B2D6M2

PR
Gene name
lin-61 (R06C7.7)
Protein name
Protein lin-61
Names
Abnormal cell lineage protein 61
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_R06C7.7
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

369-438 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B2D6M2

Entry ID Method Resolution Chain Position Source
AF-B2D6M2-F1 Predicted AlphaFoldDB

No variants for B2D6M2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B2D6M2

No associated diseases with B2D6M2

No regional properties for B2D6M2

Type Name Position InterPro Accession
No domain, repeats, and functional sites for B2D6M2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.

2 GO annotations of biological process

Name Definition
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
vulval development The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UQR0 SCML2 Sex comb on midleg-like protein 2 Homo sapiens (Human) PR
Q96GD3 SCMH1 Polycomb protein SCMH1 Homo sapiens (Human) PR
Q9UHJ3 SFMBT1 Scm-like with four MBT domains protein 1 Homo sapiens (Human) PR
Q9Y468 L3MBTL1 Lethal(3)malignant brain tumor-like protein 1 Homo sapiens (Human) PR
Q96JM7 L3MBTL3 Lethal(3)malignant brain tumor-like protein 3 Homo sapiens (Human) PR
Q969R5 L3MBTL2 Lethal(3)malignant brain tumor-like protein 2 Homo sapiens (Human) PR
Q8BLB7 L3mbtl3 Lethal(3)malignant brain tumor-like protein 3 Mus musculus (Mouse) PR
A2A5N8 L3mbtl1 Lethal(3)malignant brain tumor-like protein 1 Mus musculus (Mouse) PR
Q9JMD1 Sfmbt1 Scm-like with four MBT domains protein 1 Mus musculus (Mouse) PR
Q9JMD2 Sfmbt1 Scm-like with four MBT domains protein 1 Rattus norvegicus (Rat) PR
Q11193 sor-3 Sop-2-related protein 3 Caenorhabditis elegans PR
10 20 30 40 50 60
MLKLVILCFA LFYNTVSSTR FLFGVEVKCD FDEVFQLTVS HWEDDGNTFW DRDEDITGRM
70 80 90 100 110 120
TMFARKKIFF YQDGHHGFEF GKLEPYGWFL HNCTKNGNFR EYRHGLSSTS GSNGLEYIEY
130 140 150 160 170 180
TMSEFLKIVR ANKKSDRKLD KTYLWESYLH QFEKGKTSFI PVEAFNRNLT VNFNECVKEG
190 200 210 220 230 240
VIFETVVHDY DKNCDSIQVR WFARIEKVCG YRVLAQFIGA DTKFWLNILS DDMFGLANAA
250 260 270 280 290 300
MSDPNMDKIV YAPPLAINEE YQNDMVNYVN NCIDGEIVGQ TSLSPKFDEG KALLSKHRFK
310 320 330 340 350 360
VGQRLELLNY SNSTEIRVAR IQEICGRRMN VSITKKDFPE SLPDADDDRQ VFSSGSQYWI
370 380 390 400 410 420
DEGSFFIFPV GFAAVNGYQL NAKKEYIEHT NKIAQAIKNG ENPRYDSDDV TFDQLAKDPI
430 440 450 460 470 480
DPMIWRKVKV GQKFELIDPL AQQFNNLHVA SILKFCKTEG YLIVGMDGPD ALEDSFPIHI
490 500 510 520 530 540
NNTFMFPVGY AEKYNLELVP PDEFKGTFRW DEYLEKESAE TLPLDLFKPM PSQERLDKFK
550 560 570 580 590 600
VGLRLEAADM CENQFICPAT VKSVHGRLIN VNFDGWDEEF DELYDVDSHD ILPIGWCEAH
610
SYVLQPPKKY NY