P18067
PR
Gene name |
RAB7A (RAB7) |
Protein name |
Ras-related protein Rab-7a |
Names |
|
Species |
Canis lupus familiaris (Dog) (Canis familiaris) |
KEGG Pathway |
cfa:404007 |
EC number |
3.6.5.2: Acting on GTP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P18067
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P18067-F1 | Predicted | AlphaFoldDB |
No variants for P18067
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P18067 | |||||
No associated diseases with P18067
1 regional properties for P18067
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 10 - 169 | IPR005225 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.5.2 | Acting on GTP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
14 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchored component of synaptic vesicle membrane | The component of the synaptic vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. |
| autophagosome membrane | The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| exocytic vesicle | A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. |
| extrinsic component of lysosome membrane | The component of an lysosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
| late endosome | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
| late endosome membrane | The lipid bilayer surrounding a late endosome. |
| lipid droplet | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
| melanosome membrane | The lipid bilayer surrounding a melanosome. |
| mitochondrial membrane | Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| phagocytic vesicle | A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. |
| phagocytic vesicle membrane | The lipid bilayer surrounding a phagocytic vesicle. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein activity | A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP). |
| GTP binding | Binding to GTP, guanosine triphosphate. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| early endosome to late endosome transport | The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs. |
| endosome to lysosome transport | The directed movement of substances from endosomes to lysosomes. |
| endosome to plasma membrane protein transport | The directed movement of proteins from the endosome to the plasma membrane in transport vesicles. |
| epidermal growth factor catabolic process | The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor. |
| lipid catabolic process | The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
| lipophagy | The selective autophagy process in which lipid droplets are delivered to the vacuole and degraded in response to changing cellular conditions. |
| phagosome acidification | Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion. |
| phagosome-lysosome fusion | The creation of a phagolysosome from a phagosome and a lysosome. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P51149 | RAB7A | Ras-related protein Rab-7a | Homo sapiens (Human) | PR |
| P51150 | Rab7a | Ras-related protein Rab-7a | Mus musculus (Mouse) | PR |
| P09527 | Rab7a | Ras-related protein Rab-7a | Rattus norvegicus (Rat) | PR |
| Q9LW76 | RABG3C | Ras-related protein RABG3c | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C820 | RABG3D | Ras-related protein RABG3d | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTSRKKVLLK | VIILGDSGVG | KTSLMNQYVN | KKFSNQYKAT | IGADFLTKEV | MVDDRLVTMQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IWDTAGQERF | QSLGVAFYRG | ADCCVLVFDV | TAPNTFKTLD | SWRDEFLIQA | SPRDPENFPF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VVLGNKIDLE | NRQVATKRAQ | AWCYSKNNIP | YFETSAKEAI | NVEQAFQTIA | RNALKQETEV |
| 190 | 200 | ||||
| ELYNEFPEPI | KLDKNDRAKT | SAESCSC |