Q2KIL5
PR
Gene name |
PDIA5 |
Protein name |
Protein disulfide-isomerase A5 |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:511603 |
EC number |
5.3.4.1: Transposing S-S bonds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2KIL5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2KIL5-F1 | Predicted | AlphaFoldDB |
145 variants for Q2KIL5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs446006731 | 2 | A>G | No | EVA | |
| rs466050456 | 4 | V>G | No | EVA | |
| rs467503093 | 6 | P>R | No | EVA | |
| rs456281596 | 8 | W>G | No | EVA | |
| rs469881372 | 8 | W>L | No | EVA | |
| rs452122538 | 9 | L>P | No | EVA | |
| rs452122538 | 9 | L>R | No | EVA | |
| rs432090312 | 9 | L>V | No | EVA | |
| rs455198876 | 10 | L>P | No | EVA | |
| rs455198876 | 10 | L>R | No | EVA | |
| rs440851532 | 10 | L>V | No | EVA | |
| rs475323689 | 12 | P>A | No | EVA | |
| rs443803146 | 13 | L>P | No | EVA | |
| rs463951269 | 14 | A>G | No | EVA | |
| rs441054636 | 18 | V>A | No | EVA | |
| rs474772588 | 19 | L>P | No | EVA | |
| rs463435341 | 21 | T>P | No | EVA | |
| rs477128736 | 22 | W>C | No | EVA | |
| rs445578678 | 24 | S>P | No | EVA | |
| rs479456407 | 26 | A>E | No | EVA | |
| rs459306886 | 26 | A>T | No | EVA | |
| rs448736916 | 28 | F>S | No | EVA | |
| rs437339998 | 30 | S>L | No | EVA | |
| rs468718732 | 30 | S>P | No | EVA | |
| rs464487878 | 31 | L>P | No | EVA | |
| rs453348334 | 33 | E>D | No | EVA | |
| rs435607329 | 36 | S>F | No | EVA | |
| rs454788756 | 37 | D>N | No | EVA | |
| rs474936077 | 40 | D>E | No | EVA | |
| rs443424585 | 41 | L>F | No | EVA | |
| rs463599071 | 43 | K>R | No | EVA | |
| rs470780623 | 46 | R>T | No | EVA | |
| rs439239464 | 47 | T>A | No | EVA | |
| rs459400260 | 47 | T>I | No | EVA | |
| rs479425191 | 48 | R>L | No | EVA | |
| rs448025554 | 50 | N>S | No | EVA | |
| rs482369749 | 52 | L>R | No | EVA | |
| rs464555098 | 53 | V>G | No | EVA | |
| rs450990769 | 53 | V>M | No | EVA | |
| rs433378066 | 54 | L>F | No | EVA | |
| rs446915236 | 55 | Y>F | No | EVA | |
| rs467047908 | 57 | K>I | No | EVA | |
| rs467047908 | 57 | K>T | No | EVA | |
| rs435561883 | 58 | S>P | No | EVA | |
| rs435561883 | 58 | S>T | No | EVA | |
| rs439176319 | 69 | L>Q | No | EVA | |
| rs459139161 | 80 | G>S | No | EVA | |
| rs876631930 | 81 | T>P | No | EVA | |
| rs442248248 | 84 | W>G | No | EVA | |
| rs462297651 | 85 | V>G | No | EVA | |
| rs482454949 | 86 | D>H | No | EVA | |
| rs451021767 | 86 | D>V | No | EVA | |
| rs482454949 | 86 | D>Y | No | EVA | |
| rs464664262 | 88 | G>C | No | EVA | |
| rs383187988 | 90 | A>T | No | EVA | |
| rs456598424 | 116 | Q>L | No | EVA | |
| rs137631410 | 130 | F>V | No | EVA | |
| rs714114470 | 182 | P>L | No | EVA | |
| rs460266659 | 184 | C>G | No | EVA | |
| rs473779754 | 187 | C>F | No | EVA | |
| rs442492016 | 193 | H>P | No | EVA | |
| rs462549774 | 196 | K>N | No | EVA | |
| rs445548453 | 198 | A>S | No | EVA | |
| rs459060415 | 199 | T>A | No | EVA | |
| rs459060415 | 199 | T>P | No | EVA | |
| rs447688313 | 200 | Q>* | No | EVA | |
| rs467754615 | 201 | L>Q | No | EVA | |
| rs449955617 | 202 | R>L | No | EVA | |
| rs437856481 | 203 | G>A | No | EVA | |
| rs434108721 | 259 | K>E | No | EVA | |
| rs437679391 | 286 | E>D | No | EVA | |
| rs451457470 | 295 | H>P | No | EVA | |
| rs471390959 | 296 | S>P | No | EVA | |
| rs439987077 | 301 | M>I | No | EVA | |
| rs453655682 | 302 | F>S | No | EVA | |
| rs474489411 | 303 | H>P | No | EVA | |
| rs443120639 | 304 | A>P | No | EVA | |
| rs463141447 | 306 | W>G | No | EVA | |
| rs459301791 | 330 | S>G | No | EVA | |
| rs480089022 | 331 | S>P | No | EVA | |
| rs442379945 | 333 | V>A | No | EVA | |
| rs462337119 | 336 | A>V | No | EVA | |
| rs378944129 | 341 | V>I | No | EVA | |
| rs482464574 | 364 | E>D | No | EVA | |
| rs464629576 | 376 | S>G | No | EVA | |
| rs465868856 | 377 | F>V | No | EVA | |
| rs478370454 | 383 | N>D | No | EVA | |
| rs432931588 | 383 | N>K | No | EVA | |
| rs446809250 | 383 | N>S | No | EVA | |
| rs446675056 | 384 | P>A | No | EVA | |
| rs466639431 | 384 | P>R | No | EVA | |
| rs446675056 | 384 | P>T | No | EVA | |
| rs475444655 | 385 | E>A | No | EVA | |
| rs455309244 | 385 | E>Q | No | EVA | |
| rs438281500 | 386 | S>A | No | EVA | |
| rs472136780 | 388 | P>A | No | EVA | |
| rs454201148 | 389 | P>A | No | EVA | |
| rs474083881 | 389 | P>H | No | EVA | |
| rs442913275 | 390 | P>Q | No | EVA | |
| rs438793898 | 391 | D>A | No | EVA | |
| rs438793898 | 391 | D>G | No | EVA | |
| rs483142911 | 391 | D>N | No | EVA | |
| rs438793898 | 391 | D>V | No | EVA | |
| rs478165157 | 393 | A>P | No | EVA | |
| rs446635767 | 394 | W>R | No | EVA | |
| rs466800833 | 395 | E>A | No | EVA | |
| rs466800833 | 395 | E>G | No | EVA | |
| rs480301364 | 397 | Q>H | No | EVA | |
| rs449045042 | 399 | T>N | No | EVA | |
| rs449045042 | 399 | T>S | No | EVA | |
| rs469106631 | 401 | V>G | No | EVA | |
| rs437543367 | 402 | L>V | No | EVA | |
| rs434276921 | 406 | G>E | No | EVA | |
| rs454164325 | 408 | N>T | No | EVA | |
| rs798073534 | 410 | R>Q | No | EVA | |
| rs474249181 | 410 | R>W | No | EVA | |
| rs442878395 | 412 | T>S | No | EVA | |
| rs456429383 | 413 | L>P | No | EVA | |
| rs438751791 | 416 | K>Q | No | EVA | |
| rs458975052 | 417 | K>Q | No | EVA | |
| rs478136161 | 418 | H>P | No | EVA | |
| rs440372022 | 419 | A>S | No | EVA | |
| rs460328687 | 420 | L>F | No | EVA | |
| rs480366725 | 421 | V>G | No | EVA | |
| rs449108831 | 424 | Y>S | No | EVA | |
| rs517827471 | 441 | A>T | No | EVA | |
| rs464244648 | 452 | A>P | No | EVA | |
| rs432778322 | 454 | A>P | No | EVA | |
| rs446410060 | 458 | C>S | No | EVA | |
| rs467259035 | 461 | E>D | No | EVA | |
| rs435849480 | 465 | D>V | No | EVA | |
| rs455870053 | 467 | C>R | No | EVA | |
| rs476099040 | 468 | Q>P | No | EVA | |
| rs438151673 | 471 | A>S | No | EVA | |
| rs134930259 | 480 | Y>S | No | EVA | |
| rs471687706 | 482 | H>L | No | EVA | |
| rs471687706 | 482 | H>P | No | EVA | |
| rs451728393 | 482 | H>Y | No | EVA | |
| rs440387303 | 483 | Y>D | No | EVA | |
| rs460521341 | 489 | K>Q | No | EVA | |
| rs473294955 | 492 | T>P | No | EVA | |
| rs466991922 | 500 | T>I | No | EVA | |
| rs471653776 | 510 | D>E | No | EVA | |
| rs479006555 | 518 | K>N | No | EVA | |
| rs440212289 | 519 | E>G | No | EVA |
No associated diseases with Q2KIL5
8 regional properties for Q2KIL5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Thioredoxin domain | 136 - 263 | IPR013766-1 |
| domain | Thioredoxin domain | 274 - 386 | IPR013766-2 |
| domain | Thioredoxin domain | 387 - 508 | IPR013766-3 |
| conserved_site | Thioredoxin, conserved site | 299 - 317 | IPR017937 |
| domain | Protein disulfide-isomerase A5, N-terminal TRX-like b domain | 30 - 141 | IPR041865 |
| domain | Protein disulfide-isomerase A5, TRX (a) domain | 154 - 258 | IPR046374-1 |
| domain | Protein disulfide-isomerase A5, TRX (a) domain | 279 - 381 | IPR046374-2 |
| domain | Protein disulfide-isomerase A5, TRX (a) domain | 400 - 503 | IPR046374-3 |
Functions
| Description | ||
|---|---|---|
| EC Number | 5.3.4.1 | Transposing S-S bonds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum lumen | The volume enclosed by the membranes of the endoplasmic reticulum. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein disulfide isomerase activity | Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins. |
| protein-disulfide reductase activity | Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8N807 | PDILT | Protein disulfide-isomerase-like protein of the testis | Homo sapiens (Human) | PR |
| Q15084 | PDIA6 | Protein disulfide-isomerase A6 | Homo sapiens (Human) | PR |
| Q922R8 | Pdia6 | Protein disulfide-isomerase A6 | Mus musculus (Mouse) | PR |
| Q921X9 | Pdia5 | Protein disulfide-isomerase A5 | Mus musculus (Mouse) | PR |
| Q63081 | Pdia6 | Protein disulfide-isomerase A6 | Rattus norvegicus (Rat) | PR |
| Q5I0H9 | Pdia5 | Protein disulfide-isomerase A5 | Rattus norvegicus (Rat) | PR |
| Q67UF5 | PDIL2-3 | Protein disulfide isomerase-like 2-3 | Oryza sativa subsp japonica (Rice) | PR |
| Q10N04 | PDIL5-1 | Protein disulfide isomerase-like 5-1 | Oryza sativa subsp japonica (Rice) | PR |
| Q9MAU6 | PDIL2-2 | Protein disulfide-isomerase like 2-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O48773 | PDIL2-3 | Protein disulfide-isomerase 2-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8GYD1 | PDIL5-1 | Protein disulfide-isomerase 5-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARVVPAWLL | LPLAVWVVLP | TWLSSAKFSS | LIERISDPKD | LKKLLRTRNN | VLVLYSKSEA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AAESHLKLLS | TVAQAVKGQG | TICWVDCGDA | ESRKLCKKMK | VDLSAKDKKV | ELFHYQDGAF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HTEYNRAVTF | KSIVAFLKDP | KGPPLWEEDP | GAKDVVHIDN | EKDFRRLLKK | EEKPILMMFY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| APWCSVCKRI | MPHFQKAATQ | LRGQFVLAGM | NVYPSEFENI | KEEYSVRGYP | TICYFEKGRF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LFQYDSYGST | AEDIVEWLKN | PQPPQPQVPE | TPWADEGGSV | YHLSDEDFDQ | FVKEHSSVLV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MFHAPWCGHC | KKMKPEFESA | AEVLHGEGDS | SGVLAAVDAT | VNKALAERFH | IAEFPTLKYF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KNGEKYAVPA | LRTKKSFIEW | MRNPESPPPP | DPAWEEQQTS | VLHLSGDNFR | ETLKRKKHAL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VMFYAPWCPH | CKKAIPHFTA | AADAFKDDRK | IACAAIDCVK | ENNKDLCQQE | AVKAYPTFHY |
| 490 | 500 | 510 | 520 | ||
| YHYGKFVEKY | DTNPTELGFT | SFIRTLREGD | HERLGKKKEE | L |