Q9FLT5
PR
Gene name |
ABCA9 (ATH11, At5g61730, MAC9.4) |
Protein name |
ABC transporter A family member 9 |
Names |
ABC transporter ABCA.9, AtABCA9, ABC2 homolog 11 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G61730 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9FLT5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9FLT5-F1 | Predicted | AlphaFoldDB |
77 variants for Q9FLT5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_24807688_C_G | 71 | A>P | No | 1000Genomes | |
| tmp_5_24807676_G_C | 75 | L>V | No | 1000Genomes | |
| ENSVATH07462986 | 81 | E>G | No | 1000Genomes | |
| tmp_5_24807580_C_T | 107 | V>I | No | 1000Genomes | |
| ENSVATH03462388 | 118 | P>T | No | 1000Genomes | |
| ENSVATH07462984 | 120 | P>S | No | 1000Genomes | |
| tmp_5_24807412_G_C | 130 | P>R | No | 1000Genomes | |
| ENSVATH00746999 | 132 | E>D | No | 1000Genomes | |
| ENSVATH07462982 | 140 | H>Y | No | 1000Genomes | |
| ENSVATH12898874 | 141 | P>Q | No | 1000Genomes | |
| tmp_5_24807251_C_G | 184 | V>L | No | 1000Genomes | |
| tmp_5_24807233_C_A | 190 | A>S | No | 1000Genomes | |
| ENSVATH03462387 | 207 | D>G | No | 1000Genomes | |
| ENSVATH07462979 | 233 | V>L | No | 1000Genomes | |
| tmp_5_24806958_A_G | 241 | F>S | No | 1000Genomes | |
| ENSVATH03462386 | 269 | E>D | No | 1000Genomes | |
| tmp_5_24806762_T_C | 278 | I>V | No | 1000Genomes | |
| ENSVATH03462385 | 310 | L>V | No | 1000Genomes | |
| tmp_5_24806660_A_T | 312 | F>I | No | 1000Genomes | |
| tmp_5_24806529_C_T | 324 | G>S | No | 1000Genomes | |
| ENSVATH03462382 | 335 | K>E | No | 1000Genomes | |
| tmp_5_24806494_T_G | 335 | K>N | No | 1000Genomes | |
| tmp_5_24806475_C_G | 342 | V>L | No | 1000Genomes | |
| ENSVATH07462971 | 346 | V>L | No | 1000Genomes | |
| ENSVATH00746995 | 369 | I>M | No | 1000Genomes | |
| ENSVATH00746994 | 370 | G>S | No | 1000Genomes | |
| tmp_5_24806277_A_C | 378 | F>V | No | 1000Genomes | |
| ENSVATH07462970 | 382 | T>S | No | 1000Genomes | |
| tmp_5_24806231_G_A | 393 | A>V | No | 1000Genomes | |
| ENSVATH00746993 | 395 | S>L | No | 1000Genomes | |
| tmp_5_24806208_C_G | 401 | G>R | No | 1000Genomes | |
| ENSVATH07462969 | 412 | G>R | No | 1000Genomes | |
| tmp_5_24806047_C_A | 427 | W>C | No | 1000Genomes | |
| tmp_5_24806039_C_A | 430 | G>V | No | 1000Genomes | |
| ENSVATH00746990 | 436 | F>C | No | 1000Genomes | |
| ENSVATH03462378 | 447 | P>T | No | 1000Genomes | |
| tmp_5_24805912_T_G | 472 | K>N | No | 1000Genomes | |
| tmp_5_24805911_C_G | 473 | V>L | No | 1000Genomes | |
| ENSVATH07462964 | 487 | P>Q | No | 1000Genomes | |
| ENSVATH00746989 | 511 | D>N | No | 1000Genomes | |
| ENSVATH14644285 | 515 | D>A | No | 1000Genomes | |
| tmp_5_24805632_G_A | 543 | T>I | No | 1000Genomes | |
| ENSVATH12898834 | 556 | I>V | No | 1000Genomes | |
| tmp_5_24805430_C_G | 569 | G>A | No | 1000Genomes | |
| ENSVATH07462951 | 576 | I>T | No | 1000Genomes | |
| ENSVATH03462375 | 600 | S>F | No | 1000Genomes | |
| ENSVATH12898817 | 657 | T>I | No | 1000Genomes | |
| tmp_5_24804859_C_T | 660 | A>T | No | 1000Genomes | |
| tmp_5_24804801_A_G | 679 | I>T | No | 1000Genomes | |
| ENSVATH07462943 | 679 | I>V | No | 1000Genomes | |
| ENSVATH07462942 | 688 | V>I | No | 1000Genomes | |
| ENSVATH03462363 | 707 | D>N | No | 1000Genomes | |
| ENSVATH03462359 | 732 | S>G | No | 1000Genomes | |
| tmp_5_24804473_T_C | 751 | R>G | No | 1000Genomes | |
| ENSVATH12898753 | 761 | V>I | No | 1000Genomes | |
| ENSVATH07462934 | 762 | A>T | No | 1000Genomes | |
| ENSVATH07462932 | 767 | I>L | No | 1000Genomes | |
| ENSVATH07462931 | 767 | I>T | No | 1000Genomes | |
| tmp_5_24804411_T_A | 771 | K>N | No | 1000Genomes | |
| ENSVATH12898751 | 774 | A>V | No | 1000Genomes | |
| ENSVATH07462929 | 779 | K>R | No | 1000Genomes | |
| ENSVATH07462928 | 780 | R>I | No | 1000Genomes | |
| ENSVATH12898748 | 786 | L>I | No | 1000Genomes | |
| ENSVATH12898747 | 787 | K>I | No | 1000Genomes | |
| tmp_5_24804274_A_G | 788 | V>A | No | 1000Genomes | |
| tmp_5_24804247_A_G | 797 | F>S | No | 1000Genomes | |
| tmp_5_24804238_A_C | 800 | F>C | No | 1000Genomes | |
| tmp_5_24804072_T_C | 828 | D>G | No | 1000Genomes | |
| ENSVATH07462924 | 843 | I>M | No | 1000Genomes | |
| tmp_5_24804025_C_T | 844 | A>T | No | 1000Genomes | |
| tmp_5_24804019_G_C | 846 | R>G | No | 1000Genomes | |
| ENSVATH12898745 | 847 | A>T | No | 1000Genomes | |
| ENSVATH00746985 | 868 | A>T | No | 1000Genomes | |
| ENSVATH00746984 | 892 | L>I | No | 1000Genomes | |
| tmp_5_24803707_C_T | 910 | G>E | No | 1000Genomes | |
| ENSVATH14644280 | 913 | A>T | No | 1000Genomes | |
| tmp_5_24803608_A_G | 943 | V>A | No | 1000Genomes |
No associated diseases with Q9FLT5
2 regional properties for Q9FLT5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Argininosuccinate synthase, conserved site | 10 - 18 | IPR018223-1 |
| conserved_site | Argininosuccinate synthase, conserved site | 117 - 128 | IPR018223-2 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ABC-type transporter activity | Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATPase-coupled transmembrane transporter activity | Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. |
| fatty acid transmembrane transporter activity | Enables the transfer of fatty acids from one side of a membrane to the other. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. |
| lipid transporter activity | Enables the directed movement of lipids into, out of or within a cell, or between cells. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| lipid transport | The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
| seed development | The process whose specific outcome is the progression of the seed over time, from its formation to the mature structure. A seed is a propagating organ formed in the sexual reproductive cycle of gymnosperms and angiosperms, consisting of a protective coat enclosing an embryo and food reserves. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8WWZ4 | ABCA10 | ATP-binding cassette sub-family A member 10 | Homo sapiens (Human) | PR |
| Q8N139 | ABCA6 | ATP-binding cassette sub-family A member 6 | Homo sapiens (Human) | PR |
| Q8IUA7 | ABCA9 | ATP-binding cassette sub-family A member 9 | Homo sapiens (Human) | PR |
| P78363 | ABCA4 | Retinal-specific phospholipid-transporting ATPase ABCA4 | Homo sapiens (Human) | PR |
| Q8WWZ7 | ABCA5 | Cholesterol transporter ABCA5 | Homo sapiens (Human) | PR |
| Q86UK0 | ABCA12 | Glucosylceramide transporter ABCA12 | Homo sapiens (Human) | PR |
| Q8K449 | Abca9 | ATP-binding cassette sub-family A member 9 | Mus musculus (Mouse) | PR |
| Q8K448 | Abca5 | Cholesterol transporter ABCA5 | Mus musculus (Mouse) | PR |
| Q8K442 | Abca8a | ABC-type organic anion transporter ABCA8A | Mus musculus (Mouse) | PR |
| P34358 | ced-7 | ABC transporter ced-7 | Caenorhabditis elegans | PR |
| Q84K47 | ABCA2 | ABC transporter A family member 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FKF2 | ABCA11 | ABC transporter A family member 11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTLREGLPLF | HQQFTALFKK | NLLLSWRNKR | ATCLHLFSSF | FFILLIFSIE | ESSKASDLTS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TRHKNVTDPK | ALVSLPILPC | EDKFFVRLPC | FDFVWSGNQS | RRVTDIVSAI | MANNPGRPIP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TNKVQSFTKP | EEVDAWFMSH | PSQVTGALHF | VEKNATVISY | GIQTNSSSEK | KRGRREDPTF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KFLVPLQIAA | EREIARSLIG | DPKFSWDFGF | KEFARPAIGG | EVIISAFYLM | GPVFFLAFSM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FGFVLQLGSV | VTEKELKLRE | AMTTMGVYES | AYWLSWLIWE | GILTFVSSLF | LVLFGMMFQF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EFFLKNSFVL | VFLLFFLFQF | NMIGLAFALS | SIISKSSSAT | TVGFLVFLVG | FITQIVTTAG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FPYSSAYSIG | SRVIWSLFPP | NTFSAGLQLL | LEATSSPGDS | GISWSERAIC | AGGESTCVIT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TNKIYIWLVG | TFFFWFVLAL | YFDNIIPNAS | GVRKSIFYFL | KPSYWTGKEG | NKVEEGSICS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| CIGSVPPVEH | ITPEDEDVLE | EEILVKQQAM | DGRVDPNIAV | QIHGLAKTYP | GTTKLGCCKC |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TKTSPFHAVK | GLWMNIAKDQ | LFCLLGPNGA | GKTTTISCLT | GINPVTGGDA | KIYGNSIRSS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VGMSNIRKMI | GVCPQFDILW | DALSSEEHLH | LFASIKGLPP | SSIKSIAEKL | LVDVKLTGSA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KIRAGSYSGG | MKRRLSVAIA | LIGDPKLVFL | DEPTTGMDPI | TRRHVWDIIQ | ESKKGRAIIL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TTHSMEEADI | LSDRIGIMAK | GRLRCIGTSI | RLKSRFGTGF | VATVSFIENK | KDGAPEPLKR |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FFKERLKVEP | TEENKAFMTF | VIPHDKEQLL | KGFFAELQDR | ESEFGIADIQ | LGLATLEEVF |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LNIARRAELE | SATVEGTMVT | LELESGIAVE | IPVGARFVGI | PGTENAENPR | GLMVEVYWQQ |
| 910 | 920 | 930 | 940 | ||
| DGSGSMCISG | HSAEMRIPEN | VSVIYEPSSQ | VLGHGQRRVR | GIVIDYESNN |