AiPD: Autoinhibited Protein Database

Gene name	Sfmbt1
Protein name	Scm-like with four MBT domains protein 1
Names
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:54650
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

719-805 (Predicted disordered autoinhibitory region) PR

719-805 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9JMD1-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs50707539	92	K>R	No	EVA
rs3389286167	95	F>S	No	EVA
rs3389279972	127	V>M	No	EVA
rs3389316148	148	L>Q	No	EVA
rs3389316076	186	E>G	No	EVA
rs50366311	200	E>D	No	EVA
rs3389310608	200	E>K	No	EVA
rs3389309472	221	W>*	No	EVA
rs217370264	249	A>T	No	EVA
rs3389322108	285	W>*	No	EVA
rs3389241168	365	A>S	No	EVA
rs3389279958	372	C>S	No	EVA
rs3389241134	486	N>D	No	EVA
rs3389310571	510	S>T	No	EVA
rs3389280007	528	P>L	No	EVA
rs49263084	544	N>K	No	EVA
rs3389306772	550	S>N	No	EVA
rs3389306772	550	S>T	No	EVA
rs3389317059	559	D>G	No	EVA
rs3404169471	583	T>A	No	EVA
rs3389241194	595	E>Q	No	EVA
rs3389310595	596	F>L	No	EVA
rs3389312334	604	L>P	No	EVA
rs3413147359	609	N>T	No	EVA
rs3389317124	612	G>S	No	EVA
rs3404981346	634	H>Q	No	EVA
rs3389315085	640	K>R	No	EVA
rs1132190803	651	H>N	No	EVA
rs1132779804	652	S>N	No	EVA
rs1135115408	657	A>T	No	EVA
rs1132005550	658	L>M	No	EVA
rs1133082289	659	K>R	No	EVA
rs3389279947	664	R>K	No	EVA
rs3389317038	671	I>S	No	EVA
rs3389279946	738	P>T	No	EVA
rs213745311	753	T>S	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9JMD1

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
histone binding	Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
transcription corepressor activity	A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

Name	Definition
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
chromatin organization	The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of muscle organ development	Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q969R5	L3MBTL2	Lethal(3)malignant brain tumor-like protein 2	Homo sapiens (Human)	PR
Q9UQR0	SCML2	Sex comb on midleg-like protein 2	Homo sapiens (Human)	PR
Q96GD3	SCMH1	Polycomb protein SCMH1	Homo sapiens (Human)	PR
Q9Y468	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Homo sapiens (Human)	PR
Q96JM7	L3MBTL3	Lethal(3)malignant brain tumor-like protein 3	Homo sapiens (Human)	PR
Q9UHJ3	SFMBT1	Scm-like with four MBT domains protein 1	Homo sapiens (Human)	PR
A2A5N8	L3mbtl1	Lethal(3)malignant brain tumor-like protein 1	Mus musculus (Mouse)	PR
Q8BLB7	L3mbtl3	Lethal(3)malignant brain tumor-like protein 3	Mus musculus (Mouse)	PR
Q9JMD2	Sfmbt1	Scm-like with four MBT domains protein 1	Rattus norvegicus (Rat)	PR
B2D6M2	lin-61	Protein lin-61	Caenorhabditis elegans	PR
Q11193	sor-3	Sop-2-related protein 3	Caenorhabditis elegans	PR