Q9FFN7

PR
Gene name
DGK2
Protein name
Diacylglycerol kinase 2
Names
AtDGK2, DAG kinase 2, Diglyceride kinase 2, DGK 2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G63770
EC number
2.7.1.107: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

216-350 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9FFN7

Entry ID Method Resolution Chain Position Source
AF-Q9FFN7-F1 Predicted AlphaFoldDB

32 variants for Q9FFN7

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_5_25519348_G_A 19 S>N No 1000Genomes
tmp_5_25519361_T_A 23 F>L No 1000Genomes
tmp_5_25519392_C_A 34 L>M No 1000Genomes
tmp_5_25519497_C_T 69 P>S No 1000Genomes
ENSVATH00749874 83 Q>P No 1000Genomes
ENSVATH12920767 103 N>S No 1000Genomes
ENSVATH00749875 115 A>T No 1000Genomes
ENSVATH00749876 154 N>S No 1000Genomes
tmp_5_25519773_A_C 161 M>L No 1000Genomes
ENSVATH07474420 198 M>I No 1000Genomes
tmp_5_25519956_C_T 222 H>Y No 1000Genomes
ENSVATH03471142 267 K>N No 1000Genomes
tmp_5_25520125_A_G 278 K>R No 1000Genomes
tmp_5_25520196_T_G 302 S>A No 1000Genomes
ENSVATH07474422 304 M>I No 1000Genomes
ENSVATH03471143 328 M>V No 1000Genomes
ENSVATH07474424 333 L>F No 1000Genomes
ENSVATH03471144 336 L>F No 1000Genomes
tmp_5_25520316_C_T 342 P>S No 1000Genomes
tmp_5_25520500_C_T 377 S>F No 1000Genomes
ENSVATH00749877 382 D>Y No 1000Genomes
ENSVATH03471145 391 V>M No 1000Genomes
ENSVATH07474428 415 R>H No 1000Genomes
tmp_5_25520631_C_T 421 P>S No 1000Genomes
ENSVATH12920771 449 G>E No 1000Genomes
ENSVATH03471147 477 E>D No 1000Genomes
tmp_5_25521008_C_G 522 Q>E No 1000Genomes
tmp_5_25521288_C_A 557 D>E No 1000Genomes
tmp_5_25521684_G_C 573 G>A No 1000Genomes
ENSVATH14647176 578 G>* No 1000Genomes
ENSVATH07474442 587 E>D No 1000Genomes
tmp_5_25521728_C_T 588 H>Y No 1000Genomes

No associated diseases with Q9FFN7

4 regional properties for Q9FFN7

Type Name Position InterPro Accession
domain Diacylglycerol kinase, accessory domain 491 - 648 IPR000756
domain Diacylglycerol kinase, catalytic domain 338 - 479 IPR001206
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 72 - 133 IPR002219-1
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 145 - 208 IPR002219-2

Functions

Description
EC Number 2.7.1.107 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
diacylglycerol kinase activity Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate.
metal ion binding Binding to a metal ion.

7 GO annotations of biological process

Name Definition
defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
leaf development The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
protein kinase C-activating G protein-coupled receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).
response to cold Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
response to wounding Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
root development The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P52429 DGKE Diacylglycerol kinase epsilon Homo sapiens (Human) PR
Q86XP1 DGKH Diacylglycerol kinase eta Homo sapiens (Human) PR
Q5KSL6 DGKK Diacylglycerol kinase kappa Homo sapiens (Human) PR
Q6P5E8 Dgkq Diacylglycerol kinase theta Mus musculus (Mouse) PR
O88673 Dgka Diacylglycerol kinase alpha Mus musculus (Mouse) PR
Q91WG7 Dgkg Diacylglycerol kinase gamma Mus musculus (Mouse) PR
P20192 DGKA Diacylglycerol kinase alpha Sus scrofa (Pig) PR
P49620 Dgkg Diacylglycerol kinase gamma Rattus norvegicus (Rat) PR
P51556 Dgka Diacylglycerol kinase alpha Rattus norvegicus (Rat) PR
Q8VZG1 DGK3 Diacylglycerol kinase 3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MMEVGFSLIQ WLISSGADSP FIFGWLVTGS VGLLAVIYTF LKWQKKTSLN WVKAAAREKK
70 80 90 100 110 120
KVWKRLRVPL SHHQWTDDYG YGQQPSTCCV CLYSLVPGQN VSNKASLSIP VHRCAVCGVA
130 140 150 160 170 180
AHFYCSSSAA KDCKCVAQAG SDHVRHHWSE RWVNMDDNAD MTAFCFYCDE PCGIPFIEAS
190 200 210 220 230 240
PMWHCLWCQR LIHVKCHMIM SKESGDACDL GSLRRVILSP VHVKLNEANG VDGVLTTIKN
250 260 270 280 290 300
ELASIRGHVR RKRHRGKNGN GQSLNGKLLE DSVSDPVKTV VNGLVVKKLR RDRSIDCLKQ
310 320 330 340 350 360
VSDMPNAKGL QNGIGGHKRN KSAALNFMKK FSLVDLPPDA RPLLVFINAK SGGQLGPFLH
370 380 390 400 410 420
RRLNMLLNPV QVFELGSCQG PDAGLDLCSK VKYFRVLVCG GDGTVAWVLD AIEKRNFESP
430 440 450 460 470 480
PPVAILPLGT GNDLSRVLQW GRGISVVDGQ GSLRTFLQDI DHAAVTMLDR WSVKIVEEST
490 500 510 520 530 540
EKFPAREGHK FMMNYLGIGC DAKVAYEFHM MRQEKPEKFC SQFVNKLRYA KEGARDIMDR
550 560 570 580 590 600
ACADLPWQVW LEVDGKDIEI PKDSEGLIVL NIGSYMGGVD LWQNDYEHDD NFSIQCMHDK
610 620 630 640 650 660
TLEVVCVRGA WHLGKLQVGL SQARRLAQGK VIRIHVSSPF PVQIDGEPFI QQPGCLEITH
670 680 690 700 710
HGQVFMLRRA SDEPRGHAAA IMNEVLLDAE CKGVINASQK KVLLQQMALH LS