Q9JMD2
PR
Gene name |
Sfmbt1 |
Protein name |
Scm-like with four MBT domains protein 1 |
Names |
|
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:58967 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9JMD2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JMD2-F1 | Predicted | AlphaFoldDB |
2 variants for Q9JMD2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs8155280 | 195 | Q>H | No | EVA | |
| rs8165820 | 838 | L>I | No | EVA |
No associated diseases with Q9JMD2
9 regional properties for Q9JMD2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Sterile alpha motif domain | 790 - 856 | IPR001660 |
| repeat | Mbt repeat | 20 - 123 | IPR004092-1 |
| repeat | Mbt repeat | 128 - 235 | IPR004092-2 |
| repeat | Mbt repeat | 242 - 349 | IPR004092-3 |
| repeat | Mbt repeat | 354 - 453 | IPR004092-4 |
| domain | SLED domain | 499 - 613 | IPR021987 |
| domain | Scm-like with four MBT domains protein 1/2, SAM domain | 779 - 863 | IPR037604 |
| repeat | Scm-like with four MBT domains protein 1, third MBT repeat | 271 - 364 | IPR047351 |
| repeat | Scm-like with four MBT domains protein 1, second MBT repeat | 159 - 255 | IPR047352 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
| transcription corepressor activity | A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| chromatin organization | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| negative regulation of muscle organ development | Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q969R5 | L3MBTL2 | Lethal(3)malignant brain tumor-like protein 2 | Homo sapiens (Human) | PR |
| Q9UQR0 | SCML2 | Sex comb on midleg-like protein 2 | Homo sapiens (Human) | PR |
| Q96GD3 | SCMH1 | Polycomb protein SCMH1 | Homo sapiens (Human) | PR |
| Q9Y468 | L3MBTL1 | Lethal(3)malignant brain tumor-like protein 1 | Homo sapiens (Human) | PR |
| Q96JM7 | L3MBTL3 | Lethal(3)malignant brain tumor-like protein 3 | Homo sapiens (Human) | PR |
| Q9UHJ3 | SFMBT1 | Scm-like with four MBT domains protein 1 | Homo sapiens (Human) | PR |
| Q8BLB7 | L3mbtl3 | Lethal(3)malignant brain tumor-like protein 3 | Mus musculus (Mouse) | PR |
| A2A5N8 | L3mbtl1 | Lethal(3)malignant brain tumor-like protein 1 | Mus musculus (Mouse) | PR |
| Q9JMD1 | Sfmbt1 | Scm-like with four MBT domains protein 1 | Mus musculus (Mouse) | PR |
| B2D6M2 | lin-61 | Protein lin-61 | Caenorhabditis elegans | PR |
| Q11193 | sor-3 | Sop-2-related protein 3 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNGEQQLDAD | LGSGVEVEEF | SWEDYLEETG | ATTAPYASFK | HVDICLQSGF | APGMKLEVAL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RKDPETYWVA | TVITACEQLL | LLRYEGYGED | RKADFWCDIR | RAGLYPIGWC | QQNKKTLEAP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EGIRDKVSDW | SAFLQRTLTG | ACGPPVALLE | GLRNGRNPLD | LIAPGSRLEC | QDFRDSVSTW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IVTVVENIGG | RLKLQYEGLE | RHDGFEHWLY | YLDPFLHHIG | WAAQQGYELQ | PPLAIRHLKN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EADWQEILAR | VKEEEPLPSY | LFKDKQVIRT | HEFSINMKLE | AVDPWSPFGI | SPATIAKVFD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DKYFLVEIDD | LRPEDHARRS | FVCHANSPGI | FPVQWSLKNG | LHINPPPGFR | SQDFDWADYL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KQCGAEAAPQ | KCFPQSVSEH | QFKENMKLEA | VNPLFPEEVS | IATVTAVRGS | YLWLQLEGSK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KPVPEFIVSV | ESMNIFPLGW | CETNGHPLST | PRRARGHKLR | KIAVVQPEKQ | ILSSRTVHEG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LKNQLNSPHS | VMINGKYCCP | KIYFNHRCFS | GPYLNKGRIA | ELPQCVGPGN | CVLVLREVLT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LLINAAYKPS | RVLRELQLDK | DSVWHGCGEV | LKAKYKGKSY | RATVEIVRTA | DRVTEFCRQT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| CIKLECCPNL | FGPRMVLDTC | SENCSVLTKT | KYTHYYGKKK | NKRIGRPPGG | HSNLSCALKK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TSKRRKRRKN | IFVHKKKRSS | ASVDNTPVGS | PQGSGGEDED | DADDGDDDSL | TEGSTSEQQD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ELHEESEVSE | KKSCSPSPTQ | SEMSTPLPPD | TQTDKREAQT | SSLSDGENKP | PSPKEIRIEV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DERLHLDSNP | LKWSVADVVR | FIRSTDCAPL | ARIFLDQEID | GQALLLLTLP | TVQECMDLKL |
| 850 | 860 | ||||
| GPAIKLCHHI | ERIKFAFYEQ | FAN |