A2A5N8
PR
Gene name |
L3mbtl1 (Kiaa0681, L3mbt, L3mbtl) |
Protein name |
Lethal(3)malignant brain tumor-like protein 1 |
Names |
H-l(3)mbt, H-l(3)mbt protein, L(3)mbt-like, L(3)mbt protein homolog |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:241764 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2A5N8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2A5N8-F1 | Predicted | AlphaFoldDB |
54 variants for A2A5N8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388611003 | 19 | G>W | No | EVA | |
| rs3388601369 | 27 | A>V | No | EVA | |
| rs3392515254 | 29 | D>G | No | EVA | |
| rs3388611860 | 30 | S>I | No | EVA | |
| rs3388601280 | 38 | P>H | No | EVA | |
| rs240394405 | 78 | S>N | No | EVA | |
| rs3388602030 | 99 | V>I | No | EVA | |
| rs3388604092 | 102 | L>Q | No | EVA | |
| rs3388594155 | 110 | P>S | No | EVA | |
| rs213416289 | 119 | R>Q | No | EVA | |
| rs3388610078 | 157 | V>D | No | EVA | |
| rs250782917 | 199 | S>P | No | EVA | |
| rs244164960 | 212 | S>A | No | EVA | |
| rs3388594177 | 225 | K>R | No | EVA | |
| rs3392496550 | 280 | W>C | No | EVA | |
| rs3392334073 | 282 | W>* | No | EVA | |
| rs3388610114 | 315 | G>A | No | EVA | |
| rs3392530421 | 324 | Q>H | No | EVA | |
| rs3388610976 | 378 | Q>* | No | EVA | |
| rs3388606303 | 392 | Q>H | No | EVA | |
| rs27346991 | 395 | R>C | No | EVA | |
| rs3388612948 | 399 | A>D | No | EVA | |
| rs3388610076 | 408 | V>A | No | EVA | |
| rs3388605420 | 428 | V>A | No | EVA | |
| rs3388602013 | 429 | D>E | No | EVA | |
| rs3388607411 | 450 | L>Q | No | EVA | |
| rs3388611858 | 454 | D>V | No | EVA | |
| rs3388602041 | 456 | W>L | No | EVA | |
| rs3388606457 | 459 | T>I | No | EVA | |
| rs3388605447 | 486 | P>L | No | EVA | |
| rs3388610297 | 489 | D>N | No | EVA | |
| rs3388594145 | 493 | P>T | No | EVA | |
| rs234515667 | 512 | N>T | No | EVA | |
| rs3392538826 | 524 | L>M | No | EVA | |
| rs3392515287 | 525 | V>L | No | EVA | |
| rs3392431866 | 526 | N>T | No | EVA | |
| rs3392496671 | 527 | M>R | No | EVA | |
| rs3388601348 | 530 | E>D | No | EVA | |
| rs3388609246 | 580 | W>S | No | EVA | |
| rs47880856 | 582 | S>Y | No | EVA | |
| rs3388606462 | 583 | K>R | No | EVA | |
| rs3388602031 | 589 | E>D | No | EVA | |
| rs3388607354 | 602 | P>L | No | EVA | |
| rs3388611054 | 609 | S>I | No | EVA | |
| rs3388601363 | 609 | S>R | No | EVA | |
| rs3388609202 | 611 | R>S | No | EVA | |
| rs3388604129 | 611 | R>T | No | EVA | |
| rs3388613002 | 612 | S>T | No | EVA | |
| rs3388609190 | 613 | P>S | No | EVA | |
| rs3388604108 | 614 | P>T | No | EVA | |
| rs3388607356 | 630 | T>I | No | EVA | |
| rs3388612964 | 637 | G>V | No | EVA | |
| rs249263228 | 678 | P>L | No | EVA | |
| rs3388606442 | 732 | L>F | No | EVA |
No associated diseases with A2A5N8
1 regional properties for A2A5N8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Exocyst complex component Sec8, N-terminal | 45 - 143 | IPR007191 |
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| chromatin lock complex | A chromatin silencing complex that binds and bridges separate nucleosomal histones resulting in heterochromatin assembly and chromatin looping. |
| condensed chromosome | A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
| identical protein binding | Binding to an identical protein or proteins. |
| methylated histone binding | Binding to a histone in which a residue has been modified by methylation. |
| nucleosome binding | Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. |
| SAM domain binding | Binding to a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes. |
| zinc ion binding | Binding to a zinc ion (Zn). |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin organization | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. |
| hemopoiesis | The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. |
| heterochromatin assembly | An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of gene expression, epigenetic | A process that modulates the frequency, rate or extent of gene expression through chromatin remodelling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal. |
| regulation of megakaryocyte differentiation | Any process that modulates the frequency, rate or extent of megakaryocyte differentiation. |
| regulation of mitotic nuclear division | Any process that modulates the frequency, rate or extent of mitosis. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q969R5 | L3MBTL2 | Lethal(3)malignant brain tumor-like protein 2 | Homo sapiens (Human) | PR |
| Q9UQR0 | SCML2 | Sex comb on midleg-like protein 2 | Homo sapiens (Human) | PR |
| Q96GD3 | SCMH1 | Polycomb protein SCMH1 | Homo sapiens (Human) | PR |
| Q9UHJ3 | SFMBT1 | Scm-like with four MBT domains protein 1 | Homo sapiens (Human) | PR |
| Q96JM7 | L3MBTL3 | Lethal(3)malignant brain tumor-like protein 3 | Homo sapiens (Human) | PR |
| Q9Y468 | L3MBTL1 | Lethal(3)malignant brain tumor-like protein 1 | Homo sapiens (Human) | PR |
| Q9JMD1 | Sfmbt1 | Scm-like with four MBT domains protein 1 | Mus musculus (Mouse) | PR |
| Q8BLB7 | L3mbtl3 | Lethal(3)malignant brain tumor-like protein 3 | Mus musculus (Mouse) | PR |
| Q9JMD2 | Sfmbt1 | Scm-like with four MBT domains protein 1 | Rattus norvegicus (Rat) | PR |
| B2D6M2 | lin-61 | Protein lin-61 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEGHTDMEIL | RTVKGSSTGE | VNVHLVARDS | AGPHPQLPTT | AFIIPTNAAT | LGLPSTALDV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PYPREPVHVG | ALERVAGSEP | VTATILPQLS | TGTGTNSTVR | LLDWTGVSAP | LPGSGMRFRI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NEYAPLNMIG | VERPRSPEQR | HEGGMARRDA | GIQHPDVHQD | RQDITSLEPP | VDASSCKCQA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CGPQQSSGLD | VGSSGDRCSQ | PFQKRSVIVE | NSGCTIASEL | LKPMKKRKHK | EYQSPSEESE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PEAVKQGEGK | DAEREPTPST | PENEEWSRSQ | LVSSEKKDGW | SWESYLEEQK | AVTAPVSLFQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DSQAVTHNKN | GFKLGMKLEG | IDPQHPSMYF | ILTVAEVCGY | RLRLHFDGYS | ECHDFWVNAN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SPDIHPAGWF | EKTGHKLQLP | KGYKEEEFSW | SQYLRSTKAQ | AAPKHLFVSQ | SHSTPPVGFQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VGMKLEAVDR | MNPSLVCVAS | VTDVVDSRFL | VHFDDWGDTY | DYWCDPSSPY | IHPVGWCQKQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GKPLTPPQDY | PDPDSFCWEK | YLEETGTSAV | PNWAFKVRPP | HSFLVNMKLE | AVDRRNPALI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RVASVEDVED | HRIKLHFDGW | SHNYDFWIDA | DHPDIHPAGW | CSKTGHPLEP | PLRPRESSSV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SPGGCPPLSH | RSPPHTKTSK | YNFHHRKCPT | PGCDGSGHVT | GKFTAHHCLS | GCPLAEKNQS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RLKAELSDSE | TAARKKNPSN | LSPRKKPRHQ | GRIGRPPKYR | KIPEEDLQAL | PPSVVHQSLF |
| 730 | 740 | 750 | 760 | 770 | 780 |
| MSTLPTHADR | PLSVCWEQHC | KLLPGVAGIS | ASTVSKWTIE | EVFGFVQTLT | GSEDQARLFK |
| 790 | 800 | 810 | 820 | ||
| DEMIDGEAFL | LLTQADIVKI | MSVKLGPALK | IYNAILMFKN | TDDAFK |