Q94AX4

PR
Gene name
DLD
Protein name
D-lactate dehydrogenase [cytochrome], mitochondrial
Names
AtD-LDH, D-lactate ferricytochrome C oxidoreductase, Glycolate dehydrogenase
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G06580
EC number
1.1.2.4: With a cytochrome as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

39-130 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q94AX4

Entry ID Method Resolution Chain Position Source
AF-Q94AX4-F1 Predicted AlphaFoldDB

27 variants for Q94AX4

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_5_2016470_C_A 2 A>S No 1000Genomes
tmp_5_2016442_T_A 11 K>I No 1000Genomes
ENSVATH13942624 16 F>V No 1000Genomes
tmp_5_2016367_A_G 36 L>P No 1000Genomes
tmp_5_2016340_A_G 45 L>P No 1000Genomes
tmp_5_2016313_A_G 54 F>S No 1000Genomes
tmp_5_2016232_G_C 81 A>G No 1000Genomes
tmp_5_2016112_A_C 93 D>E No 1000Genomes
tmp_5_2015480_C_A 177 G>V No 1000Genomes
tmp_5_2015442_C_T 190 G>R No 1000Genomes
ENSVATH06932031 213 I>V No 1000Genomes
ENSVATH06932029 229 E>K No 1000Genomes
ENSVATH06932029 229 E>Q No 1000Genomes
ENSVATH06931984 299 I>M No 1000Genomes
tmp_5_2014156_T_C 312 I>V No 1000Genomes
tmp_5_2013562_T_C 344 M>V No 1000Genomes
tmp_5_2013440_C_T 359 V>I No 1000Genomes
ENSVATH06931950 362 R>K No 1000Genomes
ENSVATH03030707 369 G>E No 1000Genomes
ENSVATH06931942 397 Q>L No 1000Genomes
ENSVATH06931940 403 H>Y No 1000Genomes
tmp_5_2013005_G_A 420 L>F No 1000Genomes
ENSVATH06931919 490 S>N No 1000Genomes
tmp_5_2012163_A_T 504 F>L No 1000Genomes
ENSVATH00609119 517 T>S No 1000Genomes
ENSVATH06931899 548 T>M No 1000Genomes
ENSVATH03030700 558 G>E No 1000Genomes

No associated diseases with Q94AX4

3 regional properties for Q94AX4

Type Name Position InterPro Accession
domain FAD-binding oxidoreductase/transferase, type 4, C-terminal 319 - 560 IPR004113
domain FAD linked oxidase, N-terminal 146 - 282 IPR006094
domain FAD-binding domain, PCMH-type 142 - 319 IPR016166

Functions

Description
EC Number 1.1.2.4 With a cytochrome as acceptor
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
D-lactate dehydrogenase (cytochrome) activity Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate.
D-lactate dehydrogenase activity Catalysis of the reaction: (R)-lactate + NAD(+) = H(+) + NADH + pyruvate.
FAD binding Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
glycolate dehydrogenase activity Catalysis of the reaction: A + glycolate = AH(2) + glyoxylate.
identical protein binding Binding to an identical protein or proteins.

2 GO annotations of biological process

Name Definition
lactate catabolic process The chemical reactions and pathways resulting in the breakdown of lactate.
methylglyoxal catabolic process The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32891 DLD1 D-lactate dehydrogenase [cytochrome] 1, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q5JLP4 CKX4 Cytokinin dehydrogenase 4 Oryza sativa subsp japonica (Rice) PR
Q6YW51 CKX6 Cytokinin dehydrogenase 6 Oryza sativa subsp japonica (Rice) PR
Q6YW50 CKX7 Cytokinin dehydrogenase 7 Oryza sativa subsp japonica (Rice) PR
A3AVP1 CKX8 Cytokinin dehydrogenase 8 Oryza sativa subsp japonica (Rice) PR
Q8LNV6 CKX3 Cytokinin dehydrogenase 3 Oryza sativa subsp japonica (Rice) PR
Q9LY71 CKX6 Cytokinin dehydrogenase 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FUJ2 CKX4 Cytokinin dehydrogenase 4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTS3 CKX3 Cytokinin dehydrogenase 3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAFASKFARS KTILSFLRPC RQLHSTPKST GDVTVLSPVK GRRRLPTCWS SSLFPLAIAA
70 80 90 100 110 120
SATSFAYLNL SNPSISESSS ALDSRDITVG GKDSTEAVVK GEYKQVPKEL ISQLKTILED
130 140 150 160 170 180
NLTTDYDERY FHGKPQNSFH KAVNIPDVVV FPRSEEEVSK ILKSCNEYKV PIVPYGGATS
190 200 210 220 230 240
IEGHTLAPKG GVCIDMSLMK RVKALHVEDM DVIVEPGIGW LELNEYLEEY GLFFPLDPGP
250 260 270 280 290 300
GASIGGMCAT RCSGSLAVRY GTMRDNVISL KVVLPNGDVV KTASRARKSA AGYDLTRLII
310 320 330 340 350 360
GSEGTLGVIT EITLRLQKIP QHSVVAVCNF PTVKDAADVA IATMMSGIQV SRVELLDEVQ
370 380 390 400 410 420
IRAINMANGK NLTEAPTLMF EFIGTEAYTR EQTQIVQQIA SKHNGSDFMF AEEPEAKKEL
430 440 450 460 470 480
WKIRKEALWA CYAMAPGHEA MITDVCVPLS HLAELISRSK KELDASSLLC TVIAHAGDGN
490 500 510 520 530 540
FHTCIMFDPS SEEQRREAER LNHFMVHSAL SMDGTCTGEH GVGTGKMKYL EKELGIEALQ
550 560
TMKRIKKTLD PNDIMNPGKL IPPHVCF