O42254

PR
Gene name
IGF2BP1 (VICKZ1, ZBP1)
Protein name
Insulin-like growth factor 2 mRNA-binding protein 1
Names
IGF2 mRNA-binding protein 1, IMP-1, IGF-II mRNA-binding protein 1, VICKZ family member 1, Zip-code binding polypeptide, Zipcode-binding protein 1, ZBP-1
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:395953
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

130-211 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for O42254

Entry ID Method Resolution Chain Position Source
2N8L NMR - A 387-573 PDB
2N8M NMR - A 387-573 PDB
8COO NMR - A 387-573 PDB
AF-O42254-F1 Predicted AlphaFoldDB

No variants for O42254

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O42254

No associated diseases with O42254

12 regional properties for O42254

Type Name Position InterPro Accession
domain RNA recognition motif domain 2 - 75 IPR000504-1
domain RNA recognition motif domain 81 - 156 IPR000504-2
domain K Homology domain 194 - 265 IPR004087-1
domain K Homology domain 275 - 348 IPR004087-2
domain K Homology domain 403 - 474 IPR004087-3
domain K Homology domain 485 - 557 IPR004087-4
domain K Homology domain, type 1 198 - 262 IPR004088-1
domain K Homology domain, type 1 280 - 344 IPR004088-2
domain K Homology domain, type 1 406 - 470 IPR004088-3
domain K Homology domain, type 1 489 - 553 IPR004088-4
domain IGF2BP1, RNA recognition motif 1 1 - 77 IPR034837
domain IGF2BP1, RNA recognition motif 2 81 - 156 IPR034842

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Cytoplasm, perinuclear region
  • Cytoplasm, P-body
  • Cytoplasm, Stress granule
  • Cell projection, growth cone
  • Cell projection, filopodium
  • Cell projection, lamellipodium
  • In the nucleus, located in discrete foci, coinciding with the sites of ACTB transcription
  • Export from the nucleus is mediated by XPO1
  • In the cytoplasm, colocalizes with ACTB mRNA at the leading edge, in growth cone filopodia and along neurites
  • In these locations, also colocalizes with microtubules
  • Colocalization with ACTB mRNA is partially lost at the cell periphery, suggesting release of the transcript
  • In neuronal processes, exhibits fast retrograde and anterograde movements, when associated with ACTB mRNA; this motility is lost when the association is inhibited
  • In migrating fibroblasts, localizes not only to leading edges, but also to retracting tails
  • In response to cellular stress, such as oxidative stress or heat shock, recruited to stress granules
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

10 GO annotations of cellular component

Name Definition
CRD-mediated mRNA stability complex A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
filopodium Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
growth cone The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
lamellipodium A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
P-body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

3 GO annotations of molecular function

Name Definition
mRNA 3'-UTR binding Binding to a 3' untranslated region of an mRNA molecule.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
N6-methyladenosine-containing RNA binding Binding to an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs.

7 GO annotations of biological process

Name Definition
CRD-mediated mRNA stabilization An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD).
mRNA transport The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
negative regulation of translation Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
positive regulation of neuron projection development Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of RNA metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5ZLP8 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 Gallus gallus (Chicken) PR
O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 Homo sapiens (Human) PR
Q9Y6M1 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 Homo sapiens (Human) PR
Q9NZI8 IGF2BP1 Insulin-like growth factor 2 mRNA-binding protein 1 Homo sapiens (Human) PR
Q5SF07 Igf2bp2 Insulin-like growth factor 2 mRNA-binding protein 2 Mus musculus (Mouse) PR
Q9CPN8 Igf2bp3 Insulin-like growth factor 2 mRNA-binding protein 3 Mus musculus (Mouse) PR
O88477 Igf2bp1 Insulin-like growth factor 2 mRNA-binding protein 1 Mus musculus (Mouse) PR
Q8CGX0 Igf2bp1 Insulin-like growth factor 2 mRNA-binding protein 1 Rattus norvegicus (Rat) PR
Q08CK7 igf2bp1 Insulin-like growth factor 2 mRNA-binding protein 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MNKLYIGNLN ESVTPADLEK VFNDHKISFS GQFLVKSGYA FVDCPDEQWA MKAIETFSGK
70 80 90 100 110 120
VELHGKQLEI EHSVPKKQRS RKIQIRNIPP QLRWEVLDGL LAQYGTVENC EQVNTDSETA
130 140 150 160 170 180
VVNVTYTNRE QTRQAIMKLN GHQLENHVLK VSYIPDEQSV QGPENGRRGG FGARGAPRQG
190 200 210 220 230 240
SPVTAGAPVK QQPVDIPLRL LVPTQYVGAI IGKEGATIRN ITKQTQSKID VHRKENAGAA
250 260 270 280 290 300
EKAISIHSTP EGCSAACKMI LEIMQKEAKD TKTADEVPLK ILAHNNFVGR LIGKEGRNLK
310 320 330 340 350 360
KVEQDTETKI TISSLQDLTL YNPERTITVK GSIENCCKAE QEIMKKVREA YENDVAAMSL
370 380 390 400 410 420
QSHLIPGLNL AAVGLFPASS NAVPPPPSSV SGAAPYSSFM PPEQETVHVF IPAQAVGAII
430 440 450 460 470 480
GKKGQHIKQL SRFASASIKI APPETPDSKV RMVVITGPPE AQFKAQGRIY GKLKEENFFG
490 500 510 520 530 540
PKEEVKLETH IRVPASAAGR VIGKGGKTVN ELQNLTAAEV VVPRDQTPDE NEQVIVKIIG
550 560 570
HFYASQMAQR KIRDILAQVK QQHQKGQSGQ LQARRK