Q91WG7
PR
Gene name |
Dgkg (Dagk3) |
Protein name |
Diacylglycerol kinase gamma |
Names |
DAG kinase gamma, 88 kDa diacylglycerol kinase, Diglyceride kinase gamma, DGK-gamma |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:110197 |
EC number |
2.7.1.107: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q91WG7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q91WG7-F1 | Predicted | AlphaFoldDB |
38 variants for Q91WG7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389405297 | 10 | S>L | No | EVA | |
| rs3389405320 | 35 | F>I | No | EVA | |
| rs241965630 | 39 | G>E | No | EVA | |
| rs48513924 | 42 | R>K | No | EVA | |
| rs225228128 | 87 | T>I | No | EVA | |
| rs1134699934 | 96 | S>N | No | EVA | |
| rs50253137 | 100 | P>H | No | EVA | |
| rs49254216 | 102 | V>I | No | EVA | |
| rs3389424647 | 110 | A>D | No | EVA | |
| rs50788007 | 151 | S>L | No | EVA | |
| rs49277872 | 170 | T>S | No | EVA | |
| rs3389402766 | 244 | N>K | No | EVA | |
| rs3389368902 | 254 | V>SDG* | No | EVA | |
| rs3389378040 | 278 | K>Q | No | EVA | |
| rs3406664300 | 303 | K>I | No | EVA | |
| rs3406162883 | 304 | Y>F | No | EVA | |
| rs3389402496 | 324 | K>N | No | EVA | |
| rs3389405662 | 336 | W>G | No | EVA | |
| rs3389408178 | 344 | K>N | No | EVA | |
| rs3389419272 | 391 | L>Q | No | EVA | |
| rs3389377095 | 442 | G>* | No | EVA | |
| rs3406689725 | 482 | F>S | No | EVA | |
| rs3406755170 | 483 | R>H | No | EVA | |
| rs3406801000 | 484 | V>L | No | EVA | |
| rs3406824235 | 487 | C>* | No | EVA | |
| rs3405084321 | 487 | C>S | No | EVA | |
| rs3406583759 | 487 | C>S | No | EVA | |
| rs3406583810 | 489 | G>E | No | EVA | |
| rs3389414671 | 501 | D>N | No | EVA | |
| rs3389388007 | 511 | V>M | No | EVA | |
| rs3389408189 | 515 | P>H | No | EVA | |
| rs3389399461 | 529 | G>E | No | EVA | |
| rs1131854545 | 585 | D>V | No | EVA | |
| rs3389324538 | 625 | T>S | No | EVA | |
| rs3389402779 | 632 | H>Q | No | EVA | |
| rs3389377174 | 681 | R>K | No | EVA | |
| rs3389405671 | 729 | Q>* | No | EVA | |
| rs3389399489 | 789 | D>L | No | EVA |
No associated diseases with Q91WG7
6 regional properties for Q91WG7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Coagulation factor 5/8 C-terminal domain | 272 - 422 | IPR000421-1 |
| domain | Coagulation factor 5/8 C-terminal domain | 428 - 581 | IPR000421-2 |
| domain | CUB domain | 25 - 139 | IPR000859-1 |
| domain | CUB domain | 145 - 263 | IPR000859-2 |
| domain | MAM domain | 639 - 811 | IPR000998 |
| domain | Neuropilin, C-terminal | 847 - 923 | IPR022579 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.107 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| diacylglycerol kinase activity | Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate. |
| lipid binding | Binding to a lipid. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| diacylglycerol metabolic process | The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. |
| glycerolipid metabolic process | The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| lipid phosphorylation | The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. |
| negative regulation of protein kinase C signaling | Any process that decreases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. |
| neuron development | The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. |
| phosphatidic acid biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. |
| protein kinase C-activating G protein-coupled receptor signaling pathway | The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG). |
| regulation of dendrite development | Any process that modulates the frequency, rate or extent of dendrite development. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P52429 | DGKE | Diacylglycerol kinase epsilon | Homo sapiens (Human) | PR |
| O88673 | Dgka | Diacylglycerol kinase alpha | Mus musculus (Mouse) | PR |
| Q6P5E8 | Dgkq | Diacylglycerol kinase theta | Mus musculus (Mouse) | PR |
| P20192 | DGKA | Diacylglycerol kinase alpha | Sus scrofa (Pig) | PR |
| P51556 | Dgka | Diacylglycerol kinase alpha | Rattus norvegicus (Rat) | PR |
| P49620 | Dgkg | Diacylglycerol kinase gamma | Rattus norvegicus (Rat) | PR |
| Q8VZG1 | DGK3 | Diacylglycerol kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FFN7 | DGK2 | Diacylglycerol kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSEEQWVSLS | SEEFDQLQKY | SEYSSKKIKD | VLAEFNEGGS | LRQYDPHKPI | SYDVFKLFMR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AYLEVDLPQP | LSTHLFLAFS | QKPRQETPDH | PKEGASSSEP | NVSDYNSDNA | AKADEACAPD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TESKTTKTQA | PSKELEAAAP | WEDPGALASS | SDAPVVYLKD | VVCYLSLMET | GRPQDKLEFM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FRLYDSDENG | LLDQAEMDQI | VSQMLHVAQY | LEWDPTELRP | ILKEMLQGMD | YDKDGFVSLQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EWINGGMTTI | PLLVLLGMDD | SGSKGDGRHA | WTLKHFKKPT | YCNFCRAMLM | GVGKQGLCCI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YCKYTVHQRC | VSKTIHGCVK | TNSKAKRSGE | VMQHAWVEGN | SSVKCDRCHK | SIKCYQSVTA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RHCVWCRMTF | HRKCELSTVC | DGGELKDHIL | LPTSICPVSG | DRQGGKSDGS | VAAKGELVTQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YKIIPSPGTH | PLLVLVNPKS | GGRQGERILR | KFHYLLNPEQ | VFNLDNGGPT | PGLNFFHDTP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DFRVLACGGD | GTVGWILDCI | DKANFTKHPP | VAVLPLGTGN | DLARCLRWGG | GYEGGSLTKI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LKEIEQSPLV | MLDRWYLEVM | PREEVENGDQ | VPYNIMNNYF | SIGVDASIAH | RFHMMREKHP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EKFNSRMKNK | LWYFEFGTSE | TFAATCKKLH | DHIELECDGV | EVDLSNIFLE | GIAILNIPSM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YGGTNLWGET | KKNRAVIRES | RKSVTDPKEL | KCCVQDLSDQ | LLEVVGLEGA | MEMGQIYTGL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KSAGRRLAQC | SSVTIRTNKL | LPMQVDGEPW | MQPQCTIKIT | HKNQAPMMMG | PPQKSSFFSL |
| RRKSRSKD |