Q8RU95

PR
Gene name
4CLL6 (Os01g0901600, LOC_Os01g67540, B1065G12.10, P0551C06.10)
Protein name
4-coumarate--CoA ligase-like 6
Names
Species
Oryza sativa subsp japonica (Rice)
KEGG Pathway
EC number
6.2.1.12: Acid--thiol ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8RU95

Entry ID Method Resolution Chain Position Source
AF-Q8RU95-F1 Predicted AlphaFoldDB

No variants for Q8RU95

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8RU95

No associated diseases with Q8RU95

2 regional properties for Q8RU95

Type Name Position InterPro Accession
domain Alpha crystallin/Hsp20 domain 78 - 185 IPR002068
domain Heat shock protein beta-8, alpha-crystallin domain (ACD) 80 - 170 IPR042790

Functions

Description
EC Number 6.2.1.12 Acid--thiol ligases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
4-coumarate-CoA ligase activity Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
CoA-ligase activity Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA.
trans-cinnamate-CoA ligase activity Catalysis of the reaction: (E)-cinnamate + ATP + CoA = (E)-cinnamoyl-CoA + AMP + diphosphate.

1 GO annotations of biological process

Name Definition
phenylpropanoid metabolic process The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8VCW8 Acsf2 Medium-chain acyl-CoA ligase ACSF2, mitochondrial Mus musculus (Mouse) PR
P31685 4CL2 4-coumarate--CoA ligase 2 Solanum tuberosum (Potato) PR
Q10S72 4CLL4 4-coumarate--CoA ligase-like 4 Oryza sativa subsp japonica (Rice) PR
Q8H151 AAE13 Malonate--CoA ligase Arabidopsis thaliana (Mouse-ear cress) PR
Q9LU36 4CL4 4-coumarate--CoA ligase 4 Arabidopsis thaliana (Mouse-ear cress) PR
Q84P24 4CLL6 4-coumarate--CoA ligase-like 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q84P26 4CLL8 4-coumarate--CoA ligase-like 8 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSKRSPPPQP AHIPMAEQRW RPPYPYASSA AGGGGVDRRS RSGFCAATRT FHSLRSVGPL
70 80 90 100 110 120
PPEELPLTVA AYAFSLLSSA PPLVVAGRGP ALVDAATGIA VSYPAFVARV RFLAGGLWCS
130 140 150 160 170 180
LGLRPGDVAL VVSPSCLDVA VLYFALMSIG VVVSPANPAS TADEYAHQVR LSRPAIAFVA
190 200 210 220 230 240
PEVAARLPRH VSRVVIGSEV FDRLASASAA GGWAAPPAVA MKQPSTAALL YSSGTTGRVK
250 260 270 280 290 300
AVAITHRNLI AQISAYNAIR ETVAREAATD AGKGKPPPPS PSPPAAVTLF PLPLFHVMGF
310 320 330 340 350 360
GLLTRTISSG ETAVVMRRFD LAAAARAVER YRVTKLSAAP PVVVALTKSD EARRRDLSSL
370 380 390 400 410 420
VAIVVGGAPL GREVSQRFAT VFPSVQIVQS YGLTESTGPV ATMAGPEESA AYGSVGRLAP
430 440 450 460 470 480
RVQAKIVDTA TGEVLGPGRR GELWIRGPVV MKGYVGDPEA TAATITPDGW LKTGDLCYFN
490 500 510 520 530 540
EDGYLYVVDR LKELIKYKGY QVPPAELEHI LQSRPEIADA AVVPYPDEEA GQLPMAFVVR
550 560 570 580 590
QPGAYLTEQQ VMNCVAKHVA PYKKVRRVAF VNAIPKSPAG KILRRELVLQ AMASTSRL