Q84K47
PR
Gene name |
ABCA2 (ATH1, At3g47730, T23J7.60) |
Protein name |
ABC transporter A family member 2 |
Names |
ABC transporter ABCA.2, AtABCA2, ABC2 homolog 1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G47730 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q84K47
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q84K47-F1 | Predicted | AlphaFoldDB |
66 variants for Q84K47
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_17598605_G_A | 75 | P>L | No | 1000Genomes | |
| ENSVATH06262718 | 76 | P>T | No | 1000Genomes | |
| tmp_3_17598507_T_C | 108 | N>D | No | 1000Genomes | |
| ENSVATH06262713 | 141 | P>A | No | 1000Genomes | |
| tmp_3_17598169_A_C | 151 | I>M | No | 1000Genomes | |
| tmp_3_17598171_T_C | 151 | I>V | No | 1000Genomes | |
| tmp_3_17598062_T_A | 187 | Q>L | No | 1000Genomes | |
| tmp_3_17597924_G_T | 203 | N>K | No | 1000Genomes | |
| tmp_3_17597914_C_T | 207 | V>I | No | 1000Genomes | |
| tmp_3_17597844_G_A | 230 | T>I | No | 1000Genomes | |
| ENSVATH06262705 | 264 | V>A | No | 1000Genomes | |
| tmp_3_17597672_C_T | 264 | V>I | No | 1000Genomes | |
| tmp_3_17597653_C_T | 270 | W>* | No | 1000Genomes | |
| ENSVATH14395794 | 271 | L>F | No | 1000Genomes | |
| tmp_3_17597648_A_C | 272 | S>A | No | 1000Genomes | |
| tmp_3_17597546_G_C | 306 | P>A | No | 1000Genomes | |
| tmp_3_17597525_T_C | 313 | M>V | No | 1000Genomes | |
| ENSVATH06262702 | 349 | V>I | No | 1000Genomes | |
| ENSVATH00406266 | 356 | S>I | No | 1000Genomes | |
| ENSVATH14395790 | 407 | C>S | No | 1000Genomes | |
| ENSVATH14395789 | 408 | G>S | No | 1000Genomes | |
| ENSVATH00406264 | 409 | P>S | No | 1000Genomes | |
| ENSVATH06262699 | 411 | D>N | No | 1000Genomes | |
| ENSVATH06262699 | 411 | D>Y | No | 1000Genomes | |
| tmp_3_17596900_G_C | 438 | L>V | No | 1000Genomes | |
| tmp_3_17596807_T_C | 469 | N>D | No | 1000Genomes | |
| ENSVATH00406263 | 471 | V>I | No | 1000Genomes | |
| tmp_3_17596670_G_T | 485 | P>H | No | 1000Genomes | |
| tmp_3_17596622_G_T | 501 | T>N | No | 1000Genomes | |
| tmp_3_17596620_A_T | 502 | L>I | No | 1000Genomes | |
| tmp_3_17596602_T_C | 508 | M>V | No | 1000Genomes | |
| ENSVATH02464223 | 514 | P>L | No | 1000Genomes | |
| tmp_3_17596532_G_A | 531 | T>M | No | 1000Genomes | |
| tmp_3_17596213_T_C | 573 | T>A | No | 1000Genomes | |
| ENSVATH06262686 | 637 | P>L | No | 1000Genomes | |
| ENSVATH06262683 | 661 | R>T | No | 1000Genomes | |
| tmp_3_17595581_C_T | 681 | G>S | No | 1000Genomes | |
| ENSVATH06262681 | 753 | R>S | No | 1000Genomes | |
| tmp_3_17595228_G_C | 770 | H>Q | No | 1000Genomes | |
| tmp_3_17595214_C_T | 775 | G>D | No | 1000Genomes | |
| tmp_3_17595212_A_T | 776 | S>T | No | 1000Genomes | |
| tmp_3_17595203_G_A | 779 | R>C | No | 1000Genomes | |
| ENSVATH06262677 | 793 | K>Q | No | 1000Genomes | |
| tmp_3_17595049_C_G,T | 799 | K>N | No | 1000Genomes | |
| tmp_3_17595036_A_C | 804 | F>V | No | 1000Genomes | |
| tmp_3_17594890_C_T | 827 | E>K | No | 1000Genomes | |
| tmp_3_17594785_T_C | 862 | M>V | No | 1000Genomes | |
| tmp_3_17594771_G_C | 866 | D>E | No | 1000Genomes | |
| tmp_3_17594650_T_C | 882 | I>V | No | 1000Genomes | |
| tmp_3_17594638_C_T | 886 | G>R | No | 1000Genomes | |
| ENSVATH12619120 | 890 | A>V | No | 1000Genomes | |
| ENSVATH06262673 | 892 | N>S | No | 1000Genomes | |
| ENSVATH06262672 | 894 | R>P | No | 1000Genomes | |
| ENSVATH00406255 | 896 | V>I | No | 1000Genomes | |
| tmp_3_17594530_G_A | 922 | P>S | No | 1000Genomes | |
| tmp_3_17594505_G_A | 930 | P>L | No | 1000Genomes | |
| ENSVATH00406254 | 938 | V>A | No | 1000Genomes | |
| tmp_3_17594463_C_G | 944 | R>T | No | 1000Genomes | |
| tmp_3_17594401_C_A | 965 | G>C | No | 1000Genomes | |
| ENSVATH12619119 | 972 | F>C | No | 1000Genomes | |
| tmp_3_17594376_G_T | 973 | S>Y | No | 1000Genomes | |
| ENSVATH06262669 | 976 | G>D | No | 1000Genomes | |
| tmp_3_17594368_C_G | 976 | G>R | No | 1000Genomes | |
| ENSVATH06262669 | 976 | G>V | No | 1000Genomes | |
| ENSVATH06262668 | 979 | R>Q | No | 1000Genomes | |
| tmp_3_17594346_G_C | 983 | S>W | No | 1000Genomes |
No associated diseases with Q84K47
5 regional properties for Q84K47
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ABC transporter-like, ATP-binding domain | 590 - 824 | IPR003439 |
| domain | AAA+ ATPase domain | 615 - 816 | IPR003593 |
| domain | ABC transporter type 1, transmembrane domain | 266 - 556 | IPR011527 |
| conserved_site | ABC transporter-like, conserved site | 727 - 741 | IPR017871 |
| domain | Mitochondrial ABC-transporter, N-terminal five TM domain | 6 - 255 | IPR032410 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ABC-type transporter activity | Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATPase-coupled transmembrane transporter activity | Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. |
| lipid transporter activity | Enables the directed movement of lipids into, out of or within a cell, or between cells. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| lipid transport | The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8WWZ4 | ABCA10 | ATP-binding cassette sub-family A member 10 | Homo sapiens (Human) | PR |
| Q8N139 | ABCA6 | ATP-binding cassette sub-family A member 6 | Homo sapiens (Human) | PR |
| Q8IUA7 | ABCA9 | ATP-binding cassette sub-family A member 9 | Homo sapiens (Human) | PR |
| P78363 | ABCA4 | Retinal-specific phospholipid-transporting ATPase ABCA4 | Homo sapiens (Human) | PR |
| Q8WWZ7 | ABCA5 | Cholesterol transporter ABCA5 | Homo sapiens (Human) | PR |
| Q86UK0 | ABCA12 | Glucosylceramide transporter ABCA12 | Homo sapiens (Human) | PR |
| Q8K449 | Abca9 | ATP-binding cassette sub-family A member 9 | Mus musculus (Mouse) | PR |
| Q8K448 | Abca5 | Cholesterol transporter ABCA5 | Mus musculus (Mouse) | PR |
| Q8K442 | Abca8a | ABC-type organic anion transporter ABCA8A | Mus musculus (Mouse) | PR |
| P34358 | ced-7 | ABC transporter ced-7 | Caenorhabditis elegans | PR |
| Q9FKF2 | ABCA11 | ABC transporter A family member 11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FLT5 | ABCA9 | ABC transporter A family member 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTLQRGLPLL | LQQYTALFKK | NLLLSWRSKR | ATFLQLFASF | FFILLIFCIQ | AAMEKSFASS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TALKTVTDPT | ALISPPIPPC | EDKFFVNLPC | YDFVWSGNRS | SKVTQIVNAI | MKNNPGRSIP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IEKVRSFVDP | EAVDTWLMAN | PLLVPGALHF | IERNATVISY | GIQTNSTPEM | NRGRFEDPTF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KFQIPLQIAA | EREIARSLIG | DPNFNWVVGF | KEFPHPTIEA | IVALDTIGPT | FFLAVAMFGF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VLQISSLITE | KELKLRQAMT | MMGVFDTAYW | LSWLTWEGIL | TAISALLTVL | FGMMFQFDFF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LKNSFPVVFL | LFMLFQFNLI | GLAFMLSAFI | SKSTSATTVG | FFVFLVGFVT | QLATSSGFPY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AKKYSRMIRA | LWSLFPPNTF | SQGLKLLADA | TSTPQDPGIS | WSKRAECGPN | DDTGCVLTIN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DIYLWLLGTF | FLWFVLALYF | DNITPNASGV | RKSIFYFLKP | GYWTGKGGNR | VEEGGICSCI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GSVPPVDHIT | PDDEDVLEEE | TLVKQHSMEG | LVDPNVAVQI | RGLAKTYPGT | TKFGCCKCKK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TSPFHALKGL | WMNIAKDQLF | CLLGPNGAGK | TTTINCLTGL | FPVTGGDALI | YGNSIRSSVG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| MSNIRKMIGV | CPQFDILWDA | LSGEEHLKLF | ASIKGLPPSS | INSMVEKSLA | EVKLTEAGKI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RAGSYSGGMK | RRLSVAVSLI | GDPKLVFLDE | PTTGMDPITR | RHVWDIIQET | KKGRAIILTT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| HSMEEADILS | DRIGIMAKGR | LRCIGTSIRL | KSRFGTGFIA | NISFVESNNH | NGEAGSDSRE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| PVKKFFKDHL | KVKPIEENKA | FMTFVIPHDK | ENLLTSFFAE | LQDREEEFGI | SDIQLGLATL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| EEVFLNIARK | AELESAAVDG | TMVTLDLTSG | SSVEIPVGAR | FIGIPGTETA | ENPRGVMVEV |
| 910 | 920 | 930 | 940 | 950 | 960 |
| YWQQDESGSL | CISGHSTEMP | IPENIPVTDP | VAPGHGGVNL | LGRRGRRQVQ | GIVIDPEFAT |
| 970 | 980 | ||||
| FTRSGSTSSR | RFSRSGSSRR | FSS |