Q9NP90
PR
Gene name |
RAB9B (RAB9L) |
Protein name |
Ras-related protein Rab-9B |
Names |
Rab-9-like protein, Rab-9L |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:51209 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q9NP90
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2OCB | X-ray | 220 A | A | 2-180 | PDB |
| AF-Q9NP90-F1 | Predicted | AlphaFoldDB |
69 variants for Q9NP90
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1484145278 CA414105944 |
10 | V>A | No |
ClinGen gnomAD |
|
|
CA414105953 rs1569435472 |
10 | V>F | No |
ClinGen Ensembl |
|
| TCGA novel | 19 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 25 | N>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs772724187 CA10479112 |
27 | Y>F | No |
ClinGen ExAC gnomAD |
|
|
rs1321964920 CA414105704 COSM456391 |
28 | V>I | Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
| TCGA novel | 29 | T>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1423771837 CA414105657 |
31 | K>N | No |
ClinGen TOPMed |
|
|
CA414105588 rs1309418405 |
36 | A>G | No |
ClinGen gnomAD |
|
|
rs1426691402 CA414105541 |
40 | I>V | No |
ClinGen gnomAD |
|
|
rs1375904490 CA414105443 |
47 | R>* | No |
ClinGen TOPMed gnomAD |
|
|
CA414105445 rs1375904490 |
47 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
rs372399381 CA10479109 |
47 | R>Q | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1483264654 CA414105436 |
48 | D>N | No |
ClinGen gnomAD |
|
|
rs770371462 CA10479108 |
49 | L>M | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 53 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10479107 rs746386881 |
54 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10479106 rs777348859 |
54 | R>H | No |
ClinGen ExAC |
|
|
rs1436117708 CA414105332 |
56 | V>L | No |
ClinGen gnomAD |
|
|
rs771123821 CA10479105 |
58 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs968207592 CA334004298 |
62 | D>G | No |
ClinGen Ensembl |
|
|
CA414105197 rs1344910465 |
66 | Q>* | No |
ClinGen gnomAD |
|
|
rs1221850245 CA414104755 |
84 | L>F | No |
ClinGen TOPMed |
|
|
CA10479101 rs747849601 |
86 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA10479099 rs181295698 |
89 | V>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1202532042 CA414104645 |
92 | R>Q | No |
ClinGen TOPMed |
|
|
CA414104646 rs1334219094 |
92 | R>W | No |
ClinGen gnomAD |
|
|
CA10479097 rs188884979 |
96 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA414104499 rs1472769494 |
99 | G>D | No |
ClinGen gnomAD |
|
|
rs990471942 CA334004297 |
104 | E>K | No |
ClinGen TOPMed |
|
|
rs1263222153 CA414104405 |
106 | I>V | No |
ClinGen TOPMed |
|
|
rs1411004945 CA414104344 |
109 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA414104289 rs1367306590 |
112 | K>R | No |
ClinGen gnomAD |
|
|
CA10479092 rs372221720 |
114 | P>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1441919665 CA414104217 |
116 | H>R | No |
ClinGen gnomAD |
|
|
rs765696707 CA10479091 |
116 | H>Y | No |
ClinGen ExAC |
|
|
CA10479090 rs760039495 |
118 | P>H | No |
ClinGen ExAC gnomAD |
|
|
rs182265761 CA334004295 |
121 | V>L | No |
ClinGen 1000Genomes |
|
|
CA10479088 rs771608148 |
123 | G>V | No |
ClinGen ExAC gnomAD |
|
|
CA10479086 rs773366134 |
131 | R>K | No |
ClinGen ExAC gnomAD |
|
|
CA414103950 rs1358421272 |
134 | T>A | No |
ClinGen TOPMed |
|
|
CA10479085 rs199858408 |
134 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 135 | T>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10479084 rs748406972 |
136 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1338218102 CA414103918 |
136 | E>V | No |
ClinGen gnomAD |
|
|
CA10479083 rs779172372 |
137 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs754752803 CA10479082 |
140 | T>A | No |
ClinGen ExAC |
|
|
CA334004294 rs1034798711 |
143 | M>T | No |
ClinGen TOPMed |
|
| TCGA novel | 146 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA414103720 rs1403175151 |
147 | D>G | No |
ClinGen TOPMed |
|
| TCGA novel | 148 | Y>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs749128249 CA10479081 |
148 | Y>F | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 149 | P>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10479080 rs779932850 |
152 | E>A | No |
ClinGen ExAC gnomAD |
|
|
CA334004293 rs926216691 |
155 | A>S | No |
ClinGen Ensembl |
|
| TCGA novel | 157 | D>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA334004292 rs978913807 |
158 | D>Y | No |
ClinGen Ensembl |
|
|
rs1416148426 CA414103527 |
159 | T>A | No |
ClinGen gnomAD |
|
|
CA414103501 rs1182675040 |
163 | V>M | No |
ClinGen gnomAD |
|
|
rs767064049 CA10479077 |
168 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA10479076 rs756788594 |
169 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA414103440 rs1278111672 |
172 | V>M | No |
ClinGen TOPMed |
|
|
COSM3424310 CA10479072 rs754287809 |
176 | E>D | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs761814878 CA10479070 |
181 | H>Q | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs368010774 CA10479069 |
191 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10479068 rs772188064 |
195 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs1602401762 CA414103120 |
197 | G>W | No |
ClinGen Ensembl |
|
|
CA10479067 rs761856500 |
199 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1266097474 CA414103051 |
202 | C>E | No |
ClinGen TOPMed |
No associated diseases with Q9NP90
1 regional properties for Q9NP90
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 9 - 166 | IPR005225 |
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| late endosome | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
| phagocytic vesicle | A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. |
| phagocytic vesicle membrane | The lipid bilayer surrounding a phagocytic vesicle. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| secretory granule membrane | The lipid bilayer surrounding a secretory granule. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| GDP binding | Binding to GDP, guanosine 5'-diphosphate. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| identical protein binding | Binding to an identical protein or proteins. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| Rab protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state. |
| retrograde transport, endosome to Golgi | The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P51149 | RAB7A | Ras-related protein Rab-7a | Homo sapiens (Human) | PR |
| P51150 | Rab7a | Ras-related protein Rab-7a | Mus musculus (Mouse) | PR |
| Q9R0M6 | Rab9a | Ras-related protein Rab-9A | Mus musculus (Mouse) | PR |
| P09527 | Rab7a | Ras-related protein Rab-7a | Rattus norvegicus (Rat) | PR |
| Q99P75 | Rab9a | Ras-related protein Rab-9A | Rattus norvegicus (Rat) | PR |
| Q9C820 | RABG3D | Ras-related protein RABG3d | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LW76 | RABG3C | Ras-related protein RABG3c | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGKSLLLKV | ILLGDGGVGK | SSLMNRYVTN | KFDSQAFHTI | GVEFLNRDLE | VDGRFVTLQI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WDTAGQERFK | SLRTPFYRGA | DCCLLTFSVD | DRQSFENLGN | WQKEFIYYAD | VKDPEHFPFV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VLGNKVDKED | RQVTTEEAQT | WCMENGDYPY | LETSAKDDTN | VTVAFEEAVR | QVLAVEEQLE |
| 190 | 200 | ||||
| HCMLGHTIDL | NSGSKAGSSC | C |