F4KAS1

PR
Gene name
FLS4 (At5g63595, MBK5)
Protein name
Probable flavonol synthase 4
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G63595
EC number
1.14.20.6: With 2-oxoglutarate as one donor, and the other dehydrogenated
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-128 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for F4KAS1

Entry ID Method Resolution Chain Position Source
AF-F4KAS1-F1 Predicted AlphaFoldDB

52 variants for F4KAS1

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH07473494 10 P>A No 1000Genomes
tmp_5_25460358_C_G 27 V>L No 1000Genomes
ENSVATH14646909 29 D>G No 1000Genomes
ENSVATH07473493 29 D>N No 1000Genomes
ENSVATH12918962 38 V>L No 1000Genomes
ENSVATH03470077 49 W>* No 1000Genomes
tmp_5_25460284_A_C 51 I>M No 1000Genomes
tmp_5_25460250_G_C 63 L>V No 1000Genomes
ENSVATH00749629 66 R>K No 1000Genomes
ENSVATH03470076 68 H>Q No 1000Genomes
ENSVATH12918961 72 T>K No 1000Genomes
ENSVATH00749628 77 L>I No 1000Genomes
tmp_5_25460207_A_G 77 L>P No 1000Genomes
ENSVATH03470075 80 S>P No 1000Genomes
ENSVATH03470074 83 E>* No 1000Genomes
ENSVATH07473490 96 G>R No 1000Genomes
tmp_5_25460146_A_C 97 Y>* No 1000Genomes
tmp_5_25460135_T_C 101 D>G No 1000Genomes
ENSVATH00749627 102 V>I No 1000Genomes
tmp_5_25460113_A_T 108 H>Q No 1000Genomes
ENSVATH12918960 108 H>Y No 1000Genomes
ENSVATH03470073 124 W>G No 1000Genomes
ENSVATH03470072 125 P>S No 1000Genomes
ENSVATH03470071 127 N>S No 1000Genomes
ENSVATH12918959 132 R>G No 1000Genomes
ENSVATH00749625 137 E>K No 1000Genomes
ENSVATH03470068 141 H>Q No 1000Genomes
tmp_5_25459833_C_T 142 A>T No 1000Genomes
tmp_5_25459820_G_A 146 A>V No 1000Genomes
ENSVATH12918925 161 M>T No 1000Genomes
ENSVATH12918914 162 K>Q No 1000Genomes
ENSVATH00749623 172 P>L No 1000Genomes
ENSVATH07473480 173 D>N No 1000Genomes
ENSVATH00749622 174 W>* No 1000Genomes
ENSVATH03470067 184 F>I No 1000Genomes
tmp_5_25459649_C_A 186 G>* No 1000Genomes
ENSVATH00749621 186 G>E No 1000Genomes
ENSVATH03470066 192 P>L No 1000Genomes
ENSVATH00749620 193 N>I No 1000Genomes
tmp_5_25459597_T_C 203 E>G No 1000Genomes
tmp_5_25459592_G_A 205 R>C No 1000Genomes
tmp_5_25459579_A_T 209 V>E No 1000Genomes
ENSVATH03470065 210 D>E No 1000Genomes
ENSVATH00749618 216 V>L No 1000Genomes
tmp_5_25459404_C_A 231 R>M No 1000Genomes
ENSVATH12918910 237 H>Q No 1000Genomes
ENSVATH00749617 239 A>T No 1000Genomes
tmp_5_25459336_T_C 254 I>V No 1000Genomes
ENSVATH03470058 264 H>L No 1000Genomes
ENSVATH03470057 268 S>T No 1000Genomes
ENSVATH03470056 271 A>T No 1000Genomes
ENSVATH00749616 272 I>T No 1000Genomes

No associated diseases with F4KAS1

3 regional properties for F4KAS1

Type Name Position InterPro Accession
domain Oxoglutarate/iron-dependent dioxygenase 156 - 256 IPR005123
domain Non-haem dioxygenase N-terminal domain 26 - 99 IPR026992
domain Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain 161 - 253 IPR044861

Functions

Description
EC Number 1.14.20.6 With 2-oxoglutarate as one donor, and the other dehydrogenated
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
dioxygenase activity Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf]
flavonol synthase activity Catalysis of the reaction: a dihydroflavonol + 2-oxoglurate + O2 = a flavonol + succinate + CO2 + H2O.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
response to light stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P41213 A2 Leucoanthocyanidin dioxygenase Zea mays (Maize) PR
Q8H1S4 At1g06650 1-aminocyclopropane-1-carboxylate oxidase homolog 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q0WPW4 At1g77330 1-aminocyclopropane-1-carboxylate oxidase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q96330 FLS1 Flavonol synthase/flavanone 3-hydroxylase Arabidopsis thaliana (Mouse-ear cress) PR
Q9C899 F6'H2 Feruloyl CoA ortho-hydroxylase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FFQ5 FLS3 Flavonol synthase 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FZ21 GA2OX6 Gibberellin 2-beta-dioxygenase 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZTA3 AOP1 Probable 2-oxoglutarate-dependent dioxygenase AOP1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZUN4 ACO1 1-aminocyclopropane-1-carboxylate oxidase 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEVERDQHKP PLSLQNNKIP SSQNFPVVDL SNTNGELVAR KVAKASEEWG IFQVVNHGIP
70 80 90 100 110 120
TELIRRLHKV DTQFFELPES KKEAVAKPAN SKEIQGYEMD DVQGRRSHIF HNLYPSSSVN
130 140 150 160 170 180
YAFWPKNPPE YREVTEEFAK HAKQLAEEIL GLLSEGAGYL MKINYYRPCP EPDWVMGIKA
190 200 210 220 230 240
HTDFNGLTLL IPNEIFGLQV FKEDRWLDVD YIYPAVIIII GDQIMKMSNG RYNNVLHRAL
250 260 270
MDKKKTRMSS VVHIKPPYDM VVSHFPNSPA AIILPSSSL