Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q10N04

Entry ID Method Resolution Chain Position Source
AF-Q10N04-F1 Predicted AlphaFoldDB

No variants for Q10N04

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q10N04

No associated diseases with Q10N04

3 regional properties for Q10N04

Type Name Position InterPro Accession
domain NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal 71 - 121 IPR001516
domain NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit 137 - 418 IPR001750
domain NADH dehydrogenase subunit 5, C-terminal 425 - 604 IPR010934

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

1 GO annotations of molecular function

Name Definition
protein disulfide isomerase activity Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.

1 GO annotations of biological process

Name Definition
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KIL5 PDIA5 Protein disulfide-isomerase A5 Bos taurus (Bovine) PR
Q8N807 PDILT Protein disulfide-isomerase-like protein of the testis Homo sapiens (Human) PR
Q15084 PDIA6 Protein disulfide-isomerase A6 Homo sapiens (Human) PR
Q922R8 Pdia6 Protein disulfide-isomerase A6 Mus musculus (Mouse) PR
Q921X9 Pdia5 Protein disulfide-isomerase A5 Mus musculus (Mouse) PR
Q63081 Pdia6 Protein disulfide-isomerase A6 Rattus norvegicus (Rat) PR
Q5I0H9 Pdia5 Protein disulfide-isomerase A5 Rattus norvegicus (Rat) PR
Q67UF5 PDIL2-3 Protein disulfide isomerase-like 2-3 Oryza sativa subsp japonica (Rice) PR
Q9MAU6 PDIL2-2 Protein disulfide-isomerase like 2-2 Arabidopsis thaliana (Mouse-ear cress) PR
O48773 PDIL2-3 Protein disulfide-isomerase 2-3 Arabidopsis thaliana (Mouse-ear cress) PR
Q8GYD1 PDIL5-1 Protein disulfide-isomerase 5-1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MDLAPGRRAR LLVALALVVL VALAARSGAE VITLTEETFS DKIKEKDTVW FVKFCVPWCK
70 80 90 100 110 120
HCKNLGTLWE DLGKVMEGAD EIEIGQVDCG VSKPVCSKVD IHSYPTFKVF YEGEEVAKYK
130 140
GPRNVESLKN FVSDEAEKAG EAKLQDS