P20192

PR
Gene name
DGKA (DAGK, DAGK1)
Protein name
Diacylglycerol kinase alpha
Names
DAG kinase alpha, 80 kDa diacylglycerol kinase, Diglyceride kinase alpha, DGK-alpha
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:397097
EC number
2.7.1.93: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

311-393 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P20192

Entry ID Method Resolution Chain Position Source
AF-P20192-F1 Predicted AlphaFoldDB

No variants for P20192

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P20192

No associated diseases with P20192

9 regional properties for P20192

Type Name Position InterPro Accession
domain Diacylglycerol kinase, accessory domain 519 - 700 IPR000756
domain Diacylglycerol kinase, catalytic domain 371 - 505 IPR001206
domain EF-hand domain 109 - 189 IPR002048
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 204 - 253 IPR002219-1
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 267 - 320 IPR002219-2
binding_site EF-Hand 1, calcium-binding site 122 - 134 IPR018247-1
binding_site EF-Hand 1, calcium-binding site 167 - 179 IPR018247-2
domain Diacylglycerol kinase type I, N-terminal 6 - 88 IPR029477
domain Diacylglycerol kinase alpha, second protein kinase C conserved region 1 269 - 330 IPR047469

Functions

Description
EC Number 2.7.1.93 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calcium ion binding Binding to a calcium ion (Ca2+).
diacylglycerol kinase activity Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate.

5 GO annotations of biological process

Name Definition
diacylglycerol metabolic process The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
lipid phosphorylation The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.
phosphatidic acid biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
protein kinase C-activating G protein-coupled receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P52429 DGKE Diacylglycerol kinase epsilon Homo sapiens (Human) PR
Q6P5E8 Dgkq Diacylglycerol kinase theta Mus musculus (Mouse) PR
Q91WG7 Dgkg Diacylglycerol kinase gamma Mus musculus (Mouse) PR
O88673 Dgka Diacylglycerol kinase alpha Mus musculus (Mouse) PR
P49620 Dgkg Diacylglycerol kinase gamma Rattus norvegicus (Rat) PR
P51556 Dgka Diacylglycerol kinase alpha Rattus norvegicus (Rat) PR
Q8VZG1 DGK3 Diacylglycerol kinase 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FFN7 DGK2 Diacylglycerol kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSKERGLISP SDFAQLQKYM EYSTKKVSDV LKLFEDGEMA EYLQGDAIGY EGFQQFLKIY
70 80 90 100 110 120
LEVDSVPSHL SLALFQSFQT SYCSEETVKR DVVCLSDVSC YFSLLEGGRP EDKLEFTFKL
130 140 150 160 170 180
YDTDRNGILD SSEVDRIIIQ MMRMAEYLDW DVSELRPILQ EMMKEIDYDG SGSVSLAEWL
190 200 210 220 230 240
RAGATTVPLL VLLGLEMTLK DNGQHMWRPK RFPRPVYCNL CESSIGLGKQ GLSCNLCKYT
250 260 270 280 290 300
VHDQCAMKAL PCEVSTYAKS RKDIGVQTHV WVRGGCESGR CDRCQKKIRI YHSLVGLHCV
310 320 330 340 350 360
WCHLEIHDDC LPAMGHECDC GLLRDHILPP SSIYPSVLAS GQERKVSKTS QKTTDDLNLS
370 380 390 400 410 420
TSEALRIDPV SNTHPLLVFV NPKSGGKQGE RVLWKFQYLL NPRQVFNLLK DGPEPGLRFF
430 440 450 460 470 480
REVPDYRILV CGGDGTVGWI LETIDKANLP FVPPVAVLPL GTGNDLARCL RWGGGYEGQN
490 500 510 520 530 540
LGKILKDLEA SKVVHMDRWS VEVIPQQTEE KSDPVPFQII NNYFSIGVDA SIAHRFHIMR
550 560 570 580 590 600
EKYPEKFNSR MKNKLWYFEF ATSESIFSTC KKLEESLTVE ICGKPLDLSN LSLEGIAVLN
610 620 630 640 650 660
IPSTHGGSNL WGDTKRPHGD IHGINQALGA MAKVITDPDI LKTCVPDLSD KRLEVVGLEG
670 680 690 700 710 720
AIEMGQIYTK LKNAGHRLAK CSEITFHTTK TLPMQIDGEP WMQTPCTIKI THRNQMPMLV
730
GPPPRSSNFF GFLC