Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P34358
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P34358-F1 | Predicted | AlphaFoldDB |
No variants for P34358
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P34358 | |||||
No associated diseases with P34358
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ABC-type transporter activity | Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATPase-coupled transmembrane transporter activity | Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. |
| lipid transporter activity | Enables the directed movement of lipids into, out of or within a cell, or between cells. |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process involved in development | Any apoptotic process that is involved in anatomical structure development. |
| establishment of mitotic spindle orientation | A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures. |
| left/right axis specification | The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes). |
| lipid transport | The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
| phospholipid efflux | The directed movement of a phospholipid out of a cell or organelle. |
| positive regulation of apoptotic process involved in development | Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development. |
| positive regulation of distal tip cell migration | Any process that activates or increases the frequency, rate or extent of distal tip cell migration. |
| positive regulation of engulfment of apoptotic cell | Any process that activates or increases the frequency, rate or extent of engulfment of apoptotic cell. |
| programmed cell death | A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8WWZ4 | ABCA10 | ATP-binding cassette sub-family A member 10 | Homo sapiens (Human) | PR |
| Q86UK0 | ABCA12 | Glucosylceramide transporter ABCA12 | Homo sapiens (Human) | PR |
| Q8N139 | ABCA6 | ATP-binding cassette sub-family A member 6 | Homo sapiens (Human) | PR |
| Q8IUA7 | ABCA9 | ATP-binding cassette sub-family A member 9 | Homo sapiens (Human) | PR |
| P78363 | ABCA4 | Retinal-specific phospholipid-transporting ATPase ABCA4 | Homo sapiens (Human) | PR |
| Q8WWZ7 | ABCA5 | Cholesterol transporter ABCA5 | Homo sapiens (Human) | PR |
| Q8K449 | Abca9 | ATP-binding cassette sub-family A member 9 | Mus musculus (Mouse) | PR |
| Q8K448 | Abca5 | Cholesterol transporter ABCA5 | Mus musculus (Mouse) | PR |
| Q8K442 | Abca8a | ABC-type organic anion transporter ABCA8A | Mus musculus (Mouse) | PR |
| Q84K47 | ABCA2 | ABC transporter A family member 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FKF2 | ABCA11 | ABC transporter A family member 11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FLT5 | ABCA9 | ABC transporter A family member 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNRLRQFSLL | LWKDWVLLRR | NKVWTLFELI | IPCLLLGPLV | YLVVKNADHT | SSPENIYDNF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QVKGTVEDVF | LESNFIKPIY | KRWCLRSDVV | VGYTSKDAAA | KRTVDDLMKK | FAERFQSAKL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KLSVKNESSE | EQLLTVLRND | LPMLNETFCA | INSYAAGVVF | DEVDVTNKKL | NYRILLGKTP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EETWHLTETS | YNPYGPSSGR | YSRIPSSPPY | WTSAFLTFQH | AIESSFLSSV | QSGAPDLPIT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LRGLPEPRYK | TSSVSAFIDF | FPFIWAFVTF | INVIHITREI | AAENHAVKPY | LTAMGLSTFM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FYAAHVVMAF | LKFFVIFLCS | IIPLTFVMEF | VSPAALIVTV | LMYGLGAVIF | GAFVASFFNN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TNSAIKAILV | AWGAMIGISY | KLRPELDQIS | SCFLYGLNIN | GAFALAVEAI | SDYMRREREL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NLTNMFNDSS | LHFSLGWALV | MMIVDILWMS | IGALVVDHIR | TSADFSLRTL | FDFEAPEDDE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NQTDGVTAQN | TRINEQVRNR | VRRSDMEIQM | NPMASTSLNP | PNADSDSLLE | GSTEADGARD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TARADIIVRN | LVKIWSTTGE | RAVDGLSLRA | VRGQCSILLG | HNGAGKSTTF | SSIAGIIRPT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NGRITICGYD | VGNEPGETRR | HIGMCPQYNP | LYDQLTVSEH | LKLVYGLKGA | REKDFKQDMK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RLLSDVKLDF | KENEKAVNLS | GGMKRKLCVC | MALIGDSEVV | LLDEPTAGMD | PGARQDVQKL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VEREKANRTI | LLTTHYMDEA | ERLGDWVFIM | SHGKLVASGT | NQYLKQKFGT | GYLLTVVLDH |
| 790 | 800 | 810 | 820 | 830 | 840 |
| NGDKRKMAVI | LTDVCTHYVK | EAERGEMHGQ | QIEIILPEAR | KKEFVPLFQA | LEAIQDRNYR |
| 850 | 860 | 870 | 880 | 890 | 900 |
| SNVFDNMPNT | LKSQLATLEM | RSFGLSLNTL | EQVFITIGDK | VDKAIASRQN | SRISHNSRNA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SEPSLKPAGY | DTQSSTKSAD | SYQKLMDSQA | RGPEKSGVAK | MVAQFISIMR | KKFLYSRRNW |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| AQLFTQVLIP | IILLGLVGSL | TTLKSNNTDQ | FSVRSLTPSG | IEPSKVVWRF | ENGTIPEEAA |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| NFEKILRKSG | GFEVLNYNTK | NPLPNITKSL | IGEMPPATIG | MTMNSDNLEA | LFNMRYYHVL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| PTLISMINRA | RLTGTVDAEI | SSGVFLYSKS | TSNSNLLPSQ | LIDVLLAPML | ILIFAMVTST |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| FVMFLIEERT | CQFAHQQFLT | GISPITFYSA | SLIYDGILYS | LICLIFLFMF | LAFHWMYDHL |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| AIVILFWFLY | FFSSVPFIYA | VSFLFQSPSK | ANVLLIIWQV | VISGAALLAV | FLIFMIFNID |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| EWLKSILVNI | FMFLLPSYAF | GSAIITINTY | GMILPSEELM | NWDHCGKNAW | LMGTFGVCSF |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| ALFVLLQFKF | VRRFLSQVWT | VRRSSHNNVQ | PMMGDLPVCE | SVSEERERVH | RVNSQNSALV |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| IKDLTKTFGR | FTAVNELCLA | VDQKECFGLL | GVNGAGKTTT | FNILTGQSFA | SSGEAMIGGR |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| DVTELISIGY | CPQFDALMLD | LTGRESLEIL | AQMHGFENYK | AKAELILECV | GMIAHADKLV |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| RFYSGGQKRK | ISVGVALLAP | TQMIILDEPT | AGIDPKARRE | VWELLLWCRE | HSNSALMLTS |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| HSMDECEALC | SRIAVLNRGS | LIAIGSSQEL | KSLYGNNYTM | TLSLYEPNQR | DMVVQLVQTR |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| LPNSVLKTTS | TNKTLNLKWQ | IPKEKEDCWS | AKFEMVQALA | KDLGVKDFIL | AQSSLEETFL |
| 1690 | 1700 | ||||
| RLAGLDEDQL | DTHSTVEISH | STHV |