Q5ZLP8
PR
Gene name |
IGF2BP3 (VICKZ3, RCJMB04_5e15) |
Protein name |
Insulin-like growth factor 2 mRNA-binding protein 3 |
Names |
IGF2 mRNA-binding protein 3, IMP-3, IGF-II mRNA-binding protein 3, VICKZ family member 3 |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:420617 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5ZLP8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5ZLP8-F1 | Predicted | AlphaFoldDB |
No variants for Q5ZLP8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5ZLP8 | |||||
No associated diseases with Q5ZLP8
10 regional properties for Q5ZLP8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RNA recognition motif domain | 2 - 75 | IPR000504-1 |
| domain | RNA recognition motif domain | 81 - 156 | IPR000504-2 |
| domain | K Homology domain | 195 - 266 | IPR004087-1 |
| domain | K Homology domain | 276 - 349 | IPR004087-2 |
| domain | K Homology domain | 408 - 479 | IPR004087-3 |
| domain | K Homology domain | 490 - 562 | IPR004087-4 |
| domain | K Homology domain, type 1 | 199 - 263 | IPR004088-1 |
| domain | K Homology domain, type 1 | 281 - 345 | IPR004088-2 |
| domain | K Homology domain, type 1 | 412 - 475 | IPR004088-3 |
| domain | K Homology domain, type 1 | 495 - 559 | IPR004088-4 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic stress granule | A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| P-body | A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA 3'-UTR binding | Binding to a 3' untranslated region of an mRNA molecule. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| N6-methyladenosine-containing RNA binding | Binding to an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| CRD-mediated mRNA stabilization | An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD). |
| mRNA transport | The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| regulation of RNA metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA. |
| regulation of translation | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O42254 | IGF2BP1 | Insulin-like growth factor 2 mRNA-binding protein 1 | Gallus gallus (Chicken) | PR |
| Q9NZI8 | IGF2BP1 | Insulin-like growth factor 2 mRNA-binding protein 1 | Homo sapiens (Human) | PR |
| Q9Y6M1 | IGF2BP2 | Insulin-like growth factor 2 mRNA-binding protein 2 | Homo sapiens (Human) | PR |
| O00425 | IGF2BP3 | Insulin-like growth factor 2 mRNA-binding protein 3 | Homo sapiens (Human) | PR |
| O88477 | Igf2bp1 | Insulin-like growth factor 2 mRNA-binding protein 1 | Mus musculus (Mouse) | PR |
| Q5SF07 | Igf2bp2 | Insulin-like growth factor 2 mRNA-binding protein 2 | Mus musculus (Mouse) | PR |
| Q9CPN8 | Igf2bp3 | Insulin-like growth factor 2 mRNA-binding protein 3 | Mus musculus (Mouse) | PR |
| Q8CGX0 | Igf2bp1 | Insulin-like growth factor 2 mRNA-binding protein 1 | Rattus norvegicus (Rat) | PR |
| Q08CK7 | igf2bp1 | Insulin-like growth factor 2 mRNA-binding protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNKLYIGNLG | ENVSPLDLES | LFKDSKIPFS | GQFLVKTGYA | FVDCPDESWA | MKAIEALSGK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VELHGKLIEV | EHSVPKRQRS | RKLQIRNIPP | HLQWEVLDSL | LAQYGTVENC | EQVNTDTETA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VVNVTYGNKD | QARQAIEKLN | GFQLENYSLK | VAYIPDEMAA | QQPPQQHPQG | RRGFGQRGPP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RQGSPSATTR | QKPQSDVPLR | MLVPTQFVGA | IIGKEGATIR | NITKQTQSKI | DIHRKENAGA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AEKPITIHST | PEGCSTACKI | IMEIMQKEAQ | DTKFTEEIPL | KILAHNNFVG | RLIGKEGRNL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KKIEQDTDTK | ITISPLQDLT | LYNPERTITV | KGSIETCAKA | EEEIMKKIRE | SYENDIAAMN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LQAHLIPGLN | LNALGLFPPS | SSGIPPPAVS | VASAAAAASY | PPFGQQPESE | TVHLFIPALA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VGAIIGKQGQ | HIKQLSRFAG | ASIKIAPAEG | PDAKLRMVII | TGPPEAQFKA | QGRIYGKLKE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ENFFGPKEEV | KLEAHIKVPS | YAAGRVIGKG | GKTVNELQNL | TSAEVVVPRD | QTPDENDQVV |
| 550 | 560 | 570 | 580 | ||
| VKITGHFYAC | QLAQRKIQEI | LAQVRRQQQQ | QKTLQSGQPQ | PRRK |