Q8GYD1
Gene name |
PDIL5-1 (PDIL6-1, At1g07960, T6D22.5) |
Protein name |
Protein disulfide-isomerase 5-1 |
Names |
AtPDIL5-1, Protein disulfide-isomerase 6-1, AtPDIL6-1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G07960 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8GYD1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8GYD1-F1 | Predicted | AlphaFoldDB |
9 variants for Q8GYD1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH04537175 | 5 | A>G | No | 1000Genomes | |
| tmp_1_2467697_G_A | 6 | R>Q | No | 1000Genomes | |
| ENSVATH01023273 | 29 | T>I | No | 1000Genomes | |
| ENSVATH10762239 | 36 | S>T | No | 1000Genomes | |
| tmp_1_2468332_G_T | 48 | V>L | No | 1000Genomes | |
| ENSVATH04537184 | 74 | G>R | No | 1000Genomes | |
| ENSVATH10762309 | 98 | H>Y | No | 1000Genomes | |
| ENSVATH04537185 | 112 | V>I | No | 1000Genomes | |
| tmp_1_2468809_A_G | 140 | Q>R | No | 1000Genomes |
No associated diseases with Q8GYD1
1 regional properties for Q8GYD1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Thioredoxin domain | 3 - 133 | IPR013766 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein disulfide isomerase activity | Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2KIL5 | PDIA5 | Protein disulfide-isomerase A5 | Bos taurus (Bovine) | PR |
| Q8N807 | PDILT | Protein disulfide-isomerase-like protein of the testis | Homo sapiens (Human) | PR |
| Q15084 | PDIA6 | Protein disulfide-isomerase A6 | Homo sapiens (Human) | PR |
| Q922R8 | Pdia6 | Protein disulfide-isomerase A6 | Mus musculus (Mouse) | PR |
| Q921X9 | Pdia5 | Protein disulfide-isomerase A5 | Mus musculus (Mouse) | PR |
| Q63081 | Pdia6 | Protein disulfide-isomerase A6 | Rattus norvegicus (Rat) | PR |
| Q5I0H9 | Pdia5 | Protein disulfide-isomerase A5 | Rattus norvegicus (Rat) | PR |
| Q67UF5 | PDIL2-3 | Protein disulfide isomerase-like 2-3 | Oryza sativa subsp japonica (Rice) | PR |
| Q10N04 | PDIL5-1 | Protein disulfide isomerase-like 5-1 | Oryza sativa subsp japonica (Rice) | PR |
| Q9MAU6 | PDIL2-2 | Protein disulfide-isomerase like 2-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O48773 | PDIL2-3 | Protein disulfide-isomerase 2-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTLGARLVAP | MIILLLFIPI | ELVKAEVITL | TPETFSDKIK | EKDTAWFVKF | CVPWCKHCKK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LGNLWEDLGK | AMEGDDEIEV | GEVDCGTSRA | VCTKVEIHSY | PTFMLFYNGE | EVSKYKGKRD |
| 130 | 140 | ||||
| VESLKAFVVE | ETEKAAEKAQ | LEDKEL |