Q10S72

PR
Gene name
4CLL4 (Os03g0132000, LOC_Os03g04000, OsJ_09299)
Protein name
4-coumarate--CoA ligase-like 4
Names
Species
Oryza sativa subsp japonica (Rice)
KEGG Pathway
osa:4331515
EC number
6.2.1.12: Acid--thiol ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q10S72

Entry ID Method Resolution Chain Position Source
AF-Q10S72-F1 Predicted AlphaFoldDB

No variants for Q10S72

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q10S72

No associated diseases with Q10S72

3 regional properties for Q10S72

Type Name Position InterPro Accession
domain AMP-dependent synthetase/ligase domain 46 - 454 IPR000873
conserved_site AMP-binding, conserved site 204 - 215 IPR020845
domain AMP-binding enzyme, C-terminal domain 463 - 538 IPR025110

Functions

Description
EC Number 6.2.1.12 Acid--thiol ligases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

4 GO annotations of molecular function

Name Definition
4-coumarate-CoA ligase activity Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
CoA-ligase activity Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA.
trans-cinnamate-CoA ligase activity Catalysis of the reaction: (E)-cinnamate + ATP + CoA = (E)-cinnamoyl-CoA + AMP + diphosphate.

1 GO annotations of biological process

Name Definition
phenylpropanoid metabolic process The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8VCW8 Acsf2 Medium-chain acyl-CoA ligase ACSF2, mitochondrial Mus musculus (Mouse) PR
P31685 4CL2 4-coumarate--CoA ligase 2 Solanum tuberosum (Potato) PR
Q8RU95 4CLL6 4-coumarate--CoA ligase-like 6 Oryza sativa subsp japonica (Rice) PR
Q8H151 AAE13 Malonate--CoA ligase Arabidopsis thaliana (Mouse-ear cress) PR
Q9LU36 4CL4 4-coumarate--CoA ligase 4 Arabidopsis thaliana (Mouse-ear cress) PR
Q84P24 4CLL6 4-coumarate--CoA ligase-like 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q84P26 4CLL8 4-coumarate--CoA ligase-like 8 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGRSPEMEVD ARSGYCAATR TFRSRRADVP LPADPEVDVV SFLASRRHSG VVALVDAATG
70 80 90 100 110 120
RRITFTELWR AVAGAASALA AHPVSLRKGH VALILSPNSV HFPVAALAAM SLGAVLTTAN
130 140 150 160 170 180
PLNTPAEIAK QVADARPVLA FTTRELLPKL PRAHDLRVVL LESARLPGDS SDPRIVATIE
190 200 210 220 230 240
EISATTPDPA RRKDRVTQDD PATLLYSSGT TGPSKGVVAT HRSLISMVQI IMTRFRLEGS
250 260 270 280 290 300
DKTETFLCTV PMFHVYGLVA FATGLLGCGA TVVVLSKYEL PEMLRSINAY GVTYLPLVPP
310 320 330 340 350 360
ILVAMVAHPK PLPLGQMRKV LSGGAPLGKE LIEGFREKYP QVEILQGYGL TESTAIGAST
370 380 390 400 410 420
DSAEESRRYG TAGLLSPNTE AKIVDPDSGE ALPVNRTGEL WIRGPYVMKG YFKNAEATQS
430 440 450 460 470 480
TLTPDGWLKT GDLCYIDEDG YLFVVDRLKE LIKYKGYQVP PAELEALLLT HPEVTDVAVI
490 500 510 520 530 540
PFPDREVGQF PMAYIVRKKG SNLSEREVME FVAKQVAPYK KVRKVAFVTD IPKNASGKIL
550
RKDLIKLATS KL