AiPD: Autoinhibited Protein Database

Gene name	PDIL2-3 (PDI9, PDIL5-2, At2g32920, T21L14.14)
Protein name	Protein disulfide-isomerase 2-3
Names	AtPDIL2-3, Protein disulfide-isomerase 5-2, AtPDIL5-2, Protein disulfide-isomerase 9, PDI9
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT2G32920
EC number	5.3.4.1: Transposing S-S bonds
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

112-197 (Predicted disordered autoinhibitory region) PR

112-197 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O48773-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH13512079	13	T>I	No	1000Genomes
ENSVATH01941831	27	G>E	No	1000Genomes
tmp_2_13965310_C_T	33	V>I	No	1000Genomes
ENSVATH05646871	49	G>A	No	1000Genomes
tmp_2_13965070_C_T	51	V>I	No	1000Genomes
tmp_2_13965015_G_T	69	T>K	No	1000Genomes
tmp_2_13964176_C_G	137	G>A	No	1000Genomes
tmp_2_13964157_C_A	143	L>F	No	1000Genomes
ENSVATH01941827	149	P>S	No	1000Genomes
tmp_2_13964135_C_T	151	G>R	No	1000Genomes
tmp_2_13964111_A_G	159	S>P	No	1000Genomes
tmp_2_13964107_T_C	160	E>G	No	1000Genomes
ENSVATH05646857	168	N>K	No	1000Genomes
tmp_2_13963562_G_A	225	S>L	No	1000Genomes
tmp_2_13963512_C_T	242	G>S	No	1000Genomes
tmp_2_13963460_G_C	259	A>G	No	1000Genomes
ENSVATH13512062	269	E>D	No	1000Genomes
ENSVATH05646850	278	T>I	No	1000Genomes
tmp_2_13963265_C_A	291	G>V	No	1000Genomes
ENSVATH00257731	309	A>V	No	1000Genomes
ENSVATH01941821	337	A>G	No	1000Genomes
tmp_2_13962885_C_T	343	D>N	No	1000Genomes
tmp_2_13962806_G_T	369	A>D	No	1000Genomes
ENSVATH14579742	379	H>N	No	1000Genomes
ENSVATH01941820	401	P>L	No	1000Genomes
ENSVATH05646840	406	T>S	No	1000Genomes
ENSVATH09395797	433	A>T	No	1000Genomes
tmp_2_13962518_G_A	436	S>F	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Protein disulfide-isomerase, thioredoxin-like domain	35 - 134	IPR005788-1
domain	Protein disulfide-isomerase, thioredoxin-like domain	167 - 266	IPR005788-2
domain	Thioredoxin domain	24 - 136	IPR013766-1
domain	Thioredoxin domain	154 - 269	IPR013766-2
conserved_site	Thioredoxin, conserved site	52 - 70	IPR017937-1
conserved_site	Thioredoxin, conserved site	184 - 202	IPR017937-2

		Description
EC Number	5.3.4.1	Transposing S-S bonds
Subcellular Localization	Endoplasmic reticulum lumen
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum lumen	The volume enclosed by the membranes of the endoplasmic reticulum.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
plant-type vacuole	A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana.

Name	Definition
protein disulfide isomerase activity	Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
protein-disulfide reductase activity	Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.

Name	Definition
response to endoplasmic reticulum stress	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q12404	MPD1	Protein disulfide-isomerase MPD1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q2KIL5	PDIA5	Protein disulfide-isomerase A5	Bos taurus (Bovine)	PR
Q8N807	PDILT	Protein disulfide-isomerase-like protein of the testis	Homo sapiens (Human)	PR
Q15084	PDIA6	Protein disulfide-isomerase A6	Homo sapiens (Human)	PR
Q921X9	Pdia5	Protein disulfide-isomerase A5	Mus musculus (Mouse)	PR
Q922R8	Pdia6	Protein disulfide-isomerase A6	Mus musculus (Mouse)	PR
Q5I0H9	Pdia5	Protein disulfide-isomerase A5	Rattus norvegicus (Rat)	PR
Q63081	Pdia6	Protein disulfide-isomerase A6	Rattus norvegicus (Rat)	PR
Q10N04	PDIL5-1	Protein disulfide isomerase-like 5-1	Oryza sativa subsp japonica (Rice)	PR
Q67UF5	PDIL2-3	Protein disulfide isomerase-like 2-3	Oryza sativa subsp japonica (Rice)	PR
Q8GYD1	PDIL5-1	Protein disulfide-isomerase 5-1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9MAU6	PDIL2-2	Protein disulfide-isomerase like 2-2	Arabidopsis thaliana (Mouse-ear cress)	PR