Q8VZG1

PR
Gene name
DGK3 (At2g18730, MSF3.11)
Protein name
Diacylglycerol kinase 3
Names
AtDGK3, DAG kinase 3, Diglyceride kinase 3, DGK 3
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G18730
EC number
2.7.1.107: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-56 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8VZG1

Entry ID Method Resolution Chain Position Source
AF-Q8VZG1-F1 Predicted AlphaFoldDB

16 variants for Q8VZG1

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_2_8119055_C_T 27 T>M No 1000Genomes
ENSVATH14517170 39 V>I No 1000Genomes
ENSVATH13267786 80 G>C No 1000Genomes
tmp_2_8119225_G_T 84 A>S No 1000Genomes
ENSVATH14517171 84 A>V No 1000Genomes
tmp_2_8119702_G_C 136 G>A No 1000Genomes
tmp_2_8119930_G_C 182 D>H No 1000Genomes
tmp_2_8120110_C_G 214 A>G No 1000Genomes
ENSVATH13267812 257 P>S No 1000Genomes
ENSVATH05527409 258 A>S No 1000Genomes
ENSVATH05527409 258 A>T No 1000Genomes
tmp_2_8120507_A_G 281 E>G No 1000Genomes
ENSVATH01839446 323 S>G No 1000Genomes
ENSVATH00237300 364 A>P No 1000Genomes
ENSVATH00237303 393 D>E No 1000Genomes
ENSVATH00237307 412 I>V No 1000Genomes

No associated diseases with Q8VZG1

2 regional properties for Q8VZG1

Type Name Position InterPro Accession
domain Diacylglycerol kinase, accessory domain 283 - 460 IPR000756
domain Diacylglycerol kinase, catalytic domain 87 - 245 IPR001206

Functions

Description
EC Number 2.7.1.107 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasmodesma A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
diacylglycerol kinase activity Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate.

3 GO annotations of biological process

Name Definition
defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
protein kinase C-activating G protein-coupled receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P52429 DGKE Diacylglycerol kinase epsilon Homo sapiens (Human) PR
O88673 Dgka Diacylglycerol kinase alpha Mus musculus (Mouse) PR
Q6P5E8 Dgkq Diacylglycerol kinase theta Mus musculus (Mouse) PR
Q91WG7 Dgkg Diacylglycerol kinase gamma Mus musculus (Mouse) PR
P20192 DGKA Diacylglycerol kinase alpha Sus scrofa (Pig) PR
P49620 Dgkg Diacylglycerol kinase gamma Rattus norvegicus (Rat) PR
P51556 Dgka Diacylglycerol kinase alpha Rattus norvegicus (Rat) PR
Q9FFN7 DGK2 Diacylglycerol kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MDSPVSKTDA SKEKFVASRP STADSKTMRG CGLANLAWVG VDKVELRQRL MMPEYLRLAM
70 80 90 100 110 120
RDCIKRKDSS AIPDHLLLPG GAVADMAPHA PMVVFINPNS GGRHGPVLKE RLQQLMSEEQ
130 140 150 160 170 180
VFDLTEVKPH EFVRYGLGCL EKVAAEGDEC AKECRARLRI MVAGGDGTVG WVLGCLGELN
190 200 210 220 230 240
KDGKSQIPPV GVIPLGTGND LSRSFGWGGS FPFAWRSAVK RTLHRASMGP VARLDSWKIL
250 260 270 280 290 300
VSMPSGEVVD PPYSLKPAEE NELDQGLDAG IDAPPLAKAY EGVFYNYLSI GMDAQVAYGF
310 320 330 340 350 360
HHLRNTKPYL AQGPISNKII YSSFGCSQGW FCTPCVNDPG LRGLRNIMKI HIKKVNCSQW
370 380 390 400 410 420
EEIAVPKNVR SIVALNLHSY GSGSHPWGNL KPDYLEKRGF VEAHCDDGLI EIFGFKQGWH
430 440 450 460 470 480
ASFVMAELIS AKHIAQAAAV RFELRGGDWR DAFLQMDGEP WKQPMSTEYS TFVEIKKVPY
QSLMINNE