Q84P26

PR
Gene name
4CLL8
Protein name
4-coumarate--CoA ligase-like 8
Names
4-coumarate--CoA ligase isoform 11, At4CL11
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G38120
EC number
6.2.1.12: Acid--thiol ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q84P26

Entry ID Method Resolution Chain Position Source
AF-Q84P26-F1 Predicted AlphaFoldDB

98 variants for Q84P26

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH07250179 2 A>V No 1000Genomes
tmp_5_15213797_T_A 9 S>T No 1000Genomes
tmp_5_15213803_A_G 11 I>V No 1000Genomes
tmp_5_15213819_G_T 16 G>V No 1000Genomes
ENSVATH07250181 19 T>P No 1000Genomes
ENSVATH03275525 20 S>L No 1000Genomes
ENSVATH12149239 23 T>S No 1000Genomes
ENSVATH03275526 32 A>V No 1000Genomes
ENSVATH07250184 33 L>V No 1000Genomes
ENSVATH00683850 36 K>N No 1000Genomes
ENSVATH07250185 39 L>F No 1000Genomes
tmp_5_15213890_G_A 40 D>N No 1000Genomes
tmp_5_15213899_A_G 43 T>A No 1000Genomes
ENSVATH00683851 50 Y>H No 1000Genomes
ENSVATH00683852 58 D>E No 1000Genomes
ENSVATH03275527 72 M>I No 1000Genomes
ENSVATH00683854 72 M>K No 1000Genomes
ENSVATH00683854 72 M>R No 1000Genomes
ENSVATH07250187 76 R>H No 1000Genomes
ENSVATH12149241 77 V>L No 1000Genomes
ENSVATH00683855 82 L>V No 1000Genomes
ENSVATH03275528 88 R>W No 1000Genomes
tmp_5_15214053_T_A 94 L>Q No 1000Genomes
ENSVATH12149242 95 V>L No 1000Genomes
ENSVATH03275531 102 S>Y No 1000Genomes
ENSVATH03275532 106 V>I No 1000Genomes
tmp_5_15214112_G_C 114 G>R No 1000Genomes
tmp_5_15214121_T_G 117 L>V No 1000Genomes
ENSVATH12149243 120 A>G No 1000Genomes
ENSVATH07250188 122 P>L No 1000Genomes
tmp_5_15214148_G_C 126 A>P No 1000Genomes
tmp_5_15214157_A_C 129 I>L No 1000Genomes
ENSVATH12149244 134 A>G No 1000Genomes
tmp_5_15214199_A_G 143 T>A No 1000Genomes
tmp_5_15214218_C_A 149 P>H No 1000Genomes
ENSVATH14537938 152 A>V No 1000Genomes
ENSVATH07250191 156 I>V No 1000Genomes
ENSVATH07250192 158 I>T No 1000Genomes
tmp_5_15214259_G_A 163 V>I No 1000Genomes
tmp_5_15214267_C_A 165 D>E No 1000Genomes
ENSVATH07250193 166 T>I No 1000Genomes
ENSVATH07250194 168 R>C No 1000Genomes
ENSVATH03275533 169 V>A No 1000Genomes
ENSVATH07250195 177 G>R No 1000Genomes
tmp_5_15214337_G_A 189 G>R No 1000Genomes
ENSVATH07250196 193 R>K No 1000Genomes
ENSVATH07250197 198 K>N No 1000Genomes
tmp_5_15214374_C_G 201 T>R No 1000Genomes
ENSVATH07250198 221 H>Q No 1000Genomes
tmp_5_15214437_G_T 222 G>V No 1000Genomes
ENSVATH00683861 229 A>S No 1000Genomes
ENSVATH00683862 229 A>V No 1000Genomes
ENSVATH00683863 233 A>T No 1000Genomes
ENSVATH07250199 239 P>A No 1000Genomes
ENSVATH14537941 263 L>* No 1000Genomes
ENSVATH07250201 278 G>E No 1000Genomes
ENSVATH00683868 281 M>L No 1000Genomes
tmp_5_15214622_G_T 284 V>F No 1000Genomes
ENSVATH07250203 287 Y>C No 1000Genomes
ENSVATH03275541 298 V>D No 1000Genomes
ENSVATH12149297 304 N>D No 1000Genomes
tmp_5_15214697_A_C 309 I>L No 1000Genomes
ENSVATH07250205 316 S>G No 1000Genomes
tmp_5_15214752_C_T 327 P>L No 1000Genomes
ENSVATH00683869 334 Q>E No 1000Genomes
ENSVATH14537942 337 M>L No 1000Genomes
ENSVATH03275543 338 K>N No 1000Genomes
ENSVATH07250208 341 P>S No 1000Genomes
ENSVATH03275544 342 T>M No 1000Genomes
ENSVATH00683870 350 A>P No 1000Genomes
ENSVATH00683871 361 I>V No 1000Genomes
tmp_5_15214875_G_T 368 R>L No 1000Genomes
tmp_5_15214915_A_C 381 E>D No 1000Genomes
ENSVATH07250210 381 E>K No 1000Genomes
ENSVATH07250211 382 A>E No 1000Genomes
ENSVATH03275546 391 Q>R No 1000Genomes
ENSVATH07250212 396 N>S No 1000Genomes
ENSVATH03275547 397 Q>L No 1000Genomes
ENSVATH00683873 410 K>N No 1000Genomes
ENSVATH03275567 421 T>N No 1000Genomes
ENSVATH07250229 427 K>R No 1000Genomes
ENSVATH07250230 433 Y>F No 1000Genomes
ENSVATH00683876 436 N>D No 1000Genomes
ENSVATH07250231 440 L>I No 1000Genomes
tmp_5_15215510_C_G 449 L>V No 1000Genomes
ENSVATH07250238 461 E>Q No 1000Genomes
tmp_5_15215661_C_G 465 L>V No 1000Genomes
ENSVATH07250239 467 L>Q No 1000Genomes
ENSVATH12149523 487 Q>E No 1000Genomes
tmp_5_15215881_C_T 497 P>S No 1000Genomes
ENSVATH03275587 504 K>E No 1000Genomes
tmp_5_15215907_G_T 505 K>N No 1000Genomes
ENSVATH12149599 524 A>T No 1000Genomes
ENSVATH07250254 546 A>S No 1000Genomes
tmp_5_15216124_T_A 547 I>N No 1000Genomes
ENSVATH12149600 549 K>N No 1000Genomes
ENSVATH03275595 550 I>F No 1000Genomes
tmp_5_15216136_A_T 551 I>L No 1000Genomes

No associated diseases with Q84P26

3 regional properties for Q84P26

Type Name Position InterPro Accession
domain AMP-dependent synthetase/ligase domain 47 - 452 IPR000873
conserved_site AMP-binding, conserved site 204 - 215 IPR020845
domain AMP-binding enzyme, C-terminal domain 461 - 536 IPR025110

Functions

Description
EC Number 6.2.1.12 Acid--thiol ligases
Subcellular Localization
  • Peroxisome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
CoA-ligase activity Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA.

1 GO annotations of biological process

Name Definition
ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8VCW8 Acsf2 Medium-chain acyl-CoA ligase ACSF2, mitochondrial Mus musculus (Mouse) PR
P31685 4CL2 4-coumarate--CoA ligase 2 Solanum tuberosum (Potato) PR
Q8RU95 4CLL6 4-coumarate--CoA ligase-like 6 Oryza sativa subsp japonica (Rice) PR
Q10S72 4CLL4 4-coumarate--CoA ligase-like 4 Oryza sativa subsp japonica (Rice) PR
Q8H151 AAE13 Malonate--CoA ligase Arabidopsis thaliana (Mouse-ear cress) PR
Q84P24 4CLL6 4-coumarate--CoA ligase-like 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LU36 4CL4 4-coumarate--CoA ligase 4 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MANSQRSSSL IDPRNGFCTS NSTFYSKRKP LALPSKESLD ITTFISSQTY RGKTAFIDAA
70 80 90 100 110 120
TDHRISFSDL WMAVDRVADC LLHDVGIRRG DVVLVLSPNT ISIPIVCLSV MSLGAVLTTA
130 140 150 160 170 180
NPLNTASEIL RQIADSNPKL AFTTPELAPK IASSGISIVL ERVEDTLRVP RGLKVVGNLT
190 200 210 220 230 240
EMMKKEPSGQ AVRNQVHKDD TAMLLYSSGT TGRSKGVNSS HGNLIAHVAR YIAEPFEQPQ
250 260 270 280 290 300
QTFICTVPLF HTFGLLNFVL ATLALGTTVV ILPRFDLGEM MAAVEKYRAT TLILVPPVLV
310 320 330 340 350 360
TMINKADQIM KKYDVSFLRT VRCGGAPLSK EVTQGFMKKY PTVDVYQGYA LTESNGAGAS
370 380 390 400 410 420
IESVEESRRY GAVGLLSCGV EARIVDPNTG QVMGLNQTGE LWLKGPSIAK GYFRNEEEII
430 440 450 460 470 480
TSEGWLKTGD LCYIDNDGFL FIVDRLKELI KYKGYQVPPA ELEALLLNHP DILDAAVIPF
490 500 510 520 530 540
PDKEAGQFPM AYVARKPESN LCEKKVIDFI SKQVAPYKKI RKVAFIDSIP KTPSGKTLRK
DLIKFAISKI