Q6P5E8

PR
Gene name
Dgkq
Protein name
Diacylglycerol kinase theta
Names
DAG kinase theta, Diglyceride kinase theta, DGK-theta
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:110524
EC number
2.7.1.93: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6P5E8

Entry ID Method Resolution Chain Position Source
AF-Q6P5E8-F1 Predicted AlphaFoldDB

34 variants for Q6P5E8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs864275001 42 E>G No EVA
rs48061479 49 G>A No EVA
rs3388775699 175 T>R No EVA
rs3388780410 183 G>R No EVA
rs3395942775 187 S>P No EVA
rs3388780477 203 V>A No EVA
rs3388758576 235 S>F No EVA
rs3388771783 243 V>G No EVA
rs3388778156 263 V>A No EVA
rs3388749151 273 V>I No EVA
rs3388778306 293 K>I No EVA
rs3388780400 319 A>S No EVA
rs3410573636 374 S>P No EVA
rs260475868 375 V>M No EVA
rs29549416 456 E>D No EVA
rs3388758541 475 S>R No EVA
rs222828972 487 T>S No EVA
rs3388761763 495 V>M No EVA
rs3388771780 533 A>G No EVA
rs3388771780 533 A>V No EVA
rs3388778073 541 F>L No EVA
rs3388777279 704 M>V No EVA
rs47147307 719 T>P No EVA
rs3388777253 753 A>S No EVA
rs3388749153 754 R>C No EVA
rs3388780423 764 R>K No EVA
rs3388778121 784 S>T No EVA
rs3395759926 802 S>C No EVA
rs3395315484 803 I>N No EVA
rs3388780441 881 V>M No EVA
rs3395969549 890 P>* No EVA
rs3388778322 891 G>C No EVA
rs3388769733 913 R>G No EVA
rs33203948 918 N>I No EVA

No associated diseases with Q6P5E8

4 regional properties for Q6P5E8

Type Name Position InterPro Accession
repeat Leucine-rich repeat 66 - 87 IPR001611-1
repeat Leucine-rich repeat 88 - 109 IPR001611-2
repeat Leucine-rich repeat 110 - 131 IPR001611-3
repeat Leucine-rich repeat 132 - 153 IPR001611-4

Functions

Description
EC Number 2.7.1.93 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cytoplasm
  • Cytoplasm, cytosol
  • Cell membrane
  • Synapse
  • Cytoplasm, cytoskeleton
  • Nucleus
  • Nucleus speckle
  • Nucleus matrix
  • Translocates to the plasma membrane in response to steroid hormone receptor stimulation
  • Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH
  • Translocates to the nucleus in response to thrombin stimulation (By similarity)
  • Association with the nuclear matrix is regulated by nerve growth factor (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

13 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endosome A vacuole to which materials ingested by endocytosis are delivered.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
nuclear matrix The dense fibrillar network lying on the inner side of the nuclear membrane.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynapse The part of a synapse that is part of the post-synaptic cell.
presynapse The part of a synapse that is part of the presynaptic cell.
vesicle membrane The lipid bilayer surrounding any membrane-bounded vesicle in the cell.

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
diacylglycerol kinase activity Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate.
DNA-binding transcription factor binding Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.
kinase binding Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group.
metal ion binding Binding to a metal ion.
phospholipase binding Binding to a phospholipase.
transmembrane receptor protein tyrosine kinase activator activity Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase.

25 GO annotations of biological process

Name Definition
cAMP-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
diacylglycerol metabolic process The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.
G protein-coupled receptor signaling pathway The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
glycerolipid metabolic process The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
lipid phosphorylation The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.
negative regulation of gene expression Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of peptidyl-threonine phosphorylation Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
phosphatidic acid biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of peptidyl-tyrosine phosphorylation Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
protein kinase C signaling A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
protein kinase C-activating G protein-coupled receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).
regulation of cholesterol metabolic process Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
regulation of cortisol biosynthetic process Any process that modulates the frequency, rate or extent of cortisol biosynthetic process.
regulation of G protein-coupled receptor signaling pathway Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.
regulation of gluconeogenesis Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
regulation of progesterone biosynthetic process Any process that modulates the frequency, rate or extent of progesterone biosynthetic process.
regulation of synaptic vesicle endocytosis Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis.
regulation of TORC1 signaling Any process that modulates the frequency, rate or extent of TORC1 signaling.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to ATP Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.
response to cAMP Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
thrombin-activated receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by thrombin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P52429 DGKE Diacylglycerol kinase epsilon Homo sapiens (Human) PR
O88673 Dgka Diacylglycerol kinase alpha Mus musculus (Mouse) PR
Q91WG7 Dgkg Diacylglycerol kinase gamma Mus musculus (Mouse) PR
P20192 DGKA Diacylglycerol kinase alpha Sus scrofa (Pig) PR
P49620 Dgkg Diacylglycerol kinase gamma Rattus norvegicus (Rat) PR
P51556 Dgka Diacylglycerol kinase alpha Rattus norvegicus (Rat) PR
Q8VZG1 DGK3 Diacylglycerol kinase 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FFN7 DGK2 Diacylglycerol kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAAAAEPGAR TWPGSGSPRL GSPAGSPVLG ISGRTRPGSG PERTSRAIGS AAPGHSFRKV
70 80 90 100 110 120
TLTKPTFCHL CSDFIWGLAG FLCDVCNFMS HEKCLKQVKT PCTSIAPSLV RVPVAHCFGS
130 140 150 160 170 180
LGLYKRKFCV VCRKSLEVPA FRCEVCELHV HPDCVPFACS DCRQCHQDGQ QDYDTYHHHW
190 200 210 220 230 240
REGNLPSGAR CEVCRKTCGS SDVLAGVRCE WCGVQAHSVC STALAPECTF GRLRSMVLPP
250 260 270 280 290 300
SCVRLLSRNF SKMHCFRIPE TMVLELGDGD DGVDGSAAIG TGREVLTATE STKQTLKIFD
310 320 330 340 350 360
GNDSMRKNQF RLVTVSRLAR NEEVMEAALR AYYISEDPKD FQLQALPLSG NAQALGKAGT
370 380 390 400 410 420
TEEEASKGSC PRDSVPEAWV IRSLPRTQEI LKIYPGWLKV GVAYVSIRVN SQSTARSVVQ
430 440 450 460 470 480
EVLPLFGQQV EDKERFQLIE VLMSSRQVQR TVLADEEPLL DRLWDIRQTS VRQVSQTRFY
490 500 510 520 530 540
VAETRATAPR VSLFVGGLPP GLSPQDYSNL LHEAMATKAA VVSVSHVYSL QGAVILDVTC
550 560 570 580 590 600
FAEAERLYML ARDTAVHGRP LTALVLPDVL HTKLPPDCCP LLVFVNPKSG GLKGRELLCS
610 620 630 640 650 660
FRKLLNPHQV FELTNGGPLP GFHLFSQVPS FRVLVCGGDG TVGWVLAALE ETRRHLACPE
670 680 690 700 710 720
PSVAILPLGT GNDLGRVLRW GAGYSGEDPF SVLVSVDEAD AVLMDRWTIL LDAHEIDSTE
730 740 750 760 770 780
NNVVETEPPK IVQMNNYCGI GIDAELSLDF HQAREEEPGK FTSRFHNKGV YVRVGLQKIS
790 800 810 820 830 840
HSRSLHKEIR LQVEQQEVEL PSIEGLIFIN IPSWGSGADL WGSDNDSRFE KPRIDDGLLE
850 860 870 880 890 900
VVGVTGVVHM GQVQGGLRSG IRIAQGSYFR VTLLKATPVQ VDGEPWVQAP GHMIISATAP
910 920 930
KVHMLRKAKQ KPRKAGANRD TRVDTLPAPE GNPL