Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q9LW76

Entry ID Method Resolution Chain Position Source
AF-Q9LW76-F1 Predicted AlphaFoldDB

7 variants for Q9LW76

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH05841280 32 K>T No 1000Genomes
tmp_3_5459622_A_G 56 I>V No 1000Genomes
ENSVATH13928320 82 D>N No 1000Genomes
tmp_3_5460077_G_A 116 E>K No 1000Genomes
tmp_3_5460352_G_T 178 K>N No 1000Genomes
ENSVATH05841301 194 A>T No 1000Genomes
ENSVATH13928321 197 R>Q No 1000Genomes

No associated diseases with Q9LW76

1 regional properties for Q9LW76

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 10 - 172 IPR005225

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Lipid-anchor ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
vacuolar membrane The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

2 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

1 GO annotations of biological process

Name Definition
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P18067 RAB7A Ras-related protein Rab-7a Canis lupus familiaris (Dog) (Canis familiaris) PR
P51149 RAB7A Ras-related protein Rab-7a Homo sapiens (Human) PR
Q9NP90 RAB9B Ras-related protein Rab-9B Homo sapiens (Human) PR
P51150 Rab7a Ras-related protein Rab-7a Mus musculus (Mouse) PR
Q9R0M6 Rab9a Ras-related protein Rab-9A Mus musculus (Mouse) PR
P09527 Rab7a Ras-related protein Rab-7a Rattus norvegicus (Rat) PR
Q99P75 Rab9a Ras-related protein Rab-9A Rattus norvegicus (Rat) PR
Q9C820 RABG3D Ras-related protein RABG3d Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MASRRRVLLK VIILGDSGVG KTSLMNQFVN RKFSNQYKAT IGADFLTKEV QIDDRIFTLQ
70 80 90 100 110 120
IWDTAGQERF QSLGVAFYRG ADCCVLVNDV NVMKSFENLN NWREEFLIQA SPSDPENFPF
130 140 150 160 170 180
VVLGNKTDVD GGKSRVVTEK KAKSWCASKG NIPYFETSAK DGVNVDAAFE CIAKNALKNE
190 200
PEEEVYLPDT IDVAGARQQR STGCEC