Q8H151
PR
Gene name |
AAE13 (At3g16170, MSL1.21) |
Protein name |
Malonate--CoA ligase |
Names |
Acyl-activating enzyme 13, Malonyl-CoA synthetase |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G16170 |
EC number |
6.2.1.76: Acid--thiol ligases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8H151
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8H151-F1 | Predicted | AlphaFoldDB |
54 variants for Q8H151
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH13928559 | 3 | A>G | No | 1000Genomes | |
| ENSVATH02150495 | 10 | F>L | No | 1000Genomes | |
| ENSVATH05841559 | 18 | H>N | No | 1000Genomes | |
| ENSVATH05841561 | 26 | A>T | No | 1000Genomes | |
| ENSVATH00326248 | 26 | A>V | No | 1000Genomes | |
| tmp_3_5476135_T_G | 28 | L>R | No | 1000Genomes | |
| ENSVATH05841562 | 35 | R>P | No | 1000Genomes | |
| ENSVATH02150497 | 44 | S>F | No | 1000Genomes | |
| tmp_3_5476189_C_T | 46 | S>F | No | 1000Genomes | |
| ENSVATH00326249 | 49 | R>Q | No | 1000Genomes | |
| tmp_3_5476207_A_T | 52 | Q>L | No | 1000Genomes | |
| tmp_3_5476216_A_G | 55 | H>R | No | 1000Genomes | |
| ENSVATH05841566 | 64 | L>F | No | 1000Genomes | |
| ENSVATH05841567 | 78 | S>F | No | 1000Genomes | |
| tmp_3_5476618_C_A | 107 | F>L | No | 1000Genomes | |
| ENSVATH00326256 | 108 | L>S | No | 1000Genomes | |
| ENSVATH05841570 | 113 | T>I | No | 1000Genomes | |
| tmp_3_5476781_G_C | 124 | G>A | No | 1000Genomes | |
| ENSVATH10710872 | 133 | I>V | No | 1000Genomes | |
| ENSVATH10710873 | 138 | K>I | No | 1000Genomes | |
| tmp_3_5476928_T_C | 173 | M>T | No | 1000Genomes | |
| ENSVATH13928561 | 181 | L>I | No | 1000Genomes | |
| ENSVATH13928561 | 181 | L>V | No | 1000Genomes | |
| ENSVATH10710930 | 192 | K>E | No | 1000Genomes | |
| tmp_3_5477322_G_C | 197 | K>N | No | 1000Genomes | |
| ENSVATH05841580 | 204 | L>P | No | 1000Genomes | |
| ENSVATH05841581 | 205 | I>T | No | 1000Genomes | |
| ENSVATH05841582 | 212 | T>I | No | 1000Genomes | |
| ENSVATH13928562 | 217 | A>P | No | 1000Genomes | |
| ENSVATH02150516 | 219 | N>T | No | 1000Genomes | |
| tmp_3_5477393_T_G | 221 | F>C | No | 1000Genomes | |
| tmp_3_5477397_G_C | 222 | Q>H | No | 1000Genomes | |
| tmp_3_5477404_A_C | 225 | S>R | No | 1000Genomes | |
| ENSVATH02150517 | 233 | L>I | No | 1000Genomes | |
| tmp_3_5477772_A_G | 264 | R>G | No | 1000Genomes | |
| ENSVATH00326267 | 268 | E>K | No | 1000Genomes | |
| ENSVATH10710932 | 284 | L>V | No | 1000Genomes | |
| ENSVATH00326268 | 301 | R>W | No | 1000Genomes | |
| tmp_3_5477887_C_G | 302 | S>C | No | 1000Genomes | |
| ENSVATH10710933 | 317 | R>C | No | 1000Genomes | |
| ENSVATH10710934 | 330 | T>A | No | 1000Genomes | |
| tmp_3_5478083_C_G | 330 | T>S | No | 1000Genomes | |
| tmp_3_5478100_G_A | 336 | V>I | No | 1000Genomes | |
| ENSVATH05841587 | 338 | T>S | No | 1000Genomes | |
| tmp_3_5478548_A_C | 356 | K>N | No | 1000Genomes | |
| tmp_3_5478754_G_A | 381 | R>Q | No | 1000Genomes | |
| tmp_3_5478951_G_A | 407 | A>T | No | 1000Genomes | |
| ENSVATH13928605 | 408 | M>I | No | 1000Genomes | |
| ENSVATH05841602 | 416 | R>Q | No | 1000Genomes | |
| ENSVATH00326279 | 417 | N>K | No | 1000Genomes | |
| ENSVATH05841605 | 469 | E>K | No | 1000Genomes | |
| tmp_3_5479774_G_C | 562 | E>Q | No | 1000Genomes | |
| tmp_3_5480121_A_G | 607 | Q>R | No | 1000Genomes | |
| ENSVATH10711025 | 608 | E>Q | No | 1000Genomes |
No associated diseases with Q8H151
Functions
| Description | ||
|---|---|---|
| EC Number | 6.2.1.76 | Acid--thiol ligases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| malonyl-CoA synthetase activity | Catalysis of the reaction: malonate + ATP + coenzyme A = malonyl-CoA + AMP + diphosphate. |
| medium-chain fatty acid-CoA ligase activity | Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a medium-chain fatty acid is any fatty acid with a chain length of between C6 and C12. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| fatty acid biosynthetic process | The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. |
| fatty acid metabolic process | The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. |
| malonate catabolic process | The chemical reactions and pathways resulting in the breakdown of malonate, the propanedioate ion. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P31685 | 4CL2 | 4-coumarate--CoA ligase 2 | Solanum tuberosum (Potato) | PR |
| Q8RU95 | 4CLL6 | 4-coumarate--CoA ligase-like 6 | Oryza sativa subsp japonica (Rice) | PR |
| Q10S72 | 4CLL4 | 4-coumarate--CoA ligase-like 4 | Oryza sativa subsp japonica (Rice) | PR |
| Q9LU36 | 4CL4 | 4-coumarate--CoA ligase 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84P24 | 4CLL6 | 4-coumarate--CoA ligase-like 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84P26 | 4CLL8 | 4-coumarate--CoA ligase-like 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTATTTLKSF | NYLSLINHRL | NHNSYAILSS | PLLPRSHPAS | TSFSNSGFRF | FQSNHLFSSQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SGSLMEVFKA | AFSEASNSCD | RIAIKADGKS | YSYGQLTSSA | LRISKLFLKD | DTTNGGQETK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KYEGFGSLKG | ARIGIVAKPS | AEFVAGVLGT | WFSGGVAVPL | ALSYPEAELL | HVMNDSDISL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LLSTEDHSET | MKTIAAKSGA | RFHLIPPVVN | STSETVACNQ | FQDDSFEAEG | KFLDDPALIV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YTSGTTGKPK | GVVHTHNSIN | SQVRMLTEAW | EYTSADHFLH | CLPLHHVHGL | FNALFAPLYA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RSLVEFLPKF | SVSGIWRRWR | ESYPVNDEKT | NDSITVFTGV | PTMYTRLIQG | YEAMDKEMQD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SSAFAARKLR | LMMSGSSALP | RPVMHQWESI | TGHRLLERYG | MTEFVMAMSN | PLRGARNAGT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VGKPLPGVEA | KIKEDENDAN | GVGEICVKSP | SLFKEYWNLP | EVTKESFTED | GYFKTGDAGR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VDEDGYYVIL | GRNSADIMKV | GGYKLSALEI | ESTLLEHPTV | AECCVLGLTD | NDYGEAVTAI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IIAESAAKKR | REDESKPVIT | LEELCGWAKD | KLAPYKLPTR | LLIWESLPRN | AMGKVNKKEL |
| KKSLENQE |