Q84P24

PR
Gene name
4CLL6
Protein name
4-coumarate--CoA ligase-like 6
Names
4-coumarate--CoA ligase, 4-coumarate--CoA ligase isoform 7, At4CL7, 4-hydroxybenzoate--CoA ligase
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G19010
EC number
6.2.1.12: Acid--thiol ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q84P24

Entry ID Method Resolution Chain Position Source
AF-Q84P24-F1 Predicted AlphaFoldDB

74 variants for Q84P24

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH02878367 12 P>A No 1000Genomes
ENSVATH02878366 12 P>H No 1000Genomes
ENSVATH02878365 14 T>I No 1000Genomes
ENSVATH02878364 15 Q>P No 1000Genomes
ENSVATH06721213 16 T>M No 1000Genomes
ENSVATH02878363 23 F>C No 1000Genomes
ENSVATH06721212 27 S>C No 1000Genomes
ENSVATH00521435 27 S>P No 1000Genomes
ENSVATH00521434 33 T>S No 1000Genomes
tmp_4_10414104_G_C 40 H>D No 1000Genomes
ENSVATH02878362 40 H>P No 1000Genomes
ENSVATH14251055 50 V>I No 1000Genomes
ENSVATH06721210 54 F>L No 1000Genomes
ENSVATH00521433 62 T>A No 1000Genomes
ENSVATH06721209 70 G>W No 1000Genomes
tmp_4_10414001_G_C 74 S>C No 1000Genomes
ENSVATH06721208 76 T>I No 1000Genomes
tmp_4_10413983_A_T 80 I>N No 1000Genomes
ENSVATH00521430 85 M>I No 1000Genomes
tmp_4_10413935_C_T 96 R>H No 1000Genomes
tmp_4_10413925_G_C 99 D>E No 1000Genomes
tmp_4_10413876_G_A 116 L>F No 1000Genomes
ENSVATH00521427 134 L>F No 1000Genomes
ENSVATH02878359 145 S>N No 1000Genomes
ENSVATH06721206 147 G>R No 1000Genomes
ENSVATH06721205 156 V>I No 1000Genomes
ENSVATH06721203 160 S>C No 1000Genomes
ENSVATH11998913 162 L>F No 1000Genomes
ENSVATH11998912 165 S>N No 1000Genomes
ENSVATH06721202 168 S>G No 1000Genomes
ENSVATH02878356 168 S>T No 1000Genomes
ENSVATH06721201 169 V>L No 1000Genomes
ENSVATH00521426 170 S>P No 1000Genomes
ENSVATH02878355 173 Y>H No 1000Genomes
tmp_4_10413682_G_C,A 180 I>M No 1000Genomes
ENSVATH06721200 181 E>K No 1000Genomes
tmp_4_10413675_G_A 183 P>S No 1000Genomes
ENSVATH11998911 184 K>N No 1000Genomes
ENSVATH06721199 186 Y>F No 1000Genomes
ENSVATH00521425 187 S>A No 1000Genomes
ENSVATH02878354 192 S>T No 1000Genomes
tmp_4_10413641_C_T 194 G>E No 1000Genomes
ENSVATH11998906 216 T>I No 1000Genomes
ENSVATH11998905 225 T>N No 1000Genomes
ENSVATH11998794 244 Y>F No 1000Genomes
tmp_4_10413462_G_C 254 L>V No 1000Genomes
ENSVATH00521421 283 K>R No 1000Genomes
ENSVATH06721196 287 A>T No 1000Genomes
tmp_4_10413362_G_A 287 A>V No 1000Genomes
ENSVATH02878349 310 M>V No 1000Genomes
ENSVATH02878348 311 A>V No 1000Genomes
tmp_4_10413195_C_T 343 E>K No 1000Genomes
ENSVATH06721195 352 V>A No 1000Genomes
tmp_4_10412914_T_C 361 T>A No 1000Genomes
tmp_4_10412899_C_T 366 V>I No 1000Genomes
tmp_4_10412879_G_T 372 N>K No 1000Genomes
ENSVATH02878342 373 S>L No 1000Genomes
ENSVATH06721189 379 Y>C No 1000Genomes
ENSVATH06721190 379 Y>N No 1000Genomes
ENSVATH14251021 380 S>P No 1000Genomes
tmp_4_10412854_A_G 381 S>P No 1000Genomes
tmp_4_10412839_C_T 386 A>T No 1000Genomes
tmp_4_10412804_G_T 397 S>R No 1000Genomes
tmp_4_10412796_G_A 400 S>F No 1000Genomes
ENSVATH06721187 412 I>L No 1000Genomes
tmp_4_10412448_A_C 422 L>V No 1000Genomes
ENSVATH06721176 455 V>I No 1000Genomes
tmp_4_10412317_T_A 465 K>N No 1000Genomes
tmp_4_10412206_C_T 477 V>I No 1000Genomes
tmp_4_10412200_C_T 479 V>I No 1000Genomes
ENSVATH14251015 485 I>L No 1000Genomes
tmp_4_10412175_G_A 487 A>V No 1000Genomes
tmp_4_10411814_T_G 534 K>N No 1000Genomes
ENSVATH00521406 539 N>H No 1000Genomes

No associated diseases with Q84P24

3 regional properties for Q84P24

Type Name Position InterPro Accession
domain AMP-dependent synthetase/ligase domain 56 - 464 IPR000873
conserved_site AMP-binding, conserved site 209 - 220 IPR020845
domain AMP-binding enzyme, C-terminal domain 474 - 548 IPR025110

Functions

Description
EC Number 6.2.1.12 Acid--thiol ligases
Subcellular Localization
  • Peroxisome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

5 GO annotations of molecular function

Name Definition
(E)-caffeate-CoA ligase activity Catalysis of the reaction: (E)-caffeate + ATP + CoA = (E)-caffeoyl-CoA + AMP + diphosphate.
4-coumarate-CoA ligase activity Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA.
4-hydroxybenzoate-CoA ligase activity Catalysis of the reaction: ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
CoA-ligase activity Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA.

1 GO annotations of biological process

Name Definition
ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8VCW8 Acsf2 Medium-chain acyl-CoA ligase ACSF2, mitochondrial Mus musculus (Mouse) PR
P31685 4CL2 4-coumarate--CoA ligase 2 Solanum tuberosum (Potato) PR
Q8RU95 4CLL6 4-coumarate--CoA ligase-like 6 Oryza sativa subsp japonica (Rice) PR
Q10S72 4CLL4 4-coumarate--CoA ligase-like 4 Oryza sativa subsp japonica (Rice) PR
Q8H151 AAE13 Malonate--CoA ligase Arabidopsis thaliana (Mouse-ear cress) PR
Q84P26 4CLL8 4-coumarate--CoA ligase-like 8 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LU36 4CL4 4-coumarate--CoA ligase 4 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAATHLHIPP NPKTQTSHQN PPFWFSSKTG IYTSKFPSLH LPVDPNLDAV SALFSHKHHG
70 80 90 100 110 120
DTALIDSLTG FSISHTELQI MVQSMAAGIY HVLGVRQGDV VSLVLPNSVY FPMIFLSLIS
130 140 150 160 170 180
LGAIVTTMNP SSSLGEIKKQ VSECSVGLAF TSTENVEKLS SLGVSVISVS ESYDFDSIRI
190 200 210 220 230 240
ENPKFYSIMK ESFGFVPKPL IKQDDVAAIM YSSGTTGASK GVLLTHRNLI ASMELFVRFE
250 260 270 280 290 300
ASQYEYPGSS NVYLAALPLC HIYGLSLFVM GLLSLGSTIV VMKRFDASDV VNVIERFKIT
310 320 330 340 350 360
HFPVVPPMLM ALTKKAKGVC GEVFKSLKQV SSGAAPLSRK FIEDFLQTLP HVDLIQGYGM
370 380 390 400 410 420
TESTAVGTRG FNSEKLSRYS SVGLLAPNMQ AKVVDWSSGS FLPPGNRGEL WIQGPGVMKG
430 440 450 460 470 480
YLNNPKATQM SIVEDSWLRT GDIAYFDEDG YLFIVDRIKE IIKYKGFQIA PADLEAVLVS
490 500 510 520 530 540
HPLIIDAAVT AAPNEECGEI PVAFVVRRQE TTLSEEDVIS YVASQVAPYR KVRKVVMVNS
550 560
IPKSPTGKIL RKELKRILTN SVSSRL