AiPD: Autoinhibited Protein Database

Gene name	L3mbtl3
Protein name	Lethal(3)malignant brain tumor-like protein 3
Names	L(3)mbt-like protein 3, MBT-1
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:237339
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

117-247 (Predicted disordered autoinhibitory region) PR

117-247 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8BLB7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389090109	30	G>R	No	EVA
rs3389104704	38	N>S	No	EVA
rs3389095752	39	E>G	No	EVA
rs3389095735	40	F>LR*	No	EVA
rs3389067553	63	T>K	No	EVA
rs3389090110	86	A>T	No	EVA
rs3389095741	94	C>R	No	EVA
rs33718159	140	S>N	No	EVA
rs33716791	154	D>E	No	EVA
rs3389097700	155	E>Q	No	EVA
rs3389104724	157	D>E	No	EVA
rs217398899	159	G>R	No	EVA
rs3389080427	192	D>E	No	EVA
rs3389093209	223	G>D	No	EVA
rs3412792858	378	E>K	No	EVA
rs3389104654	436	L>P	No	EVA
rs3389095566	453	Y>*	No	EVA
rs3389086441	455	E>Q	No	EVA
rs3389093061	477	K>R	No	EVA
rs3401089661	548	E>A	No	EVA
rs1135386408	558	C>F	No	EVA
rs1132706012	559	P>Q	No	EVA
rs222645540	588	I>V	No	EVA
rs213937300	607	P>S	No	EVA
rs257601720	621	R>S	No	EVA
rs234773790	639	E>D	No	EVA
rs3389086450	643	K>R	No	EVA
rs33711669	662	P>S	No	EVA
rs217972994	691	P>Q	No	EVA
rs264149771	720	V>A	No	EVA
rs234509339	723	A>P	No	EVA
rs583996125	729	A>P	No	EVA
rs585567821	732	A>P	No	EVA
rs583058516	735	P>A	No	EVA
rs225868632	753	V>A	No	EVA
rs585682493	754	Q>P	No	EVA
rs3389095780	825	G>E*	No	EVA
rs3389072142	827	E>G	No	EVA
rs3389103032	842	A>S	No	EVA

Type	Name	Position	InterPro Accession
domain	Cytochrome b5-like heme/steroid binding domain	5 - 89	IPR001199
domain	Fatty acid desaturase domain	136 - 406	IPR005804

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
histone binding	Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
identical protein binding	Binding to an identical protein or proteins.
zinc ion binding	Binding to a zinc ion (Zn).

Name	Definition
chromatin organization	The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
erythrocyte maturation	A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state.
granulocyte differentiation	The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.
macrophage differentiation	The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.
myeloid cell differentiation	The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
regulation of DNA methylation-dependent heterochromatin assembly	Any process that modulates the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q969R5	L3MBTL2	Lethal(3)malignant brain tumor-like protein 2	Homo sapiens (Human)	PR
Q9UQR0	SCML2	Sex comb on midleg-like protein 2	Homo sapiens (Human)	PR
Q96GD3	SCMH1	Polycomb protein SCMH1	Homo sapiens (Human)	PR
Q9UHJ3	SFMBT1	Scm-like with four MBT domains protein 1	Homo sapiens (Human)	PR
Q9Y468	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Homo sapiens (Human)	PR
Q96JM7	L3MBTL3	Lethal(3)malignant brain tumor-like protein 3	Homo sapiens (Human)	PR
A2A5N8	L3mbtl1	Lethal(3)malignant brain tumor-like protein 1	Mus musculus (Mouse)	PR
Q9JMD1	Sfmbt1	Scm-like with four MBT domains protein 1	Mus musculus (Mouse)	PR
Q9JMD2	Sfmbt1	Scm-like with four MBT domains protein 1	Rattus norvegicus (Rat)	PR
B2D6M2	lin-61	Protein lin-61	Caenorhabditis elegans	PR