Q8VCW8

PR
Gene name
Acsf2
Protein name
Medium-chain acyl-CoA ligase ACSF2, mitochondrial
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:264895
EC number
6.2.1.2: Acid--thiol ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-73 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8VCW8

Entry ID Method Resolution Chain Position Source
AF-Q8VCW8-F1 Predicted AlphaFoldDB

28 variants for Q8VCW8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs246806716 6 G>R No EVA
rs3389190512 17 S>I No EVA
rs3389207622 18 L>M No EVA
rs229375702 29 R>G No EVA
rs212696771 99 R>W No EVA
rs3389169299 170 V>I No EVA
rs252206392 171 G>A No EVA
rs3389202672 175 I>T No EVA
rs239423066 219 V>A No EVA
rs253745398 294 P>H No EVA
rs29438871 303 L>V No EVA
rs3389196759 305 L>M No EVA
rs3389162926 332 S>F No EVA
rs3389158388 338 G>D No EVA
rs3410333658 340 K>R No EVA
rs3389169217 341 A>E No EVA
rs3402751027 344 A>V No EVA
rs3389193033 357 P>S No EVA
rs3389193969 358 T>M No EVA
rs3389169301 414 S>T No EVA
rs3389190477 416 V>M No EVA
rs29387293 496 L>S No EVA
rs3389203686 542 G>E No EVA
rs242982171 546 E>K No EVA
rs3389155829 566 A>G No EVA
rs3389207698 567 E>G No EVA
rs3401981842 593 P>A No EVA
rs3402016874 595 T>P No EVA

No associated diseases with Q8VCW8

3 regional properties for Q8VCW8

Type Name Position InterPro Accession
domain AMP-dependent synthetase/ligase domain 79 - 515 IPR000873
conserved_site AMP-binding, conserved site 260 - 271 IPR020845
domain AMP-binding enzyme, C-terminal domain 524 - 599 IPR025110

Functions

Description
EC Number 6.2.1.2 Acid--thiol ligases
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
butyrate-CoA ligase activity Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA.
medium-chain fatty acid-CoA ligase activity Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a medium-chain fatty acid is any fatty acid with a chain length of between C6 and C12.

1 GO annotations of biological process

Name Definition
fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P31685 4CL2 4-coumarate--CoA ligase 2 Solanum tuberosum (Potato) PR
P31684 4CL1 4-coumarate--CoA ligase 1 Solanum tuberosum (Potato) PR
Q8RU95 4CLL6 4-coumarate--CoA ligase-like 6 Oryza sativa subsp japonica (Rice) PR
Q10S72 4CLL4 4-coumarate--CoA ligase-like 4 Oryza sativa subsp japonica (Rice) PR
Q9LU36 4CL4 4-coumarate--CoA ligase 4 Arabidopsis thaliana (Mouse-ear cress) PR
Q84P24 4CLL6 4-coumarate--CoA ligase-like 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q84P26 4CLL8 4-coumarate--CoA ligase-like 8 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAVYHGMLRF GRLCIASLGA RGPRTLLSRP RPNSKLQSVR ALSSGMVNCT NPLPIGGLSY
70 80 90 100 110 120
IQGHTDSHLV NTTVGECLDA TAQRFPDREA LVILHENIRL NFAQLKEEVD KAASGLLSIG
130 140 150 160 170 180
LRKGDRLGMW GPNSYAWVLI QLATAQAGII LVSVNPAYQS SELEYVLRKV GCKGIVFPKQ
190 200 210 220 230 240
FKTQQYYDIL KQVCPELEKA QPGALKSERL PDLTTVISVD APLPGTLLLD DIVAAGGKEQ
250 260 270 280 290 300
NLAQLRYNQR FLSCYDPINI QFTSGTTGNP KGATLSHHNI VNNSMLIGQR LKMPTKTAEE
310 320 330 340 350 360
LRLVLPSPLY HCLGSVGGTM VSMMHGATLL LSSPSFNGKK ALEAISREKG TLLYGTPTMF
370 380 390 400 410 420
VDILNQPDFS SYDFTSIRGG VIAGSPAPPE LIRAIINKMN MKELVVVYGT TENSPVTFMN
430 440 450 460 470 480
FPEDTLEQKA GSVGRIMPHT EAQIVNVETG ELTNLNVPGE LYIRGYCVMQ GYWGEPQKTF
490 500 510 520 530 540
ETVGQDKWYR TGDIALMDEQ GFCKIVGRSK DMIIRGGENI YPAELEDFFL KHPQVQEAQV
550 560 570 580 590 600
VGVKDERMGE EICACIRLKS GETTTAEEIK AFCKGKISHF KIPRYIVFVE GYPLTISGKI
610
QKFKLREQME QHLKL