P51556

PR
Gene name
Dgka (Dagk, Dagk1)
Protein name
Diacylglycerol kinase alpha
Names
DAG kinase alpha, 80 kDa diacylglycerol kinase, Diglyceride kinase alpha, DGK-alpha
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:140866
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

315-385 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P51556

Entry ID Method Resolution Chain Position Source
AF-P51556-F1 Predicted AlphaFoldDB

No variants for P51556

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P51556

No associated diseases with P51556

2 regional properties for P51556

Type Name Position InterPro Accession
domain Dynein regulatory complex protein 1, C-terminal 660 - 719 IPR029440
domain Dynein regulatory complex protein 1/2, N-terminal 100 - 200 IPR039505

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calcium ion binding Binding to a calcium ion (Ca2+).
diacylglycerol kinase activity Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
lipid binding Binding to a lipid.
phospholipid binding Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.

6 GO annotations of biological process

Name Definition
diacylglycerol metabolic process The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.
glycerolipid metabolic process The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
lipid phosphorylation The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.
phosphatidic acid biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
protein kinase C-activating G protein-coupled receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P52429 DGKE Diacylglycerol kinase epsilon Homo sapiens (Human) PR
Q6P5E8 Dgkq Diacylglycerol kinase theta Mus musculus (Mouse) PR
Q91WG7 Dgkg Diacylglycerol kinase gamma Mus musculus (Mouse) PR
O88673 Dgka Diacylglycerol kinase alpha Mus musculus (Mouse) PR
P20192 DGKA Diacylglycerol kinase alpha Sus scrofa (Pig) PR
P49620 Dgkg Diacylglycerol kinase gamma Rattus norvegicus (Rat) PR
Q8VZG1 DGK3 Diacylglycerol kinase 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FFN7 DGK2 Diacylglycerol kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAKDKGLISP EDFAQLQKYI DYSTKSVSDV LKVFEMNKYC QGDEIGYLGF EQFLKMYLEV
70 80 90 100 110 120
EEVPHHLCWT LFWSFHSSQD LDEETESKAN VICLSDVYCY FTLLEGGSPE DKLEFTFKLY
130 140 150 160 170 180
DMDRNGILDS TEVEKIILQM MRVAEYLDWD VSELRPILQE MMKEMDRDGS GCVSLAEWVR
190 200 210 220 230 240
AGATTVPLLV LLGIDMTMKD DGHHIWRPKR FSRPVYCNLC ELSIGLGKQG LSCNLCKYIV
250 260 270 280 290 300
HDHCAMKAQP CEVSTYAKSR KDIGVQPHVW VRGGCHSGRC DRCQKKIRTY HSLTGLHCVW
310 320 330 340 350 360
CHLEIHDDCL QAVGPECDCG LLRDHILPPC SIYPRVLVSG QECKQKTTDV TSLCTPEAFR
370 380 390 400 410 420
IEPVSNTHPL LVFINPKSGG KQGQSVLWKF QYILNPRQVF NLKDGPEPGL RFFKDVPQFR
430 440 450 460 470 480
VLVCGGDGTV GWILETIDKA NFPIVPPVAV LPLGTGNDLA RCLRWGRGYE GENLRKILKD
490 500 510 520 530 540
IEISKVVYLD RWLLEVIPQQ NGEKSDPVPS QIINNYFSIG VDASIAHRFH LMREKYPEKF
550 560 570 580 590 600
NSRMKNKLWY LEFATSESIF STCKKLEESV TVEICGKLLD LSDLSLEGIA VLNIPSMHGG
610 620 630 640 650 660
SNLWGDTKRP HGDTCGINQA LGSVAKIITD PDILKTCVPD MSDKRLEVVG IEGVIEMGQI
670 680 690 700 710 720
YTRLKSAGHR LAKCSEITFQ TTKTLPMQVD GEPWMQAPCT IKITHKNQMP MLMGPAPSSS
NFFGFWS