Q8K442
PR
Gene name |
Abca8a |
Protein name |
ABC-type organic anion transporter ABCA8A |
Names |
ATP-binding cassette sub-family A member 8A |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:217258 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8K442
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8K442-F1 | Predicted | AlphaFoldDB |
93 variants for Q8K442
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389207463 | 17 | C>F | No | EVA | |
| rs250803674 | 45 | I>T | No | EVA | |
| rs235965615 | 50 | L>M | No | EVA | |
| rs3389216313 | 75 | F>Y | No | EVA | |
| rs3389176168 | 76 | M>T | No | EVA | |
| rs3389176145 | 86 | T>I | No | EVA | |
| rs3389222462 | 113 | M>T | No | EVA | |
| rs3389216381 | 114 | T>R | No | EVA | |
| rs247941291 | 140 | I>L | No | EVA | |
| rs27050016 | 166 | Y>S | No | EVA | |
| rs27050021 | 232 | R>C | No | EVA | |
| rs3389176214 | 250 | K>R | No | EVA | |
| rs27050026 | 284 | S>L | No | EVA | |
| rs251507700 | 299 | F>L | No | EVA | |
| rs3389222397 | 303 | F>I | No | EVA | |
| rs3389229179 | 316 | L>S | No | EVA | |
| rs3389213791 | 332 | L>P | No | EVA | |
| rs3389183871 | 342 | G>V | No | EVA | |
| rs1135064706 | 406 | D>N | No | EVA | |
| rs3402382394 | 423 | S>V | No | EVA | |
| rs3389188618 | 437 | S>P | No | EVA | |
| rs234439215 | 470 | M>I | No | EVA | |
| rs262410736 | 470 | M>T | No | EVA | |
| rs3389188644 | 488 | I>L | No | EVA | |
| rs262017523 | 493 | R>H | No | EVA | |
| rs3389210214 | 499 | D>G | No | EVA | |
| rs3389222473 | 632 | D>Y | No | EVA | |
| rs27050034 | 656 | F>L | No | EVA | |
| rs3402765995 | 715 | S>C | No | EVA | |
| rs3389216383 | 718 | C>Y | No | EVA | |
| rs3389217302 | 722 | R>* | No | EVA | |
| rs3402792404 | 744 | L>M | No | EVA | |
| rs3389216310 | 760 | Y>H | No | EVA | |
| rs3389201327 | 765 | R>I | No | EVA | |
| rs3389176147 | 782 | T>S | No | EVA | |
| rs225099143 | 867 | V>I | No | EVA | |
| rs256224590 | 868 | L>W | No | EVA | |
| rs3389176127 | 883 | M>I | No | EVA | |
| rs242098850 | 894 | A>T | No | EVA | |
| rs3389213694 | 904 | Q>L | No | EVA | |
| rs228505930 | 908 | P>L | No | EVA | |
| rs3389188599 | 947 | G>D | No | EVA | |
| rs221682026 | 996 | A>T | No | EVA | |
| rs236534530 | 1018 | D>N | No | EVA | |
| rs213154038 | 1020 | L>V | No | EVA | |
| rs259356576 | 1025 | L>S | No | EVA | |
| rs3411747160 | 1077 | A>V | No | EVA | |
| rs225071811 | 1086 | F>L | No | EVA | |
| rs3389207440 | 1097 | T>R | No | EVA | |
| rs3389225011 | 1099 | G>S | No | EVA | |
| rs3389188643 | 1100 | D>E | No | EVA | |
| rs3389216315 | 1100 | D>G | No | EVA | |
| rs3389183912 | 1101 | L>R | No | EVA | |
| rs3389211038 | 1101 | L>V | No | EVA | |
| rs3389210991 | 1102 | F>L | No | EVA | |
| rs3389216336 | 1104 | Q>* | No | EVA | |
| rs221480499 | 1153 | I>F | No | EVA | |
| rs255526154 | 1159 | I>T | No | EVA | |
| rs223079875 | 1162 | F>Y | No | EVA | |
| rs255485791 | 1165 | I>T | No | EVA | |
| rs27050038 | 1189 | I>V | No | EVA | |
| rs219096617 | 1198 | S>F | No | EVA | |
| rs3389213783 | 1214 | V>G | No | EVA | |
| rs3389217347 | 1216 | L>F | No | EVA | |
| rs3389210220 | 1217 | R>L | No | EVA | |
| rs27050044 | 1221 | R>S | No | EVA | |
| rs236450074 | 1223 | F>L | No | EVA | |
| rs3389183887 | 1230 | T>M | No | EVA | |
| rs3389216351 | 1231 | D>E | No | EVA | |
| rs3389176188 | 1264 | T>I | No | EVA | |
| rs3389207460 | 1266 | N>K | No | EVA | |
| rs3389214778 | 1287 | E>* | No | EVA | |
| rs3389207447 | 1288 | Y>* | No | EVA | |
| rs3389207421 | 1299 | S>R | No | EVA | |
| rs3389183841 | 1318 | V>I | No | EVA | |
| rs3389229234 | 1319 | G>* | No | EVA | |
| rs227065705 | 1326 | A>P | No | EVA | |
| rs3389176219 | 1330 | T>I | No | EVA | |
| rs3389183840 | 1333 | K>* | No | EVA | |
| rs6171634 | 1351 | S>G | No | EVA | |
| rs245018298 | 1421 | V>M | No | EVA | |
| rs3389214781 | 1444 | S>T | No | EVA | |
| rs234849330 | 1466 | T>K | No | EVA | |
| rs3389148478 | 1471 | L>V | No | EVA | |
| rs3389213745 | 1492 | S>C | No | EVA | |
| rs3389229221 | 1492 | S>T | No | EVA | |
| rs3389207465 | 1493 | G>D | No | EVA | |
| rs3389211034 | 1538 | A>D | No | EVA | |
| rs3389217275 | 1548 | M>K | No | EVA | |
| rs3389188665 | 1569 | T>S | No | EVA | |
| rs27007088 | 1600 | D>E | No | EVA | |
| rs3389213766 | 1614 | L>F | No | EVA | |
| rs1132287258 | 1620 | A>T | No | EVA |
No associated diseases with Q8K442
7 regional properties for Q8K442
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ABC transporter-like, ATP-binding domain | 478 - 713 | IPR003439-1 |
| domain | ABC transporter-like, ATP-binding domain | 1284 - 1517 | IPR003439-2 |
| domain | AAA+ ATPase domain | 506 - 690 | IPR003593-1 |
| domain | AAA+ ATPase domain | 1314 - 1494 | IPR003593-2 |
| domain | ABC-2 type transporter, transmembrane domain | 32 - 416 | IPR013525-1 |
| domain | ABC-2 type transporter, transmembrane domain | 935 - 1157 | IPR013525-2 |
| conserved_site | ABC transporter-like, conserved site | 615 - 629 | IPR017871 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ABC-type transporter activity | Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. |
| ABC-type xenobiotic transporter activity | Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out). |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATPase-coupled transmembrane transporter activity | Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. |
| lipid transporter activity | Enables the directed movement of lipids into, out of or within a cell, or between cells. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cholesterol efflux | The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. |
| cholesterol transport | The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| lipid transport | The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
| positive regulation of cholesterol efflux | Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. |
| regulation of cholesterol efflux | Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. |
| sphingomyelin biosynthetic process | The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine. |
| xenobiotic transport | The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q86UK0 | ABCA12 | Glucosylceramide transporter ABCA12 | Homo sapiens (Human) | PR |
| P78363 | ABCA4 | Retinal-specific phospholipid-transporting ATPase ABCA4 | Homo sapiens (Human) | PR |
| Q8IUA7 | ABCA9 | ATP-binding cassette sub-family A member 9 | Homo sapiens (Human) | PR |
| Q8N139 | ABCA6 | ATP-binding cassette sub-family A member 6 | Homo sapiens (Human) | PR |
| Q8WWZ4 | ABCA10 | ATP-binding cassette sub-family A member 10 | Homo sapiens (Human) | PR |
| Q8WWZ7 | ABCA5 | Cholesterol transporter ABCA5 | Homo sapiens (Human) | PR |
| Q8K448 | Abca5 | Cholesterol transporter ABCA5 | Mus musculus (Mouse) | PR |
| Q8K449 | Abca9 | ATP-binding cassette sub-family A member 9 | Mus musculus (Mouse) | PR |
| P34358 | ced-7 | ABC transporter ced-7 | Caenorhabditis elegans | PR |
| Q84K47 | ABCA2 | ABC transporter A family member 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FKF2 | ABCA11 | ABC transporter A family member 11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FLT5 | ABCA9 | ABC transporter A family member 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVKREINVCQ | QTWALLCKNL | LRKKRLKRDT | FLEFLYTALI | LLSLILFLQL | HEVYDFSSLP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DVDLGRIDSF | NDSTFMIVYT | PITPTTQRIM | DRVSLVSYMT | GRKILASPNE | ENMTELISMR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FSDVVGVIFT | NAYSYNLKFI | KGARIPTIKE | HQDHTAHCHS | YGEIIYCGLS | EFWRDGFVAL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QAAINAAIIE | VTTNHSVMEE | MMSLTGKYIK | IDSFVGQEGT | TTDCFLFFCI | IRFSPLTYYI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SAGVTRERKK | MKGLMAVMGL | RDSAFWLSWG | LLYGVIVFVV | TLLSTTIVKL | VQFVFLTGFM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VIFSLFFFYG | LSLISLSFLM | SVLLKKSFLT | DLVVFLLTVS | CGSLGFTALY | RYLPVSLEWL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LSLLSPFAFM | LGMVQLLRLD | YDVNSNADPM | GNPNEVIGTI | FMLFFDGVFY | LLLTFYFEKV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LPSKSFHDKT | YWHACKSHFF | LIDYSFYIRT | ALDNETDYEF | SDDSFEPVSM | EFHGKEAIRI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RNLTKDYIQK | SKRTEALKDL | TLDVYKGQIT | AILGHSGAGK | STLLNVLSGL | CVPTKGWVTI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| HNNKLSEMTD | LENISKLTGV | CPQCNVQFDF | LTVRENLRLF | AKIKGIQAHE | VDNEVQRVLL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ELDMKNTQNI | LVQNLSGGQK | RKLTFGIAIL | GDPQIFLLDE | PTAGLDPFSR | HRVWNFLKER |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RADRVVLFST | QFMDEADILA | DRKVFISKGK | LKCAGSSLFL | KKKWGIGYHL | SLQLSETCVH |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ERITSLVKQH | IPDSKLSAES | EGKLSYILPL | ERTNKFPDLY | RDLERSPDLG | IENYGVSITT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LTEVFLKLEG | KSSIDQSDIG | MTEDVQAGGA | RSPERFAEVE | QLVSLLNGRC | KMKGGMALWW |
| 850 | 860 | 870 | 880 | 890 | 900 |
| QQLCAVTRLR | FLKLKHERKS | IVILILVLGI | GLLHILSANI | YRMVRQSDYC | WELAPHMYFL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| TPGQQPQPPL | TNLLIVNKTG | AKIDDFIHSL | EQQNIALEVD | AFGTRNGTED | SQYNGAIILS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| GDEKNYNFTL | ACNTKRLNCF | PVLVDIVSNG | LLGLFAPSAH | IQTDRSTFPE | ENDHRKFDYL |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| AYFFLWVLLM | ACVPPYISMT | SIDDYKNRAQ | FQLWISGLSP | SAYWFGQALF | EVPVYCALIL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| SIFIAFYASA | PPESKFTVGD | LFIQILYVGG | YAMSVIFMTY | VISFIYRKGR | KNSGLWSLCF |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| YIVSFFSMCF | MLIDYFRDIS | LFVLIALVPP | ATLGGCTLLH | FENREFSEII | FEPEREYSYL |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| FFLAPLLHFA | IFVVILRCME | RKFGMKTMRT | DPVFRISPRS | DRVFNNPEDP | DGEDEDVSQE |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| RVWTANALTS | ADFQEKPAII | ASCLRKEYKG | KKKCFVLKSK | KKIATRNISF | CVRKGEVVGL |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| LGHNGAGKST | SIKMITGETK | PSAGQVLLKG | SSTGDTPGFL | GYCPQENALW | LNLTVREHLE |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| IFAAIKGMRK | SDANVAIERL | ADALKLQDQL | KSPVKTLSEG | VKRKLCFVLS | ILGNPSVVLL |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| DEPSTGMDPE | GQQQMWQAIQ | ATFSNTERGA | LLTTHYMAEA | EAVCDRVAIM | VSGRLRCIGS |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| IQHLKSKFGK | EYLLEMKVKT | PSQVEPLNTE | IMRLFPQAAR | QERYSSLMVY | KLPREDVQPL |
| 1570 | 1580 | 1590 | 1600 | 1610 | |
| SQAFFKLETV | KQSFDLEEYS | LSQSTLEQVF | LELSKEQELD | GFEEELDPSV | KWKLLPQEEA |