P49620

PR
Gene name
Dgkg (Dagk3)
Protein name
Diacylglycerol kinase gamma
Names
DAG kinase gamma, 88 kDa diacylglycerol kinase, DGK-III, Diglyceride kinase gamma, DGK-gamma
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:25666
EC number
2.7.1.107: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

55-152 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P49620

Entry ID Method Resolution Chain Position Source
AF-P49620-F1 Predicted AlphaFoldDB

No variants for P49620

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P49620

No associated diseases with P49620

2 regional properties for P49620

Type Name Position InterPro Accession
domain Dynein regulatory complex protein 1, C-terminal 660 - 719 IPR029440
domain Dynein regulatory complex protein 1/2, N-terminal 100 - 200 IPR039505

Functions

Description
EC Number 2.7.1.107 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Membrane
  • Cytoplasm, cytosol
  • Cytoplasm, cytoskeleton
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calcium ion binding Binding to a calcium ion (Ca2+).
diacylglycerol kinase activity Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate.
lipid binding Binding to a lipid.

9 GO annotations of biological process

Name Definition
diacylglycerol metabolic process The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.
glycerolipid metabolic process The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
lipid phosphorylation The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.
negative regulation of protein kinase C signaling Any process that decreases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
neuron development The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
phosphatidic acid biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
protein kinase C-activating G protein-coupled receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).
regulation of dendrite development Any process that modulates the frequency, rate or extent of dendrite development.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P52429 DGKE Diacylglycerol kinase epsilon Homo sapiens (Human) PR
O88673 Dgka Diacylglycerol kinase alpha Mus musculus (Mouse) PR
Q6P5E8 Dgkq Diacylglycerol kinase theta Mus musculus (Mouse) PR
Q91WG7 Dgkg Diacylglycerol kinase gamma Mus musculus (Mouse) PR
P20192 DGKA Diacylglycerol kinase alpha Sus scrofa (Pig) PR
P51556 Dgka Diacylglycerol kinase alpha Rattus norvegicus (Rat) PR
Q8VZG1 DGK3 Diacylglycerol kinase 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FFN7 DGK2 Diacylglycerol kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSDGQWVCLS SEEFDQLQKY SEYSSKKIKD VLAEFNEGGS LKQYDPHKPI SYDVFKLFMR
70 80 90 100 110 120
AYLEVDLPQP LSTNLFLAFS QKPRQETPDH PKEGASSSEP NVSDSNAEST AKADAACAPD
130 140 150 160 170 180
TESKPIKTQV PSEELEAAAP WGEPNAPASS SDAPIVYLKD VVCYLSLMET GRPQDKLEFM
190 200 210 220 230 240
FRLYDSDENE LLDQAELDQI VSQMLHVAQY LEWDPTELRP ILKEMLQGMD YNKDGFVSLE
250 260 270 280 290 300
EWVSGGMTTI PLLVLLGMDD SASKGDGRHA WTLKHFKKPT YCNFCHIMLM GVRKQGLCCI
310 320 330 340 350 360
YCKYAVHQRC VSNSIPGCVK TYSKAKRSGE VMQHAWVEGN SSVKCDRCHK SIKCYQSVTA
370 380 390 400 410 420
RHCVWCRMTF HRKCELSTAC DGGELKDHIL LPTSIYPVTR DRQAGKSDSG AAAKGELVMQ
430 440 450 460 470 480
YKIIPSPGTH PLLVLVNPKS GGRQGERILQ KFHYLLNPKQ VFNLDKGGPT PGLNFFQDTP
490 500 510 520 530 540
DFRVLACGGD GTVGWILDCI DKANFTKHPP VAVLPLGTGN DLARCLRWGG GYEGGSLTKI
550 560 570 580 590 600
LKEIEQSPLV MLDRWYLEVM PREEVENGDQ VPYNIMNNYF SIGVDASIAH RFHVMREKHP
610 620 630 640 650 660
EKFNSRMKNK LWYFEFGTSE TFAATCKKLH DHIELECDGV EVDLSNIFLE GIAILNIPSM
670 680 690 700 710 720
YGGTNLWGET KKNRAVIRES RKSVTDPKEL KCCVQDLSDQ LLEVVGLEGA MEMGQIYTGL
730 740 750 760 770 780
KSAGRRLAQC SSVTIRTKKL LPMQVDGEPW MQPPCMIKIT HKNQAPMMMG PPQKSSFFSL
RRKSRSKD