Q9FFQ5

PR
Gene name
FLS3
Protein name
Flavonol synthase 3
Names
AtFLS3
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G63590
EC number
1.14.20.6: With 2-oxoglutarate as one donor, and the other dehydrogenated
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-127 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9FFQ5

Entry ID Method Resolution Chain Position Source
AF-Q9FFQ5-F1 Predicted AlphaFoldDB

40 variants for Q9FFQ5

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH07473463 2 E>Q No 1000Genomes
tmp_5_25458418_C_T 4 E>K No 1000Genomes
ENSVATH00749607 6 N>H No 1000Genomes
ENSVATH12918855 13 D>E No 1000Genomes
ENSVATH00749605 26 L>F No 1000Genomes
tmp_5_25458342_C_T 29 S>N No 1000Genomes
tmp_5_25458341_A_T 29 S>R No 1000Genomes
ENSVATH03470034 41 F>C No 1000Genomes
ENSVATH07473461 43 V>E No 1000Genomes
tmp_5_25458265_G_A 55 R>W No 1000Genomes
ENSVATH03470033 57 L>Q No 1000Genomes
ENSVATH03470032 58 Q>E No 1000Genomes
ENSVATH03470030 61 M>I No 1000Genomes
ENSVATH03470031 61 M>K No 1000Genomes
ENSVATH07473458 72 E>Q No 1000Genomes
ENSVATH00749603 78 E>D No 1000Genomes
tmp_5_25458088_C_T 114 V>I No 1000Genomes
tmp_5_25458075_A_C 118 F>C No 1000Genomes
tmp_5_25457913_T_A 130 N>I No 1000Genomes
tmp_5_25457838_C_T 155 R>K No 1000Genomes
ENSVATH00749598 156 H>L No 1000Genomes
ENSVATH00749598 156 H>R No 1000Genomes
ENSVATH07473448 178 P>L No 1000Genomes
ENSVATH03470025 183 P>L No 1000Genomes
ENSVATH03470024 184 E>D No 1000Genomes
ENSVATH07473446 189 A>D No 1000Genomes
ENSVATH00749596 192 H>N No 1000Genomes
tmp_5_25457694_G_A 203 A>V No 1000Genomes
ENSVATH14646899 208 G>E No 1000Genomes
ENSVATH14646900 208 G>R No 1000Genomes
ENSVATH12918831 211 A>T No 1000Genomes
ENSVATH00749594 214 D>A No 1000Genomes
tmp_5_25457635_T_G 223 T>P No 1000Genomes
tmp_5_25457632_T_A 224 T>S No 1000Genomes
ENSVATH00749593 267 S>F No 1000Genomes
tmp_5_25457288_G_T 271 Q>K No 1000Genomes
tmp_5_25457222_C_T 293 V>I No 1000Genomes
ENSVATH07473444 303 K>R No 1000Genomes
tmp_5_25457183_G_A 306 L>F No 1000Genomes
tmp_5_25457172_T_G 309 D>C No 1000Genomes

No associated diseases with Q9FFQ5

8 regional properties for Q9FFQ5

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 391 - 627 IPR003439-1
domain ABC transporter-like, ATP-binding domain 1033 - 1271 IPR003439-2
domain AAA+ ATPase domain 418 - 610 IPR003593-1
domain AAA+ ATPase domain 1060 - 1248 IPR003593-2
domain ABC transporter type 1, transmembrane domain 50 - 356 IPR011527-1
domain ABC transporter type 1, transmembrane domain 709 - 998 IPR011527-2
conserved_site ABC transporter-like, conserved site 530 - 544 IPR017871-1
conserved_site ABC transporter-like, conserved site 1174 - 1188 IPR017871-2

Functions

Description
EC Number 1.14.20.6 With 2-oxoglutarate as one donor, and the other dehydrogenated
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
dioxygenase activity Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf]
flavonol synthase activity Catalysis of the reaction: a dihydroflavonol + 2-oxoglurate + O2 = a flavonol + succinate + CO2 + H2O.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton.
response to light stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P41213 A2 Leucoanthocyanidin dioxygenase Zea mays (Maize) PR
Q8H1S4 At1g06650 1-aminocyclopropane-1-carboxylate oxidase homolog 3 Arabidopsis thaliana (Mouse-ear cress) PR
F4KAS1 FLS4 Probable flavonol synthase 4 Arabidopsis thaliana (Mouse-ear cress) PR
Q0WPW4 At1g77330 1-aminocyclopropane-1-carboxylate oxidase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q96330 FLS1 Flavonol synthase/flavanone 3-hydroxylase Arabidopsis thaliana (Mouse-ear cress) PR
Q9C899 F6'H2 Feruloyl CoA ortho-hydroxylase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FZ21 GA2OX6 Gibberellin 2-beta-dioxygenase 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZTA3 AOP1 Probable 2-oxoglutarate-dependent dioxygenase AOP1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZUN4 ACO1 1-aminocyclopropane-1-carboxylate oxidase 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEMEKNQHIS SLDIPVIDLS NPDEELVASA VVKASQEWGI FQVVNHGIPT ELILRLLQVG
70 80 90 100 110 120
MEFFELPETE KEAVAKPEDS LDIEGYRTKY QKDLEGRNAW VDHLFHRIWP PSRVNHKFWP
130 140 150 160 170 180
KNPPEYIEVN EEYASHIKKL SEKIMEWLSE GLGLRHEALK EGLGGETIEY LMKINYYPPC
190 200 210 220 230 240
PDPELVVGAP DHTDVNGITL LVANEALGLQ AFKDNQWIDA EYTTSGIIVI IGDQFLRMSN
250 260 270 280 290 300
GKYKSVEHRA KMDKEKTRIS WPVFVESSLD QVFGPLPELI TGDENVPKFK PYVYKDYKFR
KLKKLLLD