Q9MAU6
PR
Gene name |
PDIL2-2 (PDI10, PDIL5-1, At1g04980, F13M7.3) |
Protein name |
Protein disulfide-isomerase like 2-2 |
Names |
AtPDIL2-2, Protein disulfide-isomerase 10, PDI10, Protein disulfide-isomerase like 5-1, AtPDIL5-1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G04980 |
EC number |
5.3.4.1: Transposing S-S bonds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9MAU6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9MAU6-F1 | Predicted | AlphaFoldDB |
23 variants for Q9MAU6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH10599926 | 14 | C>F | No | 1000Genomes | |
| ENSVATH04521390 | 30 | S>T | No | 1000Genomes | |
| tmp_1_1416027_A_G | 32 | S>P | No | 1000Genomes | |
| ENSVATH00006390 | 35 | L>I | No | 1000Genomes | |
| ENSVATH04521389 | 46 | V>G | No | 1000Genomes | |
| ENSVATH01013334 | 84 | T>P | No | 1000Genomes | |
| tmp_1_1415713_C_G | 86 | A>P | No | 1000Genomes | |
| tmp_1_1415700_G_A | 90 | A>V | No | 1000Genomes | |
| ENSVATH00006389 | 150 | S>T | No | 1000Genomes | |
| tmp_1_1415324_T_A | 154 | N>Y | No | 1000Genomes | |
| tmp_1_1415063_T_C | 206 | E>G | No | 1000Genomes | |
| tmp_1_1414687_A_G | 275 | S>P | No | 1000Genomes | |
| ENSVATH01013330 | 339 | V>G | No | 1000Genomes | |
| tmp_1_1414286_C_A | 343 | A>S | No | 1000Genomes | |
| tmp_1_1414277_G_A | 346 | Q>* | No | 1000Genomes | |
| tmp_1_1414258_C_T | 352 | R>H | No | 1000Genomes | |
| ENSVATH13853662 | 370 | K>I | No | 1000Genomes | |
| tmp_1_1413999_G_C | 405 | T>S | No | 1000Genomes | |
| ENSVATH13853661 | 425 | D>N | No | 1000Genomes | |
| ENSVATH00006388 | 433 | M>K | No | 1000Genomes | |
| tmp_1_1413891_G_A | 441 | T>I | No | 1000Genomes | |
| tmp_1_1413883_T_A | 444 | K>* | No | 1000Genomes | |
| ENSVATH10599840 | 444 | K>N | No | 1000Genomes |
No associated diseases with Q9MAU6
6 regional properties for Q9MAU6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein disulfide-isomerase, thioredoxin-like domain | 37 - 136 | IPR005788-1 |
| domain | Protein disulfide-isomerase, thioredoxin-like domain | 172 - 272 | IPR005788-2 |
| domain | Thioredoxin domain | 26 - 139 | IPR013766-1 |
| domain | Thioredoxin domain | 161 - 275 | IPR013766-2 |
| conserved_site | Thioredoxin, conserved site | 54 - 72 | IPR017937-1 |
| conserved_site | Thioredoxin, conserved site | 189 - 207 | IPR017937-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 5.3.4.1 | Transposing S-S bonds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum lumen | The volume enclosed by the membranes of the endoplasmic reticulum. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plant-type cell wall | A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein disulfide isomerase activity | Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins. |
| protein-disulfide reductase activity | Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| response to endoplasmic reticulum stress | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12404 | MPD1 | Protein disulfide-isomerase MPD1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q2KIL5 | PDIA5 | Protein disulfide-isomerase A5 | Bos taurus (Bovine) | PR |
| Q8N807 | PDILT | Protein disulfide-isomerase-like protein of the testis | Homo sapiens (Human) | PR |
| Q15084 | PDIA6 | Protein disulfide-isomerase A6 | Homo sapiens (Human) | PR |
| Q921X9 | Pdia5 | Protein disulfide-isomerase A5 | Mus musculus (Mouse) | PR |
| Q922R8 | Pdia6 | Protein disulfide-isomerase A6 | Mus musculus (Mouse) | PR |
| Q5I0H9 | Pdia5 | Protein disulfide-isomerase A5 | Rattus norvegicus (Rat) | PR |
| Q63081 | Pdia6 | Protein disulfide-isomerase A6 | Rattus norvegicus (Rat) | PR |
| Q10N04 | PDIL5-1 | Protein disulfide isomerase-like 5-1 | Oryza sativa subsp japonica (Rice) | PR |
| Q67UF5 | PDIL2-3 | Protein disulfide isomerase-like 2-3 | Oryza sativa subsp japonica (Rice) | PR |
| Q8GYD1 | PDIL5-1 | Protein disulfide-isomerase 5-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O48773 | PDIL2-3 | Protein disulfide-isomerase 2-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MERKMYKSTV | FPICCLLFAL | FDRGNALYGS | SSPVLQLTPS | NFKSKVLNSN | GVVLVEFFAP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WCGHCQSLTP | TWEKVASTLK | GIATVAAIDA | DAHKSVSQDY | GVRGFPTIKV | FVPGKPPIDY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QGARDAKSIS | QFAIKQIKAL | LKDRLDGKTS | GTKNGGGSSE | KKKSEPSASV | ELNSSNFDEL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VTESKELWIV | EFFAPWCGHC | KKLAPEWKKA | ANNLKGKVKL | GHVNCDAEQS | IKSRFKVQGF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PTILVFGSDK | SSPVPYEGAR | SASAIESFAL | EQLESNAGPA | EVTELTGPDV | MEDKCGSAAI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CFVSFLPDIL | DSKAEGRNKY | LEMLLSVADK | FKKDPYGFVW | VAAGKQPDLE | KRVGVGGYGY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PAMVALNAKK | GAYAPLKSGF | EVKHLKDFVK | EAAKGGKGNL | PIDGTMEIVK | TEAWDGKDGE |
| 430 | 440 | ||||
| VVDADEFSLE | DLMGNDDEAS | TESKDDL |