Q9LU36

PR
Gene name
4CL4
Protein name
4-coumarate--CoA ligase 4
Names
4CL 4, (E)-ferulate--CoA ligase, 4-coumarate--CoA ligase isoform 5, At4CL5, 4-coumaroyl-CoA synthase 4, Sinapate--CoA ligase
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G21230
EC number
6.2.1.12: Acid--thiol ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9LU36

Entry ID Method Resolution Chain Position Source
AF-Q9LU36-F1 Predicted AlphaFoldDB

44 variants for Q9LU36

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_3_7451928_G_A 7 T>M No 1000Genomes
ENSVATH00337712 15 D>G No 1000Genomes
ENSVATH00337711 25 H>L No 1000Genomes
ENSVATH00337711 25 H>R No 1000Genomes
tmp_3_7451787_C_T 54 G>D No 1000Genomes
tmp_3_7451737_C_G 71 G>R No 1000Genomes
ENSVATH13958435 74 L>F No 1000Genomes
ENSVATH10822665 76 Y>F No 1000Genomes
ENSVATH05875942 76 Y>N No 1000Genomes
ENSVATH00337708 81 T>I No 1000Genomes
ENSVATH00337707 86 I>M No 1000Genomes
ENSVATH00337706 88 A>T No 1000Genomes
ENSVATH00337705 92 R>Q No 1000Genomes
tmp_3_7451578_C_T 124 V>I No 1000Genomes
ENSVATH05875940 148 M>I No 1000Genomes
tmp_3_7451466_T_G 161 N>T No 1000Genomes
ENSVATH05875938 167 V>A No 1000Genomes
ENSVATH02172583 171 C>S No 1000Genomes
ENSVATH00337700 180 V>I No 1000Genomes
ENSVATH00337699 183 S>L No 1000Genomes
ENSVATH05875937 184 S>I No 1000Genomes
ENSVATH05875937 184 S>T No 1000Genomes
ENSVATH00337698 185 D>G No 1000Genomes
ENSVATH10822622 197 A>G No 1000Genomes
ENSVATH02172582 203 L>P No 1000Genomes
ENSVATH13958414 205 P>H No 1000Genomes
tmp_3_7451335_G_A 205 P>S No 1000Genomes
ENSVATH10822621 206 K>E No 1000Genomes
tmp_3_7451325_G_A 208 S>L No 1000Genomes
ENSVATH10822617 283 A>V No 1000Genomes
ENSVATH05875935 288 P>L No 1000Genomes
tmp_3_7451049_T_G 300 Q>P No 1000Genomes
ENSVATH10822593 321 P>S No 1000Genomes
ENSVATH00337689 325 R>S No 1000Genomes
ENSVATH05875934 348 A>T No 1000Genomes
tmp_3_7450893_T_A 352 K>M No 1000Genomes
ENSVATH05875898 378 K>R No 1000Genomes
ENSVATH05875897 403 E>V No 1000Genomes
tmp_3_7448807_C_A 436 R>L No 1000Genomes
ENSVATH00337669 437 T>A No 1000Genomes
tmp_3_7448661_T_G 485 I>L No 1000Genomes
ENSVATH02172557 515 Q>E No 1000Genomes
ENSVATH13958394 537 R>Q No 1000Genomes
ENSVATH05875880 567 M>I No 1000Genomes

No associated diseases with Q9LU36

3 regional properties for Q9LU36

Type Name Position InterPro Accession
domain AMP-dependent synthetase/ligase domain 62 - 470 IPR000873
conserved_site AMP-binding, conserved site 215 - 226 IPR020845
domain AMP-binding enzyme, C-terminal domain 479 - 554 IPR025110

Functions

Description
EC Number 6.2.1.12 Acid--thiol ligases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
4-coumarate-CoA ligase activity Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
CoA-ligase activity Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA.

1 GO annotations of biological process

Name Definition
phenylpropanoid biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic derivatives of trans-cinnamic acid.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8VCW8 Acsf2 Medium-chain acyl-CoA ligase ACSF2, mitochondrial Mus musculus (Mouse) PR
P31685 4CL2 4-coumarate--CoA ligase 2 Solanum tuberosum (Potato) PR
P31684 4CL1 4-coumarate--CoA ligase 1 Solanum tuberosum (Potato) PR
Q8RU95 4CLL6 4-coumarate--CoA ligase-like 6 Oryza sativa subsp japonica (Rice) PR
Q10S72 4CLL4 4-coumarate--CoA ligase-like 4 Oryza sativa subsp japonica (Rice) PR
Q8H151 AAE13 Malonate--CoA ligase Arabidopsis thaliana (Mouse-ear cress) PR
Q84P24 4CLL6 4-coumarate--CoA ligase-like 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q84P26 4CLL8 4-coumarate--CoA ligase-like 8 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MVLQQQTHFL TKKIDQEDEE EEPSHDFIFR SKLPDIFIPN HLPLTDYVFQ RFSGDGDGDS
70 80 90 100 110 120
STTCIIDGAT GRILTYADVQ TNMRRIAAGI HRLGIRHGDV VMLLLPNSPE FALSFLAVAY
130 140 150 160 170 180
LGAVSTTANP FYTQPEIAKQ AKASAAKMII TKKCLVDKLT NLKNDGVLIV CLDDDGDNGV
190 200 210 220 230 240
VSSSDDGCVS FTELTQADET ELLKPKISPE DTVAMPYSSG TTGLPKGVMI THKGLVTSIA
250 260 270 280 290 300
QKVDGENPNL NFTANDVILC FLPMFHIYAL DALMLSAMRT GAALLIVPRF ELNLVMELIQ
310 320 330 340 350 360
RYKVTVVPVA PPVVLAFIKS PETERYDLSS VRIMLSGAAT LKKELEDAVR LKFPNAIFGQ
370 380 390 400 410 420
GYGMTESGTV AKSLAFAKNP FKTKSGACGT VIRNAEMKVV DTETGISLPR NKSGEICVRG
430 440 450 460 470 480
HQLMKGYLND PEATARTIDK DGWLHTGDIG FVDDDDEIFI VDRLKELIKF KGYQVAPAEL
490 500 510 520 530 540
EALLISHPSI DDAAVVAMKD EVADEVPVAF VARSQGSQLT EDDVKSYVNK QVVHYKRIKM
550 560
VFFIEVIPKA VSGKILRKDL RAKLETMCSK