Q8K449
PR
Gene name |
Abca9 |
Protein name |
ATP-binding cassette sub-family A member 9 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:217262 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8K449
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8K449-F1 | Predicted | AlphaFoldDB |
82 variants for Q8K449
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs27036886 | 57 | A>T | No | EVA | |
| rs27036887 | 92 | N>T | No | EVA | |
| rs231095654 | 105 | I>V | No | EVA | |
| rs3389148436 | 120 | N>H | No | EVA | |
| rs244840076 | 149 | T>I | No | EVA | |
| rs3411342048 | 150 | K>* | No | EVA | |
| rs27036911 | 193 | I>T | No | EVA | |
| rs3389214842 | 212 | M>L | No | EVA | |
| rs3389216301 | 213 | P>S | No | EVA | |
| rs256901805 | 222 | A>T | No | EVA | |
| rs3389211290 | 230 | C>G | No | EVA | |
| rs237834291 | 271 | S>G | No | EVA | |
| rs222479015 | 272 | L>P | No | EVA | |
| rs3389201310 | 309 | F>L | No | EVA | |
| rs3389211281 | 316 | T>I | No | EVA | |
| rs3389176156 | 323 | V>M | No | EVA | |
| rs27036928 | 335 | I>V | No | EVA | |
| rs237945957 | 337 | I>L | No | EVA | |
| rs3389201338 | 339 | T>I | No | EVA | |
| rs3389183843 | 363 | C>R | No | EVA | |
| rs3389207452 | 370 | F>Y | No | EVA | |
| rs211931184 | 427 | K>N | No | EVA | |
| rs3389176151 | 473 | P>Q | No | EVA | |
| rs3402146913 | 487 | K>R | No | EVA | |
| rs3389176134 | 492 | G>* | No | EVA | |
| rs3389148415 | 516 | L>I | No | EVA | |
| rs3389213510 | 517 | G>R | No | EVA | |
| rs3389225005 | 519 | S>N | No | EVA | |
| rs253269947 | 557 | V>I | No | EVA | |
| rs27036952 | 560 | I>L | No | EVA | |
| rs238649034 | 603 | Q>R | No | EVA | |
| rs3389210217 | 612 | D>Y | No | EVA | |
| rs218108611 | 665 | A>T | No | EVA | |
| rs254559205 | 665 | A>V | No | EVA | |
| rs3389217334 | 693 | R>* | No | EVA | |
| rs3389214843 | 694 | L>V | No | EVA | |
| rs3389229149 | 704 | K>N | No | EVA | |
| rs265263140 | 718 | N>S | No | EVA | |
| rs220803505 | 723 | P>Q | No | EVA | |
| rs250782712 | 735 | S>P | No | EVA | |
| rs221317888 | 781 | M>I | No | EVA | |
| rs3389216300 | 782 | T>A | No | EVA | |
| rs255236635 | 807 | R>H | No | EVA | |
| rs221645946 | 816 | M>V | No | EVA | |
| rs256963145 | 820 | V>A | No | EVA | |
| rs238784104 | 822 | L>P | No | EVA | |
| rs3389222428 | 824 | Q>H | No | EVA | |
| rs3389210267 | 840 | L>V | No | EVA | |
| rs3389214775 | 842 | R>M | No | EVA | |
| rs27036984 | 883 | V>I | No | EVA | |
| rs27036985 | 910 | D>E | No | EVA | |
| rs27036991 | 924 | S>N | No | EVA | |
| rs265084046 | 967 | A>D | No | EVA | |
| rs249573232 | 1002 | R>L | No | EVA | |
| rs3402792903 | 1104 | L>S | No | EVA | |
| rs3389213782 | 1140 | F>Y | No | EVA | |
| rs262190192 | 1195 | T>A | No | EVA | |
| rs246525626 | 1211 | H>Q | No | EVA | |
| rs257610044 | 1253 | P>L | No | EVA | |
| rs3389183898 | 1260 | V>I | No | EVA | |
| rs27037058 | 1275 | Q>R | No | EVA | |
| rs3389225083 | 1290 | E>D | No | EVA | |
| rs3389207475 | 1292 | I>M | No | EVA | |
| rs236019372 | 1292 | I>T | No | EVA | |
| rs3389188623 | 1295 | T>R | No | EVA | |
| rs214875244 | 1302 | M>T | No | EVA | |
| rs3389188612 | 1319 | E>* | No | EVA | |
| rs3389188612 | 1320 | V>* | No | EVA | |
| rs3389222435 | 1352 | K>R | No | EVA | |
| rs3389222414 | 1357 | G>D | No | EVA | |
| rs3389229238 | 1418 | R>M | No | EVA | |
| rs3389207511 | 1419 | T>I | No | EVA | |
| rs236991895 | 1439 | P>S | No | EVA | |
| rs3389222424 | 1493 | M>L | No | EVA | |
| rs3412161855 | 1501 | I>N | No | EVA | |
| rs3389148465 | 1536 | R>S | No | EVA | |
| rs3402792961 | 1540 | Q>R | No | EVA | |
| rs3389176208 | 1548 | S>C | No | EVA | |
| rs242761831 | 1561 | R>Q | No | EVA | |
| rs3389207509 | 1583 | S>G | No | EVA | |
| rs261713656 | 1610 | N>S | No | EVA | |
| rs3402794138 | 1618 | L>F | No | EVA |
No associated diseases with Q8K449
7 regional properties for Q8K449
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ABC transporter-like, ATP-binding domain | 481 - 716 | IPR003439-1 |
| domain | ABC transporter-like, ATP-binding domain | 1287 - 1520 | IPR003439-2 |
| domain | AAA+ ATPase domain | 509 - 693 | IPR003593-1 |
| domain | AAA+ ATPase domain | 1317 - 1497 | IPR003593-2 |
| domain | ABC-2 type transporter, transmembrane domain | 30 - 419 | IPR013525-1 |
| domain | ABC-2 type transporter, transmembrane domain | 996 - 1218 | IPR013525-2 |
| conserved_site | ABC transporter-like, conserved site | 618 - 632 | IPR017871 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ABC-type transporter activity | Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATPase-coupled transmembrane transporter activity | Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. |
| lipid transporter activity | Enables the directed movement of lipids into, out of or within a cell, or between cells. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| lipid transport | The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q86UK0 | ABCA12 | Glucosylceramide transporter ABCA12 | Homo sapiens (Human) | PR |
| P78363 | ABCA4 | Retinal-specific phospholipid-transporting ATPase ABCA4 | Homo sapiens (Human) | PR |
| Q8N139 | ABCA6 | ATP-binding cassette sub-family A member 6 | Homo sapiens (Human) | PR |
| Q8WWZ4 | ABCA10 | ATP-binding cassette sub-family A member 10 | Homo sapiens (Human) | PR |
| Q8WWZ7 | ABCA5 | Cholesterol transporter ABCA5 | Homo sapiens (Human) | PR |
| Q8IUA7 | ABCA9 | ATP-binding cassette sub-family A member 9 | Homo sapiens (Human) | PR |
| Q8K442 | Abca8a | ABC-type organic anion transporter ABCA8A | Mus musculus (Mouse) | PR |
| Q8K448 | Abca5 | Cholesterol transporter ABCA5 | Mus musculus (Mouse) | PR |
| P34358 | ced-7 | ABC transporter ced-7 | Caenorhabditis elegans | PR |
| Q84K47 | ABCA2 | ABC transporter A family member 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FKF2 | ABCA11 | ABC transporter A family member 11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FLT5 | ABCA9 | ABC transporter A family member 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRKRHLRLGQ | QMWALLCKNW | LRKFRMRRET | LLEWLFSLLL | ILFVYQLSSN | LHQVHDAPEM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SVVDLGRVDN | FNDSNYMMVF | APESEATHEI | MNKVASAPFM | KGRTIVACPD | EKSMNELDLN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YSIDAVRVIF | KDTFSYHLKF | SWGQRIPKTK | EHKDHSAPCE | PLNNKMICEN | SAFWEKGFVA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FQAAINAGII | EMITNHSVME | ELMSVIGSNM | KMPPFIAQGG | VATDFFIFFC | VISFSSLIYY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSVNITQERQ | YMTTLMAMMG | LRESAFWLSW | SLMYAGFILV | VAVLMSLIVK | SAQVVVLTGF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MVVFLLFLFY | GLSLITLSFL | MSVLIKKPFL | TGLAIFILTV | FWGSLGFTAL | YKHLPAFVEW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TLCFLSPFAF | TTGMAQLIHL | DYDVNSNVNL | NSPNNSYLIM | ATLFMLVLDA | LLYLVLALYF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DKITLSKYGH | QRSPLFFLKS | SYWFKRRGAS | HVVLENEIDS | DPSLNDSLEP | VSPEFQGKEA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IRIKNLKKEY | SGKHGKVEAL | RGLGFDIYEG | QITALLGHSG | AGKTTLINTL | SGLSPPTTGS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VTIYNQTVSE | MDDSDAVLTI | TGVCPQSNVQ | FGFLTVRENL | RLFAKIKGIL | PHEVEQEVQQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VLQDLEMENI | QDILAQNLSG | GQKRKLTLGI | AILGDPQVLL | LDEPTAGLDP | LSRHRIWNLL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KERRAGRVIV | FSTQFMDEAD | ILADRKVFIS | NGRLKCAGSS | LFLKKKWGIG | YHLSLHLNEA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| CDPEGITSLV | KKHISDARLT | TQSEERLVYI | LPLERTNKFP | DLYRDLDRCS | NQGIEDYGVS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| MTTLNEVFLK | LEGKSMADES | DVGICGRLQS | DGARDMESLV | ELEQVLSLDS | SGSSVSGMAL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| WRQQLCAVAK | VRFFKLKNER | KSLMTVLLLF | GISFVPQLLE | HLVYKVYHKS | YSWGLSPSMY |
| 910 | 920 | 930 | 940 | 950 | 960 |
| FLSPGQPPQD | PLTHLLVINR | TGSSIDNFVH | ALRQQGIALD | LDALGTRNGT | EEALYNGAIT |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| VLGEEKALRF | SVACNAKRLN | CFPVLMDIIS | NGLLGIFNSS | ERIQTDRSTV | FEEHMLYEYG |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| FMSNAFFWIP | VAASLTPYIA | MGSISDHKKK | VLSQLWTSGL | YPSAYWCGQA | LVDIPIYFLI |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LFLMQIMDSV | FSSEEFISVM | ESLLIQIPCS | IGYASSLIFM | TYVISFIFRN | GRKNSGIWSF |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| FFLIVTIFFI | IATDINEYGF | LELLICTFLV | PPFTLIGSLL | IFSEVSYDSV | DYLGTSESQL |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| VFLALLIPYL | HFLLFFFILR | CLERYLRKKS | LRVDPVFRIS | PRSCPAVPNP | EEPGEEDEDV |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| QMERVRTTGA | MATLQTDEKP | VIIASCLRKE | YIGRTKRCFS | KMKKKIATRN | ISFCVKKGEV |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| LGLLGHNGAG | KSTTISMITG | DTIPTAGQVF | LKGSGGGAAL | GFLGYCPQEN | VLWPNLTVKE |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| HLELYAAVKG | LKKKDAVVTI | TRLVNALKLQ | DHLKALVRTL | SEGVKRKLCF | VLSILGNPPV |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| VLLDEPSTGM | DPEGQQQMWQ | AIRATFTNTE | RGALLTTHYM | AEAEAVCDRV | AIMVSGRLRC |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| IGSIQHLKSK | FGKDYLLEMK | VKTPSQVEPL | NTEIMRLFPQ | AARQERYSSL | MVYKLPVEDV |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| RPLSEAFFKL | ERLKENFDLE | EYSLSQSTLE | QVFLELSKEQ | ELDDFGEEAN | SSVKWKLLPQ |
| EEL |