLR ILVPTQFVGA IIGKEGLTIK NITKQTQSRV DIHRKENSGA AEKPVTIHAT
250 260 270 280 290 300
PEGTSEACRM ILEIMQKEAD ETKLAEEVPL KILAHNGFVG RLIGKEGRNL KKIEHETGTK
310 320 330 340 350 360
ITISSLQDLS IYNPERTITV RGTIEACANA EIEIMKKLRE AFENDMLAVN QQANLIPGLN
370 380 390 400 410 420
LSALGIFSTG LSVLPPPAGP RGVPPSPPYH PFATHSGYFS SLYPHHHFGP FPHHHSYPEQ
430 440 450 460 470 480
ETVSLFIPTQ AVGAIIGKKG AHIKQLARFA GASIKIAPAE GPDVSERMVI ITGPPEAQFK
490 500 510 520 530 540
AQGRIFGKLK EENFFNPKEE VKLEAHIRVP SSTAGRVIGK GGKTVNELQN LTSAEVIVPR
550 560 570 580 590
DQTPDENEEV IVRIIGHFFA SQTAQRKIRE IVQQVKQQEQ RYPQGVAPQR SK